Coronary tortuosity affects left ventricular myocardial functions: a 3D-speckle tracking echocardiography study

Doğduş, Mustafa; Demir, Emre; Çınar, Cahide Soydaş; Gürgün, Cemil

doi:10.1007/s10554-019-01760-0

Cited by 12 publications

(17 citation statements)

References 17 publications

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“…For example, 3D-STE analysis shows that the overall longitudinal strain of the left ventricle in patients with euthyroid Hashimoto's thyroiditis (eHsT) is significantly depressed than that in the control group, so it is clear that eHsT has a negative effect on left ventricular myocardial systolic function [ 14 ]. Related studies also evaluated the three-dimensional strain parameters of left ventricular myocardium in patients with coronary artery disease (CAD) and found that CAD had a considerable adverse effect on the longitudinal strain of left ventricular myocardium [ 15 ]. In patients with aortic valve sclerosis (AVS), left ventricular global longitudinal strain (LV-GLS) and left ventricular global circumferential strain (LV-GCS) were significantly decreased [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

Early Diagnosis of Abnormal Left Ventricular Systolic Functions of Rare Pathogenic Titin Mutation Gene Carriers in FHCM by Three-Dimensional Speckle Tracking Echocardiography Combined with Gene Detection

Luo

Zhu

Chen

et al. 2022

International Journal of Clinical Practice

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Objective. This study aimed to explore the early diagnosis of abnormal left ventricular systolic function of rare pathogenic titin (TTN) mutation gene carriers in familial hypertrophic cardiomyopathy (FHCM) by three-dimensional speckle tracking echocardiography (3D-STE) combined with gene detection. Methods. Eighteen members of a Hui nationality family in Ningxia province of China were enrolled in this study in July 2019. The proband was tested with high-throughput sequencing of gene detection technology to detect the whole exome, and the mutation locus of pathogenic TTN gene was analyzed. According to the result, 16 subjects were divided into two groups: carrier group (n = 4) and noncarrier group (n = 12). Related indicators from 2DE were obtained, and myocardial strain indicators from 3D-STE were analyzed by postprocessing software of Tomtec. Strain indicators included global longitudinal strain (GLS), global circumference strain (GCS), global radial strain (GRS), regional longitudinal strain (RLS), regional circumference strain (RCS), and regional radial strain (RRS). All those indicators were compared between the two groups, and a receiver operating characteristic (ROC) curve was used for further analysis. Results. There were 4 subjects diagnosed as asymptomatic TTN gene carriers with the mutation locus of Val135643Ile. Compared with the noncarrier group, GLS and partial RLS were significantly reduced in the carrier group. The ROC curve shows that GLS has the largest AUC, and its sensitivity was better than LVPWD and specificity was better than IVSD and LVMI obtained from 2DE in the carrier group. Conclusions. There were 4 subjects diagnosed as asymptomatic TTN gene carriers with the mutation locus of Val135643Ile, and their GLS and partial RLS were significantly reduced; GLS had the better sensitivity and specificity than LVPWD, IVSD, and LVMI.

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Section: Discussionmentioning

confidence: 99%

Early Diagnosis of Abnormal Left Ventricular Systolic Functions of Rare Pathogenic Titin Mutation Gene Carriers in FHCM by Three-Dimensional Speckle Tracking Echocardiography Combined with Gene Detection

Luo

Zhu

Chen

et al. 2022

International Journal of Clinical Practice

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“…Layer‐specific strain analysis was recently introduced, and endocardial strain was considered more affected in CAD, although the results were inconsistent 3,15–17 . Three‐dimensional speckle tracking echocardiography might be more useful for assessing CAD than 2DSTE 18–20 . Furthermore, a relatively large study showed that evaluation of regional longitudinal strain (RLS) could identify the culprit coronary artery in patients with stable angina pectoris 21 .…”

