Coronavirus disease-2019 (COVID-19): value of IL-6 inhibitors

Насонов, Е. Л.

doi:10.18093/0869-0189-2020-30-5-629-644

Cited by 7 publications

(1 citation statement)

References 156 publications

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“…Уральский медицинский журнал umjusmu.ru Литературный обзор У пациентов, умерших от новой коронавирусной инфекции, регистрируются повышенные уровни прокальцитонина, ИЛ-6, мочевины, креатинина, цистатина С, прямого билирубина и холинэстеразы в сыворотке крови, а также СРБ, повышение уровня которого уникально для пациентов с COVID-19. Повышенные уровни ИЛ-6, ИЛ-2R, ИЛ-8, ИЛ-10 и GM-CSF были обнаружены у госпитализированных пациентов, особенно в критическом состоянии, и связаны с дыхательной недостаточностью и плохим прогнозом [35][36][37][38][39][40][41][42][43][44][45][46][47][48][49].…”

Section: сывороточные маркерыunclassified

Prognostic Factors Associated with the Severe Course of a New Coronavirus Infection

Khamanova,

Frayfeld,

Mullagalieva

et al. 2024

Урал. мед. журнал

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Introduction. Novel coronavirus infection (COVID-19) is a respiratory infectious disease caused by the novel severe acute respiratory syndrome 2 coronavirus (SARS-CoV-2). It is characterized by a heterogeneous course of the disease from asymptomatic and mild forms to more severe and fatal outcomes. There are many risk factors for a severe course of a new coronavirus infection, in most cases, a severe course of the disease is associated with the individual characteristics of the patient, especially with dysregulation of the immune response. In this article, we reviewed the main prognostic factors for the severity of the disease.The aim of the study is to determine the unfavorable prognostic factors associated with the severe course of a new coronavirus infection caused by the SARS-CoV-2 virus in foreign and domestic literature sources.Materials and methods. To achieve this goal, scientific publications on the new coronavirus infection caused by the SARS-CoV-2 virus were analyzed in the scientometric databases PubMed, National Center for Biotechnological Information (NCBI), Cochrane, Web of Science, Scopus, MEDLINE (2019–2022), and Russian specialized journals on infectious diseases (2019–2022). Particular attention was paid to factors influencing the severe course of a new coronavirus infection.Results. Risk factors for a severe course of a new coronavirus infection include: lipid spectrum, advanced age, hemostasis system, changes in the leukocyte count, serum markers. Mathematical models of the course of a new coronavirus infection have also been developed.Discussion. In most studies, scientists note that the uncontrolled course of COVID-19 disease is associated with a dysregulated immune response. One of the main methods of influencing the immune system is vaccination.Conclusion. There are many factors that contribute to the development of severe forms of the disease of a new coronavirus infection. However, thanks to universal vaccination against a new coronavirus infection, the frequency of severe forms of the disease and deaths has significantly decreased. Novel coronavirus infection (COVID-19) is a respiratory infectious disease caused by the novel severe acute respiratory syndrome 2 coronavirus (SARS-CoV-2).

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Section: сывороточные маркерыunclassified

Prognostic Factors Associated with the Severe Course of a New Coronavirus Infection

Khamanova,

Frayfeld,

Mullagalieva

et al. 2024

Урал. мед. журнал

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Activity of Negative Regulation of the PD-1/PD-L1/PD-L2 T-Cell Response System in Patients with Pneumonia and Inﬂuenza A (H1N1)

Малярчиков

Шаповалов

Лукьянов

et al. 2021

Obŝaâ reanimatologiâ

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Systemic inﬂammation is an integral pathophysiological component of many critical illnesses. The systemic inﬂammatory response is based on a cascade of interactions leading to hypercytokinemia and, as a consequence, multiple organ failure, which is one of the main causes of mortality in intensive care units.Aim of the study. To evaluate the activity of the negative regulation system of T-cell response by determining the plasma levels of PD-1, PD-L1 and PD-L2 molecules in pneumonia patients with inﬂuenza A (H1N1).Materials and methods. 85 patients with pneumonia and underlying inﬂuenza A (H1N1) were examined. Among them there were 30 patients with severe pneumonia, and 55 patients with non-severe pneumonia. Plasma levels of PD-1, PD-L1, PD-L2 molecules was determined by ﬂow cytoﬂuorometry method.Results. In patients with severe pneumonia and underlying inﬂuenza A (H1N1), the plasma level of PD-1 receptor increased 4.6-fold, while the concentration of its ligands PD-L1 and PD-L2 increased 10.6 and 2.2-fold, respectively.Conclusion. Signiﬁcant increase in levels of PD-1 and its ligands PD-L1 and PD-L2 in patients with pneumonia and underlying inﬂuenza A (H1N1) indicates the involvement of negative regulation system of T-cell response in the cascade of immunological reactions and is associated with the severe disease. Possible correction of immune reactions realized through PD-1/PD-L1/PD-L2 complex in critically ill patients is a promising research avenue.

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Peculiarities of the course of COVID-19 in patients with chronic noncommunicable diseases (literature review)

Sharipova

Ivkina

Архангельская

et al. 2022

Russian Journal of Physiotherapy, Balneology and Rehabilitation

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An electronic search for publications on the features of the course of COVID-19 in patients with the most common chronic noncommunicable diseases (arterial hypertension, diabetes mellitus and obesity) was carried out using the Scopus, Web of Science, MedLine, The Cochrane Library, EMBASE, Global Health, CyberLeninka databases, RSCI, as well as journals peer-reviewed by the Higher Attestation Commission. The review analyzed the effect of comorbidity on the prognosis of a new coronavirus infection (complication rate, severity of the course, mortality). It has been shown that previous noncommunicable diseases are a significant risk factor for adverse outcomes in patients with COVID-19, and if the effect of arterial hypertension is not confirmed by all authors, then type 2 diabetes mellitus, as well as any degree of obesity, are important prognostic signs of an unfavorable course of the new coronavirus infections. Thus, in the context of the COVID-19 pandemic, patients suffering from chronic noncommunicable diseases need more careful monitoring and preventive measures aimed not only at preventing infection with the new coronavirus, but also at slowing the progression of these pathologies and their complications.

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Coronavirus disease-2019 (COVID-19): value of IL-6 inhibitors

Cited by 7 publications

References 156 publications

Prognostic Factors Associated with the Severe Course of a New Coronavirus Infection

Prognostic Factors Associated with the Severe Course of a New Coronavirus Infection

Activity of Negative Regulation of the PD-1/PD-L1/PD-L2 T-Cell Response System in Patients with Pneumonia and Inﬂuenza A (H1N1)

Peculiarities of the course of COVID-19 in patients with chronic noncommunicable diseases (literature review)

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