Coronavirus disease 2019 (COVID-19): latest developments in potential treatments

Hon, Kam Lun; Leung, Karen Ka Yan; Leung, Alexander K. C; Qian, Suyun; Chan, Vivian Py; Ip, Patrick; Wong, Ian C K

doi:10.7573/dic.2020-4-15

Cited by 19 publications

(17 citation statements)

References 75 publications

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“… 1 , 4 – 7 Recently, HCQ has also been used in the treatment of coronavirus disease-19 (COVID-19). 8 – 10 HCQ has also been suggested as a candidate prophylactic agent for COVID-19 in populations at high risk for COVID-19, such as high-risk groups in New York and Italy. 11 HCQ is preferred to chloroquine because it is less toxic.…”

Section: Discussionmentioning

confidence: 99%

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Hydroxychloroquine-induced hyperpigmentation in a 14-year-old female with systemic lupus erythematosus

Leung

McMillan

Human

et al. 2020

DIC

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Hydroxychloroquine (HCQ)-induced hyperpigmentation is uncommon but is increasingly recognized. To our knowledge, HCQ-induced hyperpigmentation has not been reported in the pediatric age group. Herein, we present the case of a 14-year-old girl with systemic lupus erythematosus, who developed hyperpigmentation on her shins and dorsum of the left foot, approximately 3 years after initiating treatment with HCQ. Physicians who treat children with HCQ for reasons such as rheumatologic disorders, dermatologic disorders and, more recently, coronavirus disease-19 should be aware of this less-known side effect of HCQ.

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Section: Discussionmentioning

confidence: 99%

“…For the treatment of COVID-19, HCQ works by blocking severe acute respiratory syndrome-related coronavirus (the causative virus for COVID-19) viral entry into host cells through inhibition of angiotensin-converting enzyme 2 receptor glycosylation, reducing viral replication, and blocking the export of newly constructed virions. 8 – 10 …”

Section: Discussionmentioning

confidence: 99%

Hydroxychloroquine-induced hyperpigmentation in a 14-year-old female with systemic lupus erythematosus

Leung

McMillan

Human

et al. 2020

DIC

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“…Ribavirin also has broad antiviral activity associated with its ability to inhibit inosine monophosphate dehydrogenase and thereby constrain guanosine production (Khalili et al, 2020). Ribavirin is active against many RNA viruses such as vaccinia virus, herpesvirus, vesicular stomatitis virus, hepatitis C virus, respiratory syncytial virus, SARS-CoV and MERS-CoV (Jordan et al, 2018;Hon et al, 2020). However, treatment solely with ribavirin is of limited efficacy in patients with SARS-CoV and MERS-CoV (Falzarano et al, 2013).…”

Section: Ribavirinmentioning

confidence: 99%

COVID-19: the epidemiology and treatment

Ren

2020

Br J Hosp Med

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After initially emerging in late 2019, coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread rapidly to cause a global pandemic. SARS-CoV-2 is a betacoronavirus that is closely related to severe acute respiratory syndrome coronavirus and Middle East respiratory syndrome coronavirus, all of which can cause severe lung injury, respiratory distress and cytokine storm. While mortality rates associated with SARS-CoV-2 are lower than those associated with severe acute respiratory syndrome coronavirus or Middle East respiratory syndrome coronavirus, it is more contagious and spreads more rapidly than these other viruses. This article summarises the epidemiology and potential options for treating COVID-19 to give a foundation for future studies of the diagnosis, treatment and prevention of this deadly disease.

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“…The COVID-19 pandemic has caused escalating morbidity and mortality in all nations and cities ( Hon and Leung, 2020 ; Hon et al, 2020a ). The pandemic is now nearly one year since it was initially reported in December 2019.…”

Section: Introductionmentioning

confidence: 99%

COVID-19 in Hong Kong – Public health, food safety, and animal vectors perspectives

Hon¹,

Leung²,

Tang

et al. 2021

Journal of Virological Methods

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The coronavirus disease 2019 (COVID-19) pandemic, caused by infection with a novel coronavirus (severe acute respiratory syndrome coronavirus 2, SARS-CoV-2), has led to escalating morbidity and mortality in all nations and cities. SARS-CoV-2 lies within the same coronavirus family as SARS-CoV (2003) and MERS-CoV (2012), though there are genetic and epidemiological differences between the viruses, as well as different clinical presentations in the patients. Despite this, Hong Kong has so far managed to control the pandemic very successfully. Here we offer a Hong Kong perspective on different aspects of the pandemic virus (SARS-CoV-2) and the disease : public health (diagnosis and control), food safety (reducing transmission in the workplace) and animal vectors (controlling potential reservoirs of the virus and their movements).

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Coronavirus disease 2019 (COVID-19): latest developments in potential treatments

Cited by 19 publications

References 75 publications

Hydroxychloroquine-induced hyperpigmentation in a 14-year-old female with systemic lupus erythematosus

Hydroxychloroquine-induced hyperpigmentation in a 14-year-old female with systemic lupus erythematosus

COVID-19: the epidemiology and treatment

COVID-19 in Hong Kong – Public health, food safety, and animal vectors perspectives

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