Coronavirus Disease-19: An Interim Evidence Synthesis of the World Association for Infectious Diseases and Immunological Disorders (Waidid)

Abstract

Coronavirus disease 2019 (COVID-19) is a rapidly evolving, highly transmissible, and potentially lethal pandemic caused by a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). As of June 11 2020, more than 7,000,000 COVID-19 cases have been reported worldwide, and more than 400,000 patients have died, affecting at least 188 countries. While literature on the disease is rapidly accumulating, an integrated, multinational perspective on clinical manifestations, Abu-Raya et al.Coronavirus Disease-19: An Interim Evidence Synthesis immunological effects, diagnosis, prevention, and treatment of COVID-19 can be of global benefit. We aimed to synthesize the most relevant literature and experiences in different parts of the world through our global consortium of experts to provide a consensus-based document at this early stage of the pandemic.

Tuberculosis and COVID-19, the new cursed duet: what differs between Brazil and Europe?

“…As medidas de distanciamento físico usam conceitos do controle da infecção tuberculosa, adaptando-os ao contexto da pandemia e à alta transmissibilidade do SARS-CoV-2. (14) Outra importante área de discussão atualmente diz respeito ao papel das vacinas. No que tange à tuberculose, ainda contamos com uma vacina antiga com efetividade apenas relativa/parcial (a vacina BCG), enquanto novas vacinas desenvolvidas rapidamente contra o SARS-CoV-2 já estão sendo usadas hoje.…”

“…Evidências preliminares sugerem que há uma necessidade específica de oferta de oxigênio e ventilação invasiva ou não invasiva em pacientes com tuberculose e COVID-19, (6,14) o que complica ainda mais o manejo desses pacientes. As sucessivas ondas de COVID-19 têm sobrecarregado de forma distinta as UTIs dos países afetados, e os quadros tradicionalmente envolvidos no manejo clínico da tuberculose (pneumologistas e especialistas em doenças infecciosas) parecem desempenhar um papel central na resposta de primeira linha à pandemia de COVID-19.…”

“…Os padrões epidemiológicos descritos nos diversos países resultam de características específicas da pandemia, da resposta dos serviços de saúde e das medidas preventivas adotadas. (40) A Figura 3 resume as informações disponíveis, por Região da OMS.…”

“…Physical distancing measures use concepts from tuberculosis infection control, adapting them to the context of the pandemic and the high transmissibility of SARS-CoV-2. 14 …”

“…Preliminary evidence suggests that there is a specific need for oxygen supply and invasive or noninvasive ventilation in patients with tuberculosis and COVID-19, 6 , 14 which further complicates the management of such patients. The subsequent waves of COVID-19 have differently burdened the ICUs in the affected countries, and the cadres traditionally involved in the clinical management of tuberculosis (pulmonologists and specialists in infectious diseases) seem to play a central role in the first-line response to the COVID-19 pandemic.…”