Coronary Vasomotor Responses to Bradykinin and Acetylcholine in Patients With Coronary Spastic Angina.

Evaluation by High-Resolution Ultrasonography of Endothelial Function in Brachial Artery After Kawasaki Disease and the Effects of Intravenous Administration of Vitamin C.

“…20 Endothelial dysfunction in large arteries is an important early event in the atherogenic process and abnormal endothelial function was recently, demonstrated in patients with coronary spastic angina. 21 Using the same method as Dhillon et al, 8 we demonstrated that there is endothelial dysfunction in the brachial artery after KD. Furthermore, we also showed that there was no significant difference in the percent change in diameter of the brachial artery induced by reactive hyperemia between the patients who received gamma globulin and those who did not, indicating that late abnormalities of brachial endothelial function are not influenced by early gamma globulin therapy.…”

Cholinergic Responses of Ophthalmic Arteries in M3and M5Muscarinic Acetylcholine Receptor Knockout Mice

“…44;45 However, in some pathologies, vasodilation to acetylcholine is selectively impaired, whereas responses to other endothelium-dependent vasodilators are barely affected. 46;47 Thus, specific changes in muscarinic acetylcholine receptor function, for example, by receptor downregulation or uncoupling from intracellular signaling pathways may also contribute to abnormal cholinergic vasodilation in pathologic conditions.…”