Coronary thrombosis in a young male with COVID-19

Shams, Abdullah; Ata, Fateen; Mushtaq, Kamran; Munir, Waqar; Yousaf, Zohaib

doi:10.1016/j.idcr.2020.e00923

Cited by 18 publications

(12 citation statements)

References 10 publications

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“…Conversely there are also multiple reports of patients without traditional risk factors, but with COVID-19, presenting with STEMI with a high thrombus burden. 50 -52,56,58 -60 This observation underlies our suggestion that in patients without, or with few, risk factors presenting with high thrombus burden STEMI, there should be a high index of suspicion for COVID-19. 63 This suspicion should remain even if initial PCR testing is negative given the high false negative rates.…”

Section: Coronary Thrombus In Covid-19supporting

confidence: 54%

Therapeutic Implications of COVID-19 for the Interventional Cardiologist

Kelham

Choudry

Hamshere

et al. 2020

J Cardiovasc Pharmacol Ther

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Although COVID-19 is viewed primarily as a respiratory disease, cardiovascular risk factors and disease are prevalent among infected patients and are associated with worse outcomes. In addition, among multiple extra-pulmonary manifestations, there has been an increasing recognition of specific cardiovascular complications of COVID-19. Despite this, in the initial stages of the pandemic there was evidence of a reduction in patients presenting to acute cardiovascular services. In this masterclass review, with the aid of 2 exemplar cases, we will focus on the important therapeutic implications of COVID-19 for interventional cardiologists. We summarize the existing evidence base regarding the varied cardiovascular presentations seen in COVID-19 positive patients and the prognostic importance and potential mechanisms of acute myocardial injury in this setting. Importantly, through the use of a systematic review of the literature, we focus our discussion on the observed higher rates of coronary thrombus burden in patients with COVID-19 and acute coronary syndromes.

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Section: Coronary Thrombus In Covid-19supporting

confidence: 54%

Therapeutic Implications of COVID-19 for the Interventional Cardiologist

Kelham

Choudry

Hamshere

et al. 2020

J Cardiovasc Pharmacol Ther

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“…COVID-19 has been associated with significant cardiovascular complications due to direct effects of SARs-CoV-2 virus with significant effects of the virus on the expression and function of ACE-2 in the vasculature and evidence of coronary endothelial dysfunction and endothelialitis seen in multiple vascular beds in fatal patients www.nature.com/scientificreports/ with COVID-19 47,48 . Cases of acute coronary events (acute myocardial infarction and thromboembolism) triggered in patients with no underlying history of ischemic heart disease have been reported worldwide [49][50][51] . Statins are known to be effective in the prevention of endothelial dysfunction and downstream, atherosclerotic pathways and to prevent coronary artery disease 52 .…”

Section: Discussionmentioning

confidence: 99%

Statin use is associated with lower disease severity in COVID-19 infection

Tan

Young

Lye

et al. 2020

Sci Rep

101

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We aim to study the association of hyperlipidemia and statin use with COVID-19 severity. We analysed a retrospective cohort of 717 patients admitted to a tertiary centre in Singapore for COVID-19 infection. Clinical outcomes of interest were oxygen saturation ≤ 94% requiring supplemental oxygen, intensive-care unit (ICU) admission, invasive mechanical-ventilation and death. Patients on long term dyslipidaemia medications (statins, fibrates or ezetimibe) were considered to have dyslipidaemia. Logistic regression models were used to study the association between dyslipidaemia and clinical outcomes adjusted for age, gender and ethnicity. Statin treatment effect was determined, in a nested case–control design, through logistic treatment models with 1:3 propensity matching for age, gender and ethnicity. All statistical tests were two-sided, and statistical significance was taken as p < 0.05. One hundred fifty-six (21.8%) patients had dyslipidaemia and 97% of these were on statins. Logistic treatment models showed a lower chance of ICU admission for statin users when compared to non-statin users (ATET: Coeff (risk difference): − 0.12 (− 0.23, − 0.01); p = 0.028). There were no other significant differences in other outcomes. Statin use was independently associated with lower ICU admission. This supports current practice to continue prescription of statins in COVID-19 patients.

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“…and successfully managed with PPCI. 17 Salido-Tahoces et al. reported another positive case of COVID-19 in a 62-year-old male who presented with asthenia and recurrent chest pain with ACS and proximal RCA stenosis and whose diagnosis was confirmed by CAG.…”

Section: Discussionmentioning

confidence: 97%

An unusual and atypical presentation of the novel coronavirus: A case report and brief review of the literature

Alshoabi

Haider

Mostafa

et al. 2021

Journal of Taibah University Medical Sciences

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The coronavirus disease 2019 (COVID-19) is a highly contagious novel infection that predominantly presents with fever and respiratory symptoms. However, COVID-19 can masquerade as an acute coronary syndrome, leg pain or swelling with venous thrombosis, loss of consciousness with cerebral venous thrombosis, confusion, limb weakness with brain infarction, facial neuralgia, acute conjunctivitis, acute appendicitis, and testicular pain. We report on a 42-year-old man who presented with mild symptoms of COVID-19. The patient's electrocardiogram showed an ST-segment elevation myocardial infarction (STEMI) due to a left coronary thrombosis. The patient was managed conservatively with medicines and had an uneventful recovery. Emergency physicians should have a high index of suspicion for the unusual presentations of COVID-19.

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Coronary thrombosis in a young male with COVID-19

Cited by 18 publications

References 10 publications

Therapeutic Implications of COVID-19 for the Interventional Cardiologist

Therapeutic Implications of COVID-19 for the Interventional Cardiologist

Statin use is associated with lower disease severity in COVID-19 infection

An unusual and atypical presentation of the novel coronavirus: A case report and brief review of the literature

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