Coronavirus Disease 2019 outbreak: preparedness and readiness of countries in the Eastern Mediterranean Region

Al-Mandhari, Ahmed; Samhouri, Dalia; Abubakar, Abdinasir; Brennan, Richard

doi:10.26719/2020.26.2.136

Cited by 52 publications

(43 citation statements)

References 3 publications

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Section: Introductionmentioning

confidence: 99%

“…On January 30, 2020, the World Health Organization (WHO) announced that the outbreak of new coronavirus disease (coronavirus disease 2019 ) was a public health emergency of international concern (PHEIC) [1,2]. It is the 6th time the WHO has declared a PHEIC since the International Health Regulations came into effect in 2005 [2,3]. COVID-19 has spread to nearly 90 countries, with more than one hundred thousand confirmed cases, endangering the health of people all over the world and causing a global health crisis [4,5].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Active constituents and mechanisms of Respiratory Detox Shot, a traditional Chinese medicine prescription, for COVID-19 control and prevention: Network-molecular docking-LC–MSE analysis

Zhang

Hou

et al. 2020

Journal of Integrative Medicine

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Active constituents and mechanisms of Respiratory Detox Shot, a traditional Chinese medicine prescription, for COVID-19 control and prevention: Network-molecular docking-LC–MSE analysis

Zhang

Hou

et al. 2020

Journal of Integrative Medicine

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“…8 In addition to this, 2200 beds have been assigned for isolation of quarantined and suspected cases. 9 The different categories of beds are prepared due to the severity of symptoms of COVID-19.…”

Section: Introductionmentioning

confidence: 99%

<p>Clinical Characteristics and Outcomes Among COVID-19 Hospitalized Patients with Chronic Conditions: A Retrospective Single-Center Study</p>

Almalki¹,

Khan²,

Almazrou³

et al. 2020

JMDH

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Evidence to date suggests that having chronic conditions increases the probability of severe illness from severe coronavirus disease 2019 (COVID-19). Thus, it is essential to identify the features of those patients. The purpose of this research was to identify the clinical characteristics and outcomes of COVID-19 patients with chronic conditions. Patients and Methods: A retrospective cross-sectional single-center study was conducted using electronic medical records of hospitalized COVID-19 patients between March 1, 2020, and May 20, 2020. Patients' basic information, laboratory test, clinical data, medications, and outcome data have been extracted and compared among three groups: patients without chronic conditions, patients with one chronic condition, and patients with two or more chronic conditions. Chi-square, Fisher's exact test, Student's t-test, and the Mann-Whitney U-test were used. Results: The study population was 458 patients, with an average age of 38.8 years (standard deviation (SD) 12.8). There were 398 (86.9%) males in the study population, most of them with one chronic condition. There were 14 (14.3%) smokers, and the majority of them were among patients with two or more chronic conditions. Longer hospital stay and time in the intensive care unit (ICU), a higher probability of ICU admission, and the need for mechanical ventilation were identified among patients with two or more chronic conditions. Dyspnea, an increased level of platelet counts, and a reduction in hemoglobin levels were discovered among patients with two or more chronic conditions. Conclusion: Patients with more chronic conditions were at higher risk of yielding poor clinical outcomes. Prevention and treatment of infections in these patients merit more attention.

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“…Coronaviruses members belong to the subfamily Coronovirinae within the family Coronaviridae and the order Nidovirales [7]. They are zoonotic pathogens that can be transmitted to human due to direct contact with animals; many scienti c reports claimed COVID-19 originated in bats and transmitted to humans via intermediate host animals in the seafood market [8][9][10]. Coronaviruses genome is a single-stranded positive-sense RNA (+ssRNA) molecule with genomic size ranges between 27-32 kbp which contains at least six open reading frames (ORFs) [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

The first report of the most important sequential differences between COVID-19 and MERS viruses by attribute weighting models, the importance of Nucleocapsid (N) protein

Ebrahimi

Novikov

Ebrahimie

et al. 2020

Preprint

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COVID-19 and the Middle East respiratory syndrome-related coronavirus (MERS) viruses are from coronaviridae family; the former became a pandemic while the latter confined to a limited region. Their pathogenicity and infection rates are also different; the high mortality rate for MERS with low spreading capability. To investigate the possible structural changes at RNA sequences of both virus, 1621 and 125 sequences of COVID-19 and MERS downloaded and converted to polynomial datasets and seven attribute weighting (feature selection) approaches have been used for the analysis of genomic sequences of COVID-19 and MERS viruses. The end nucleotide sequences (from 29288 to the end genome positions) selected by the most attribute weighting models to be significantly different between two virus classes followed by smaller piece at 5700 and 1750 and 7600 nucleotide positions. These parts encode Nucleocapsid (N), Papin-like protease (NSP3) and NSP4 proteins of COVID-19. The finding for the first time reports the structural differences between two important viruses at the sequential level and paves the road to decipher new emerging COVID-19 virus high pathogenicity.

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Coronavirus Disease 2019 outbreak: preparedness and readiness of countries in the Eastern Mediterranean Region

Cited by 52 publications

References 3 publications

Active constituents and mechanisms of Respiratory Detox Shot, a traditional Chinese medicine prescription, for COVID-19 control and prevention: Network-molecular docking-LC–MSE analysis

Active constituents and mechanisms of Respiratory Detox Shot, a traditional Chinese medicine prescription, for COVID-19 control and prevention: Network-molecular docking-LC–MSE analysis

<p>Clinical Characteristics and Outcomes Among COVID-19 Hospitalized Patients with Chronic Conditions: A Retrospective Single-Center Study</p>

The first report of the most important sequential differences between COVID-19 and MERS viruses by attribute weighting models, the importance of Nucleocapsid (N) protein

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