Coronary vasomotor response to acetylcholine relates to risk factors for coronary artery disease.

Vita, Joseph A.; Treasure, Charles B.; Nabel, Elizabeth G.; McLenachan, James M.; Fish, R. David; Yeung, Alan C.; Vekshtein, V I; Selwyn, Andrew P.; Ganz, Patricia A.

doi:10.1161/01.cir.81.2.491

Cited by 1,074 publications

(509 citation statements)

References 32 publications

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“…The key general vascular modifications occurring during aging (Celermajer et al, 1994; Vita et al, 1990) are endothelial dysfunction and central arterial stiffness. Endothelial dysfunction may be due to diminished bioavailability of nitric oxide (Taddei et al, 2001; Tschudi et al, 1996).…”

Section: Systems Level Events In Aging and Admentioning

confidence: 99%

Aging and Alzheimer’s disease: Comparison and associations from molecular to system level

et al. 2018

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Alzheimer's disease is the most prevalent cause of dementia, which is defined by the combined presence of amyloid and tau, but researchers are gradually moving away from the simple assumption of linear causality proposed by the original amyloid hypothesis. Aging is the main risk factor for Alzheimer's disease that cannot be explained by amyloid hypothesis. To evaluate how aging and Alzheimer's disease are intrinsically interwoven with each other, we review and summarize evidence from molecular, cellular, and system level. In particular, we focus on study designs, treatments, or interventions in Alzheimer's disease that could also be insightful in aging and vice versa.

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Section: Systems Level Events In Aging and Admentioning

confidence: 99%

Aging and Alzheimer’s disease: Comparison and associations from molecular to system level

et al. 2018

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“…1 In addition, NO inhibits platelet adhesion and aggregation and leukocyte adhesion, and suppresses smooth muscle cell proliferation. [2][3][4] Impaired NO bioavailability may contribute to the development of endothelial dysfunction, which is considered to be important in the initiation and progression of atherosclerosis and has been related to various risk factors of coronary artery disease (CAD), such as hypercholesterolemia, 5 essential hypertension, 6 diabetes, aging, 7 as well as active and passive smoking. 8 Nitric oxide also contributes importantly to resting vascular tone and acetylcholine-induced vasodilation in normal and atheromatous coronary arteries.…”

Section: Introductionmentioning

confidence: 99%

Asymmetrical dimethylarginine: A novel risk factor for coronary artery disease

Ding

Charng

et al. 2003

Clinical Cardiology

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SummaryBackground: Asymmetrical dimethylarginine (ADMA) is an endogenous competitive inhibitor of nitric oxide synthase and has been associated with systemic atherosclerosis; however, the role of ADMA in patients with coronary artery disease (CAD) has not been investigated.Hypothesis: The present study was designed to determine whether the plasma ADMA level predicts the presence of CAD independently, and whether the plasma ADMA level correlates with the extent and severity of coronary atherosclerosis.Methods: In all, 97 consecutive patients with angina and positive exercise stress test were enrolled prospectively for coronary angiography. According to the result of angiography, the subjects were divided into two groups: Group 1 (n = 46): patients with normal coronary artery or mild CAD (< 50% stenosis of major coronary arteries); Group 2 (n = 51): patients with significant CAD (≥ 50% stenosis of major coronary arteries). Plasma levels of ADMA and L-arginine were determined by high-performance liquid chromatography. In addition, we used coronary atherosclerotic score to assess the extent and severity of CAD.Results: The plasma levels of ADMA in Group 2 patients were significantly higher than those in Group 1 patients (0.66

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“…Coronary vasodilatory function has been found to be reduced in obese subjects measured using intracoronary acetylcholine 13 and systemic adenosine infusion. 14 As reduced coronary vasoreactivity seems to be one of the earliest abnormalities in the development of coronary artery disease, 42 the increased coronary vascular resistance in obese subjects of the present study might indicate that these subjects are at increased risk of future cardiovascular events.…”

Section: Discussionmentioning

confidence: 62%

Short-term changes in inflammatory response protein (hsCRP) do not parallel with changes in coronary vasoreactivity in obese men

et al. 2005

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Aim: Obese subjects are characterized by increased high-sensitivity C-reactive protein (hsCRP) and coronary vascular resistance. Clucocorticoids suppress inflammation, a possible cardioprotective effect. We tested the short-term anti-inflammatory effect of dexamethasone (dx) on these parameters in obese subjects. Methods: Coronary vascular resistance was quantitated basally and during adenosine infusion with or without simultaneous euglycemic hyperinsulinemic clamp (insulin infusion rate of 1 mU/kg/min) in 11 obese and 19 age-matched nonobese males using positron emission tomography and 15 O-water. Each subject was studied both with and without previous dx treatment for 2 days (2 mg/day). Results: Before dx treatment, hsCRP concentration was significantly higher in obese than in nonobese subjects (1.5571.73 vs 0.3270.32 mg/l, P ¼ 0.005). In addition, coronary vascular resistances were higher (Po0.05) in obese than in nonobese subjects at baseline (139736 vs 117722) and during adenosine infusion without (3277 vs 2677) or with simultaneous clamp (2678 vs 2175 mmHg min g/ ml). Dx treatment decreased significantly hsCRP concentration in obese but not in nonobese subjects, leading to similar hsCRP concentrations between the groups (0.4570.43 vs 0.2670.42 mg/l, respectively, P ¼ 0.3). Dx had no effect on coronary vascular resistances (NS). Conclusions: Obese subjects are characterized by high hsCRP, which can be normalized by dx. However, despite this, coronary vascular resistances did not decrease in obese subjects. Short-term changes in inflammatory response protein appear not to parallel with changes in coronary vasoreactivity in obese men.

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Coronary vasomotor response to acetylcholine relates to risk factors for coronary artery disease.

Cited by 1,074 publications

References 32 publications

Aging and Alzheimer’s disease: Comparison and associations from molecular to system level

Aging and Alzheimer’s disease: Comparison and associations from molecular to system level

Asymmetrical dimethylarginine: A novel risk factor for coronary artery disease

Short-term changes in inflammatory response protein (hsCRP) do not parallel with changes in coronary vasoreactivity in obese men

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