Abstract:COVID-19 has spread worldwide, with more than 2.5 million cases and over 80,000 deaths reported by the end of April 2020. In addition to pulmonary symptoms, gastrointestinal symptoms have been increasingly recognized as part of the disease spectrum. COVID-19-associated coagulopathy has recently emerged as a major component of the disease, leading to high morbidity and mortality. Ischemic colitis has been reported to be associated with a hypercoagulable state. To our knowledge, there have not been any case repo… Show more
“…Some studies used abdominal diagnostic imaging in patients with SARS-CoV-2 infection to assess their intestinal condition and provide evidence for GI involvement. The most frequently reported observations are intestinal ischemia, including vessel thrombosis/embolism in the small bowel and/or colon and ischemic colitis [ 45 , 46 , 47 , 48 , 49 , 50 , 51 ]. Bhayana et al examined 42 abdominal CT scans of 412 hospitalized patients with COVID-19 [ 48 ].…”
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the global coronavirus disease 2019 (COVID-19) outbreak. Along with the respiratory tract, the gastrointestinal (GI) tract is one of the main extra-pulmonary targets of SARS-CoV-2 with respect to symptom occurrence and is a potential route for virus transmission, most likely due to the presence of angiotensin-converting enzyme 2. Therefore, understanding the mechanisms of GI injury is crucial for a harmonized therapeutic strategy against COVID-19. This review summarizes the current evidence for the clinical features of and possible pathogenic mechanisms leading to GI injury in COVID-19.
“…Some studies used abdominal diagnostic imaging in patients with SARS-CoV-2 infection to assess their intestinal condition and provide evidence for GI involvement. The most frequently reported observations are intestinal ischemia, including vessel thrombosis/embolism in the small bowel and/or colon and ischemic colitis [ 45 , 46 , 47 , 48 , 49 , 50 , 51 ]. Bhayana et al examined 42 abdominal CT scans of 412 hospitalized patients with COVID-19 [ 48 ].…”
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the global coronavirus disease 2019 (COVID-19) outbreak. Along with the respiratory tract, the gastrointestinal (GI) tract is one of the main extra-pulmonary targets of SARS-CoV-2 with respect to symptom occurrence and is a potential route for virus transmission, most likely due to the presence of angiotensin-converting enzyme 2. Therefore, understanding the mechanisms of GI injury is crucial for a harmonized therapeutic strategy against COVID-19. This review summarizes the current evidence for the clinical features of and possible pathogenic mechanisms leading to GI injury in COVID-19.
“…Deep vein thrombosis and pulmonary thromboembolism are one of the most severe consequences of this vascular disease. On the other hand, hemorrhagic colitis, an under-recognized COVID-19 complication, may occur due to microangiopathy of the intestinal vasculature [ 10 ]. Fig.…”
the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has led to over 33 million infections and 1.000.000 deaths worldwide [1]. Compared to other coronavirus outbreaks (SARS-CoV-1, MERS-CoV), SARS-CoV-2 is characterized by a higher basic reproductive rate and an overall lower mortality [2]. However, while coronavirus disease 2019 (COVID-19) typically begins as an infection of the upper aerodigestive tract, it may progress to severe forms, with an acute respiratory distress syndrome (ARDS) and a multisystemic disease.COVID-19 ARDS shares the common histological hallmarks with other infectious/non-infectious ARDS. Unspecific diffuse alveolar damage (DAD), as its histologic correlate, is characterized by edema, hemorrhage and intra-alveolar fibrin deposition, but in case of COVID-19 ARDS, also by a distinct angiocentric lymphocytic inflammation [3][4][5]. DAD is the leading pattern of lung injury and has been shown to be independent of mechanical ventilation. There is some evidence for alternative injury patterns in COVID-19 ARDS, such as acute fibrinous organizing pneumonia (AFOP). Nonetheless, COVID-19-induced DAD is by far the most frequently reported one and is also characterized by more distinct morphologic features, including vascular changes [5].In that, the detection of SARS-CoV-2 in multiple organs (respiratory tract, heart, endothelium, digestive tract, kidneys, brain) and multisystemic clinical features, suggest that COVID-19 might be a systemic "vascular disease" (Fig.
“…It was suggested that the hypercoagulability observed in COVID19 was related to the high inflammatory state associated with a “cytokine storm” rather than a progression of disseminated intravascular coagulation (DIC) [ 3 ]. To our knowledge, few cases of SARS-CoV-2- induced ischemic colitis have been reported [ 1 ] and none of them with a massive short bowel resection with short bowel disease as final result.…”
Section: Discussionmentioning
confidence: 99%
“…Ischemic colitis has been reported to be associated with a hypercoagulable state, However few cases have been reported of COVID-19 associated with ischemic colitis [ 1 ].…”
COVID-19 has spread worldwide, with more than 2.5 million cases and over 80,000 deaths reported by the end of April 2020. In addition to pulmonary symptoms, gastrointestinal symptoms have been increasingly recognized as part of the disease spectrum. COVID-19-associated coagulopathy has recently emerged as a major component of the disease, leading to high morbidity and mortality.
Ischemic colitis has been reported to be associated with a hypercoagulable state, However few cases have been reported of COVID-19 associated with ischemic colitis.
We would like to report a case of a 53 year old man with medical history of type 2 diabetes, and hypercholesterolemia, with ishchemic colitis as first manifestation of infection of COVID 19.
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