Coronary revascularization in a 13 year old patient with homozygous familial hypercholesterolemia

Abstract

Ailesel homozigot hiperkolesterolemi düşük yoğunluklu lipoprotein reseptör gen mutasyonlarından kaynaklanan otozomal dominant bir hastalıktır. Hastalık erken yaşta koroner arter hastalığı gelişme riskinde artış ile ilişkilidir. Bu yazıda, yaygın koroner arter hastalığı ve ailesel homozigot hiperkolesterolemisi olan ve başarılı koroner arter baypas greft cerrahisi yapılan 13 yaşında bir erkek olgu sunuldu. Anah tar söz cük ler: Koroner arter hastalığı; koroner baypas arter greftleme; ailesel hiperkolesterolemi; cerrahi. Homozygous familial hypercholesterolemia is an autosomal dominant disorder caused by mutations in the low density lipoprotein receptor gene. The disease is associated with an increased risk of coronary artery disease early in life. In this article, we present a 13-year-old boy with familial homozygous hypercholesterolemia who had an extensive coronary artery disease and underwent successful coronary artery bypass graft surgery.

Heterozygous Familial Hypercholesterolemia With APOE Haplotype: A Prospective Harbinger of a Catastrophic Cardiovascular Event

“…CABG in young FH patient is challenging and very seldom in the first and second decade though feasible and has good outcomes. Two cases have been reported of a 13- and a 14-year-old boy with FH who underwent triple-vessel CABG utilizing bilateral internal thoracic artery and saphenous vein grafting devoid of unfavorable events [ 20 , 21 ]. The role of CABG in FH patients with documented CAD has been elucidated in literature.…”

Ten-year follow-up of coronary revascularization in a pediatric case with homozygous familial hypercholesterolemia

“…[8,9] Living-related liver transplants soon came to account for a substantial number of pediatric cases performed in many centers throughout the world, and the only possibility for liver transplants in countries, where cadaveric organ procurement was not allowed until a few years ago.…”