Coronavirus, as a source of pandemic pathogens

Abstract

The coronavirus and the influenza virus have similarities and differences. In order to comprehensively compare them, their genome sequencing data were examined by principal component analysis. Variations in coronavirus were smaller than those in a subclass of the influenza virus. In addition, differences among coronaviruses in a variety of hosts were small. These characteristics may have facilitated the infection of different hosts. Although many of the 10 coronaviruses were more conservative, those repeatedly found among humans showed annual changes. If SARS-CoV-2 changes its genome like the Influenza H type, it will repeatedly spread every few years. In addition, the coronavirus family has many other candidates for subsequent pandemics. One Sentence Summary:The genome data of coronavirus were compared to influenza virus, to 15 investigate its spreading mechanism and future status. Short titles: Coronavirus, as a source of pandemics.Main Text: COVID-19 (1, 2) is rapidly spreading worldwide. To investigate its spreading mechanism, genomes of the coronavirus were compared to those of the influenza virus (3) by principal component analysis (PCA) (4). These two RNA viruses differed in host specificity and 20 speed of mutations. Here, I present the characteristics of both and the changes in coronavirus. The coronaviruses presented smaller variations and did not differ much from host to host. These characteristics may have eased the novel transfection of coronaviruses to humans; many of the bat strains seem to have the ability to infect humans, and the intermediate animals may not be necessarily required, against the present expectations. Although many of the coronaviruses were 25