Section: Discussionmentioning

confidence: 99%

“…3,[15][16][17] Three-dimensional speckle tracking echocardiography might be more useful for assessing CAD than 2DSTE. [18][19][20] Furthermore, a relatively large study showed that evaluation of regional longitudinal strain (RLS) could identify the culprit coronary artery in patients with stable angina pectoris. 21 The ASE and EACVI guidelines 22 do not recommend the assessment of RLS in clinical practice because of the lack of reference values, suboptimal reproducibility, and considerable inter-vendor measurement variability.…”

Section: F I G U R Ementioning

confidence: 99%

Association of resting left ventricular global longitudinal strain with myocardial perfusion abnormalities evaluated by ¹³N‐ammonia positron emission tomography in patients with stable angina pectoris and normal left ventricular ejection fraction

et al. 2022

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Aims Little is known about whether resting left ventricular global longitudinal strain (GLS) impairment is associated with myocardial perfusion abnormalities evaluated using 13N‐ammonia positron emission tomography (13N‐NH3‐PET)‐myocardial perfusion imaging (MPI). This study aimed to investigate the correlation between resting GLS and myocardial perfusion parameters in patients with a normal left ventricular ejection fraction (LVEF). We evaluated whether resting GLS can predict myocardial perfusion abnormalities in these patients. Methods and Results We selected 157 patients with suspected stable angina pectoris who underwent both ATP‐stress NH3‐PET‐MPI and 2‐dimentional speckle tracing echocardiography. All subjects had a preserved LVEF and no known history of myocardial infarction. Patients were stratified into Group N (normal perfusion; summed stress score [SSS], 0–3; n = 101), Group M (mildly to moderately abnormal perfusion; SSS, 4–11; n = 41), or Group S (severely abnormal perfusion; SSS, 12+; n = 15). GLS was more impaired as myocardial perfusion abnormality severity increased (–17.9 ± 2.9% for Group N, –16.8 ± 3.1% for Group M, and –14.2 ± 3.5% for Group S; p < .001). GLS was weakly but significantly correlated with SSS (R = .32, p < .001), summed difference score (R = .32, p < .001), and myocardial blood flow during stress (R = –0.27, p < .001). Multivariate logistic regression analysis showed that male sex, diabetes mellitus, systolic blood pressure, and GLS were independent predictors of myocardial perfusion abnormality defined as Groups M and S. Additionally, the area under the curve for GLS for detecting myocardial perfusion abnormality was .65, and the optimal cutoff value for GLS was –16.5%, with sensitivity and specificity of 59% and 66%, respectively. Conclusion In patients with suspected angina pectoris, resting GLS impairment despite a normal LVEF might aid the detection of hemodynamically significant coronary artery disease.

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“…Myocardial strain assessed by speckle tracking echocardiography is a sensitive marker of cardiac dysfunction, with long‐term prognostic value in many cardiac conditions 10,11 especially in atherosclerotic/non‐atherosclerotic coronary artery diseases 12–14 . Previous studies demonstrated a reduced left ventricular global longitudinal strain (LV‐GLS) in patients with CMR‐proven viral myocarditis and normal left ventricular ejection fraction (LVEF) 15 .…”

Section: Introductionmentioning

confidence: 99%

“…9 Myocardial strain assessed by speckle tracking echocardiography is a sensitive marker of cardiac dysfunction, with long-term prognostic value in many cardiac conditions 10,11 especially in atherosclerotic/nonatherosclerotic coronary artery diseases. [12][13][14] Previous studies demonstrated a reduced left ventricular global longitudinal strain (LV-GLS) in patients with CMR-proven viral myocarditis and normal left ventricular ejection fraction (LVEF). 15 COVID-19 may alter both LV-GLS and right ventricular longitudinal strain (RV-LS), and these parameters were found to be independent predictors of mortality in hospitalized patients with severe disease.…”

