Coronary Microvascular function, Peripheral Endothelial Function and Carotid IMT in beta-thalassemia minor

Güllü, Hakan; Çalışkan, Mustafa; Çalışkan, Zuhal; Unler, Gulhan Kanat; Ermisler, Eda; Çiftçi, Özgür; Güven, Aytekin; Müderrisoğlu, Haldun

doi:10.1016/j.thromres.2013.03.013

Cited by 12 publications

(17 citation statements)

References 46 publications

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“…But CIMT of right lateral wall left posterior wall and left lateral wall were comparable between patients and control group. This was in line with previous studies which found increased carotid CIMT in patients with b-TM as compared with healthy subjects [7,9,15,16,[18][19][20][21][22]. Gursel and colleagues showed that CIMT in patients with b-TM aged 11 years or less was increased compared with healthy controls in the same age group.…”

Section: Discussionsupporting

confidence: 91%

Carotid Doppler ultrasonography as a screening tool of early atherosclerotic changes in children and young adults with β-thalassemia major

et al. 2017

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Section: Discussionsupporting

confidence: 91%

Carotid Doppler ultrasonography as a screening tool of early atherosclerotic changes in children and young adults with β-thalassemia major

et al. 2017

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“…In our study, there was significant statistical correlation between CIMT and patient’s age, ferritin, and total cholesterol levels but there was no significant difference of CIMT in relation to patient’s hemoglobin level. This also comes in harmony with the study of Tantawy et al17 who reported that in thalassemic patients, CIMT was positively correlated with age, ferritin and cholesterol levels, and that atherogenic lipid profiles in young thalassemic patients with increased CIMT highlights their importance as prognostic factors for vascular risk stratification. These findings are further supported by Gursel et al,22 who investigated the relationship between chronic hemolysis and increased body iron burden and the development of premature atherosclerosis by using CIMT, ferritin, serum lipid profile.…”

Section: Discussionsupporting

confidence: 86%

“…Our data show that the CIMT of thalassemic patients was significantly increased compared to controls. This finding is supported by the results of some previous studies;16–18 Cheung et al,19 found an increase in the CIMT in patients with BTM compared to controls, Tantawy et al, 200917 and Gullu et al,18 found the same results in their study, and Adly et al19 reported that Carotid IMT measurements were significantly but slightly higher in the BTM group than that in the controls (0.57 ± 0.07 vs. 0.54 ± 0.04, P = 0.04) and that CIMT is increased in patients with BTM. On the other hand, a previous study, carried out by Cusmà et al,20 comparing the CIMT between the thalassemic patients and healthy subjects (0.67 ± 0.20 mm vs. 0.66 ± 0.15 mm), showed no significant difference.…”

Section: Discussionsupporting

confidence: 78%

The Role of the Carotid Doppler Examination in the Evaluation of Atherosclerotic Changes in Beta Thalassemia Patients

Hakeem

Samei

Shereif

et al. 2015

Mediterr J Hematol Infect Dis

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BackgroundIron overload in patients with beta-thalassemia major (BTM) lead to alterations in the arterial structures and the thickness of the carotid arteries. Doppler ultrasound scanning of extra-cranial internal carotid arteries is non-invasive and relatively quick to perform and may identify children at increased risk of stroke that would otherwise be missed. Increased carotid artery intima media thickness (CIMT) is a structural marker for early atherosclerosis and correlates with the vascular risk factors and to the severity and extent of coronary artery disease.ObjectiveTo evaluate the role of carotid Doppler examination and CIMT measurement as a predictor of atherosclerotic changes in BTM children with iron overload.Patients and MethodsSixty two children with BTM and, thirty age and sex matched normal controls were included. Complete blood count, ferritin, serum cholesterol were done, as well as carotid Doppler ultrasonography to measure the CIMT in both patients and controls.ResultsCIMT of thalassemic patients was significantly increased compared to controls (p=0.001). There was a significant positive correlation between CIMT and patient’s age, the duration from first blood transfusion, serum cholesterol and, iron overload parameters as serum ferritin, frequency of blood transfusion, iron chelation. The length of the transfusion period was the highest risk factor, and an inadequate iron chelation was a further risk factor. Significant negative correlation was found between CIMT and hematocrit value while no significant correlation was found between CIMT and weight, height, BMI centiles and Hb level.ConclusionCarotid Doppler is very useful in measurement of CIMT that increased in thalassemic patients that shows a strong relationship with features of iron overload. Routine Doppler measurement of CIMT in these patients is recommended to predict early atherosclerotic changes as well as in follow-up.

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“…Childhood exposure to O3 may be a novel risk factor for CIMT in a healthy population of college students [ 143 ]. Additionally, higher CIMT was associated with the development of chronic kidney disease [ 144 ], growth hormone deficiency [ 145 ], beta-thalassemia minor [ 146 ], preeclampsia [ 142 ] and menopause transition [ 147 ]. However, recent studies could not show associations of elevated parathyroid hormone (PTH) concentrations [ 136 ] and normal-tension glaucoma [ 48 ] with altered CIMT.…”

Section: The Associations Between Cimt and Novel Risk Factorsmentioning

confidence: 99%

Causes of changes in carotid intima-media thickness: a literature review

2015

Cardiovasc Ultrasound

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Atherosclerosis causes significant morbidity and mortality. Carotid intima-media thickness (CIMT) predicts future cardiovascular and ischaemic stroke incidence. CIMT, a measure of atherosclerotic disease, can be reliably determined in vivo by carotid ultrasound. In this review, we determined that CIMT is associated with traditional cardiovascular risk factors such as age, sex, race, smoking, alcohol consumption, habitual endurance exercise, blood pressure, dyslipidemia, dietary patterns, risk-lowering drug therapy, glycemia, hyperuricemia, obesity-related anthropometric parameters, obesity and obesity-related diseases. We also found that CIMT is associated with novel risk factors, including heredity, certain genotypic indices, anthropometric cardiovascular parameters, rheumatoid arthritis, immunological diseases, inflammatory cytokines, lipid peroxidation, anthropometric hemocyte parameters, infectious diseases, vitamin D, matrix metalloproteinases, and other novel factors and diseases. However, the conclusions are inconsonant; the underlying causes of these associations remain to be further explored.

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Coronary Microvascular function, Peripheral Endothelial Function and Carotid IMT in beta-thalassemia minor

Cited by 12 publications

References 46 publications

Carotid Doppler ultrasonography as a screening tool of early atherosclerotic changes in children and young adults with β-thalassemia major

Carotid Doppler ultrasonography as a screening tool of early atherosclerotic changes in children and young adults with β-thalassemia major

The Role of the Carotid Doppler Examination in the Evaluation of Atherosclerotic Changes in Beta Thalassemia Patients

Causes of changes in carotid intima-media thickness: a literature review

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