Coronavirus and Obesity: Could Insulin Resistance Mediate the Severity of Covid-19 Infection?

Finucane, Francis; Davenport, Colin

doi:10.3389/fpubh.2020.00184

Cited by 69 publications

(78 citation statements)

References 54 publications

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“…3 There has also been recent interest in the role of chronic conditions like obesity and diabetes in predicting poorer outcomes in COVID-19. 4 With this in mind, optimising nutritional status through adequate provision of energy, protein and promoting good metabolic health should remain a priority, bearing in mind that individual requirements will of course be varied.…”

Section: Introductionmentioning

confidence: 99%

Dietary micronutrients in the wake of COVID-19: an appraisal of evidence with a focus on high-risk groups and preventative healthcare

McAuliffe¹,

Ray

Fallon³

et al. 2020

BMJNPH

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Existing micronutrient deficiencies, even if only a single micronutrient, can impair immune function and increase susceptibility to infectious disease. Certain population groups are more likely to have micronutrient deficiencies, while certain disease pathologies and treatment practices also exacerbate risk, meaning these groups tend to suffer increased morbidity and mortality from infectious diseases. Optimisation of overall nutritional status, including micronutrients, can be effective in reducing incidence of infectious disease. Micronutrient deficiencies are rarely recognised but are prevalent in the UK, as well as much more widely, particularly in high-risk groups susceptible to COVID-19. Practitioners should be aware of this fact and should make it a consideration for the screening process in COVID-19, or when screening may be difficult or impractical, to ensure blanket treatment as per the best practice guidelines. Correction of established micronutrient deficiencies, or in some cases assumed suboptimal status, has the potential to help support immune function and mitigate risk of infection. The effects of and immune response to COVID-19 share common characteristics with more well-characterised severe acute respiratory infections. Correction of micronutrient deficiencies has proven effective in several infectious diseases and has been shown to promote favourable clinical outcomes. Micronutrients appear to play key roles in mediating the inflammatory response and such effects may be enhanced through correction of deficiencies. Many of those at highest risk during the COVID-19 pandemic are also populations at highest risk of micronutrient deficiencies and poorer overall nutrition. Correction of micronutrient deficiencies in established COVID-19 infection may contribute to supporting immune response to infection in those at highest risk. There is a need for further research to establish optimal public health practice and clinical intervention regimens.

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Section: Introductionmentioning

confidence: 99%

Dietary micronutrients in the wake of COVID-19: an appraisal of evidence with a focus on high-risk groups and preventative healthcare

McAuliffe¹,

Ray

Fallon³

et al. 2020

BMJNPH

View full text Add to dashboard Cite

show abstract

“…COVID-19 is more severe in elderly adults and/or patients with comorbidities, such as diabetes, obesity or hypertension, suggesting a role for insulin resistance. 18 Although differences exist between countries, the same risk factors for severity were found globally, suggesting common mechanisms. A strong relationship between hyperglycemia, impaired insulin pathway, and cardiovascular disease in type 2 diabetes is linked to oxidative stress and inflammation.…”

Section: Insulin Resistance and Covid-19mentioning

confidence: 99%

Sulforaphane: from death rate heterogeneity in countries to candidate for prevention of severe COVID-19

Bousquet

Antó

Czarlewski³

et al. 2020

Preprint

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“…Insulin Resistance (IR) might be a potential key factor behind the COVID-19 severity found in people with obesity. An article published on Frontiers Public Health supported the evidence of possible mechanisms linking IR and COVID-19 severity via the upregulation of ACE 2, the protein involved in virus entry (1). This research area is worthy of being investigated further for its implication in the prevention and treatment of this dramatic pandemic.…”

Section: Introductionmentioning

confidence: 95%

“…Recent reports of hospitalized COVID-19 patients have found obesity to be a risk factor for the worst adverse outcomes (severity and mortality). The Intensive Care National Audit and Research Centre (ICNARC) report on 2,621 patients in intensive care units in England showed that the case fatality rate was higher in obese patients 1 . The International Severe Acute Respiratory & Emerging Infection Consortium (ISARIC) International report of 1,123 patients with suspected or confirmed COVID-19 found that obesity was the fifth most observed comorbidity in hospitalized patientsonly somewhat less common than "high-risk" pulmonary conditions 2 .…”

Section: Preliminary Report On Metabolic Disorders and Covid-19mentioning

confidence: 99%

Commentary: Coronavirus and Obesity: Could Insulin Resistance Mediate the Severity of Covid-19 Infection?

Frisardi

2020

Front. Public Health

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Coronavirus and Obesity: Could Insulin Resistance Mediate the Severity of Covid-19 Infection?

Cited by 69 publications

References 54 publications

Dietary micronutrients in the wake of COVID-19: an appraisal of evidence with a focus on high-risk groups and preventative healthcare

Dietary micronutrients in the wake of COVID-19: an appraisal of evidence with a focus on high-risk groups and preventative healthcare

Sulforaphane: from death rate heterogeneity in countries to candidate for prevention of severe COVID-19

Commentary: Coronavirus and Obesity: Could Insulin Resistance Mediate the Severity of Covid-19 Infection?

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