Section: Introductionmentioning

confidence: 99%

The usefulness of speckle tracking echocardiography in identifying subclinical myocardial dysfunction in young adults recovered from mild COVID‐19

et al. 2022

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Background: Myocardial strain assessed with speckle tracking echocardiography is a sensitive marker of cardiac dysfunction. Both left-ventricular global longitudinal strain (LV-GLS) and right ventricular longitudinal strain (RV-LS) were affected by severe SARS-CoV-2 infection. However, data about cardiac involvement in patients with asymptomatic/mild Coronavirus disease-19 (COVID-19) is still lacking.Aim: To evaluate myocardial function using LV-GLS and RV-LS in patients with previous asymptomatic/mild COVID-19.Methods: Forty young adults without previously known comorbidities/cardiovascular risk factors and with a confirmed diagnosis of asymptomatic or paucisymptomatic SARS-CoV-2 infection were retrospectively included. A 2D-transthoracic echocardiogram with speckle tracking analysis was performed at least 3 months after the diagnosis. Forty healthy subjects, matched for age, sex, and body surface area in a 1:1 ratio were used as the control group.Results: Left ventricular ejection fraction (LVEF), tricuspid annular plane systolic excursion (TAPSE) and RV-LS were comparable between the two groups. LV-GLS was significantly lower in the cases compared to the control group (−22.7 ± 1.6% vs. −25.7 ± 2.3%; p < .001). Moreover, the prevalence of regional peak systolic strain below −16% in at least two segments was three times higher in patients with previous COVID-19 compared to controls (30% vs. 10%, p = .02). In multivariable logistic regression, previous COVID-19 infection was independently associated with reduced LV-GLS values (p < .001). Conclusion:SARS-CoV-2 infection may affect left ventricular deformation in 30% of young adult patients despite an asymptomatic or only mildly symptomatic acute illness. Speckle-tracking echocardiography could help early identification of patients with subclinical cardiac involvement, with potential repercussions on risk stratification and management.

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Coronary tortuosity affects left ventricular myocardial functions: a 3D-speckle tracking echocardiography study

Cited by 12 publications

References 17 publications

Early Diagnosis of Abnormal Left Ventricular Systolic Functions of Rare Pathogenic Titin Mutation Gene Carriers in FHCM by Three-Dimensional Speckle Tracking Echocardiography Combined with Gene Detection

Early Diagnosis of Abnormal Left Ventricular Systolic Functions of Rare Pathogenic Titin Mutation Gene Carriers in FHCM by Three-Dimensional Speckle Tracking Echocardiography Combined with Gene Detection

Association of resting left ventricular global longitudinal strain with myocardial perfusion abnormalities evaluated by ¹³N‐ammonia positron emission tomography in patients with stable angina pectoris and normal left ventricular ejection fraction

The usefulness of speckle tracking echocardiography in identifying subclinical myocardial dysfunction in young adults recovered from mild COVID‐19

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Coronary tortuosity affects left ventricular myocardial functions: a 3D-speckle tracking echocardiography study

Cited by 12 publications

References 17 publications

Early Diagnosis of Abnormal Left Ventricular Systolic Functions of Rare Pathogenic Titin Mutation Gene Carriers in FHCM by Three-Dimensional Speckle Tracking Echocardiography Combined with Gene Detection

Early Diagnosis of Abnormal Left Ventricular Systolic Functions of Rare Pathogenic Titin Mutation Gene Carriers in FHCM by Three-Dimensional Speckle Tracking Echocardiography Combined with Gene Detection

Association of resting left ventricular global longitudinal strain with myocardial perfusion abnormalities evaluated by 13N‐ammonia positron emission tomography in patients with stable angina pectoris and normal left ventricular ejection fraction

The usefulness of speckle tracking echocardiography in identifying subclinical myocardial dysfunction in young adults recovered from mild COVID‐19

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Association of resting left ventricular global longitudinal strain with myocardial perfusion abnormalities evaluated by ¹³N‐ammonia positron emission tomography in patients with stable angina pectoris and normal left ventricular ejection fraction