Coronary sinus blood sampling: an insight into local cardiac pathophysiology and treatment?

Abstract

Atherosclerosis remains the underlying cause of cardiovascular disease and is a dynamic process involving inflammation, haemostasis, endothelial dysfunction, and angiogenesis. Studies of circulating factors from peripheral blood can provide an insight into this pathophysiology but may remain indicative of a more generalized, systemic process. More localized interaction(s) within the heart may be better studied from coronary blood samples. Indeed, an increasing number of prospective studies show good correlation between indices of these processes and clinical outcomes. As local sampling offers a unique way of assessing the local cardiac milieu, this may prove useful in the monitoring of both local/systemic drug therapies and interventional technologies.

Potassium Concentration in Cardioplegic Solutions in Pediatric Patients Undergoing Tetralogy of Fallot Repair: Impact on Myocardial Protection

“…Among other changes, cardiac arrest induces a period of obligate myocardial lactate production that persists for an indeterminate amount of time after reperfusion. Coronary sinus lactate assays have been established as a standard method to compare various myocardial protection strategies [25,26].…”

Selection of Target Area for Interventional and Cell Therapy after Myocardial Infarction Using 3d Echocardiography

“…When standard imagistic techniques like SPECT or PET are not available, computerized 3D echocardiography could represent an alternative to identify areas of viable myocardium as a target area for intervention [2,4,6]. …”

“…Different research teams are trying to identify innovative therapies for myocardial salvage and recovery of hibernated myocardium (viable myocardium located at the border area of infarction, with decreased metabolism)[7]. One of these methods is hematopoietic stem cells intracoronarian injection [5,8].When standard imagistic techniques like SPECT or PET are not available, computerized 3D echocardiography could represent an alternative to identify areas of viable myocardium as a target area for intervention [2,4,6]. 978-0-7695-3621-7/09 $25.00…”

Análise comparativa entre a proteína C-reativa de alta sensibilidade em veia periférica e seio coronário na angina estável e instável

“…Tais fatos poderiam ter implicações futuras em clínica e pesquisa, de modo a evitar técnicas invasivas para coleta de amostra de sangue no SC, até o momento considerado o local ideal para estudos de marcadores inflamatórios e circulação coronária 23 , por meio de cateter e como via de acesso, veias: jugular, braquial ou femoral. Pois, este estudo sugeriu uma forte correlação linear entre os níveis séricos absolutos de PCR-as encontrados em VPAE vs.…”

“…Com os dados do nosso estudo, ao contrário de outros autores 23,117 , constatou-se que os níveis séricos absolutos de PCR-as na VPAE, refletiram os níveis no SC, portanto, na circulação coronária.…”