Coronary Heart Disease, Serum Lipids, Platelets and Dietary Fish in Two Communities in Northern Norway

Simonsen, Terje; Vårtun, Åse; Lyngmo, V.; Nordøy, Arne

doi:10.1111/j.0954-6820.1987.tb10665.x

Cited by 71 publications

(8 citation statements)

References 27 publications

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“…Furthermore, the addition of 12-LOX products (12-HETE and 12-HPETE) to human islets resulted in a decrease in glucose-stimulated insulin secretion associated with a decrease in islet viability (Persaud et al, 2007), and a partial restoration in glucose-stimulated insulin secretion if 12HETE was combined with lisofylline, an inhibitor of IL-12 signaling. Collectively these data support a predicted role of IL-12 in mediating the immune damage caused by the 12-LOX pathway (Simonsen et al, 1987; Vidgren et al, 1997; Vognild et al, 1998). …”

Section: Oxylipins and Diabetessupporting

confidence: 76%

The emerging role of oxylipins in thrombosis and diabetes

2014

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The prevalence of cardiovascular disease (CVD), the leading cause of death in the US, is predicted to increase due to the shift in age of the general population and increase in CVD risk factors such as obesity and diabetes. New therapies are required to decrease the prevalence of CVD risk factors (obesity and diabetes) as well as reduce atherothrombosis, the major cause of CVD related mortality. Oxylipins, bioactive metabolites derived from the oxygenation of polyunsaturated fatty acids, play a role in the progression of CVD risk factors and thrombosis. Aspirin, a cyclooxygenase-1 inhibitor, decreases atherothrombotic associated mortality by 25%. These potent effects of aspirin have shown the utility of modulating oxylipin signaling pathways to decrease CVD mortality. The role of many oxylipins in the progression of CVD, however, is still uncertain or controversial. An increased understanding of the role oxylipins play in CVD risk factors and thrombosis could lead to new therapies to decrease the prevalence of CVD and its associated mortality.

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Section: Oxylipins and Diabetessupporting

confidence: 76%

The emerging role of oxylipins in thrombosis and diabetes

2014

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“…These include improved triglycerides, 44 anti-inflammatory, antithrombotic and antiatherogenic effects of fish oil. 59 Of further interest, a lower prevalence of diabetes [60][61][62][63][64] and glucose intolerance 65 have been reported in populations known to have a very high omega-3 fatty acid intake (for example, Greenland, Alaska, Faroe Islands). An inverse correlation between omega-3 intake and conditions such as diabetes and glucose intolerance has been observed in an elderly Dutch population.…”

Section: Introductionmentioning

confidence: 99%

Omega-3 fatty acids: a review of the effects on adiponectin and leptin and potential implications for obesity management

et al. 2013

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An increase in adiposity is associated with altered levels of biologically active proteins. These include the hormones adiponectin and leptin. The marked change in circulating concentrations of these hormones in obesity has been associated with the development of insulin resistance and metabolic syndrome. Variations in dietary lipid consumption have also been shown to impact obesity. Specifically, omega-3 fatty acids have been correlated with the prevention of obesity and subsequent development of chronic disease sequalae. This review explores animal and human data relating to the effects of omega-3 fatty acids (marine lipids) on adiponectin and leptin, considering plausible mechanisms and potential implications for obesity management. Current evidence suggests a positive, dose-dependent relationship between omega-3 fatty acid intake and circulating levels of adiponectin. In obese subjects, this may translate into a reduced risk of developing cardiovascular disease, metabolic syndrome and diabetes. In non-obese subjects, omega-3 is observed to decrease circulating levels of leptin; however, omega-3-associated increases in leptin levels have been observed in obese subjects. This may pose benefits in the prevention of weight regain in these subjects following calorie restriction.

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“…On the other hand there is low prevalence of diabetes in Greenland [6] and Alaskan Eskimos [7] as well in people living in the Faeroe Islands [8], populations known for a very high intake of omega-3 fatty acids. The prevalence of diabetes mellitus in Alaska has found that 15.7/1000 subject was lower than over United States vat of 24.7/1000 and 8.8/1000 among Alaskan Eskimos [9].…”

Section: Introductionmentioning

confidence: 99%

The Effects of Varieties Sources of Omega-3 Fatty Acids on Diabetes in Rats

Soltan¹

2012

FNS

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The aim of this study was to investigate the effects of varieties sources of omega-3 on diabetic rats. Fifty six male albi-no rats were divided into 7 group: first group was fed on normal basal diet (maintained at negative control group), group 2 diabetic group fed on 60% fructose, group 3 fed on 60% fructose + 8% fish oil, group 4 fed on 60% fructose + 8% flaxseed oil, group 5 fed on 60% fructose + 4% corn oil + 4% fish oil, group 6 fed on 60% fructose + 4% corn oil + 4% flaxseed oil and group 7 fed on 60% fructose + 4% fish oil + 4% flaxseed oil. Fatty acid composition of investigated oils show that the corn oil contained high levels of omega-6 fatty acid (LA: 56.95%), flaxseed oil contained high level of short chain omega-3 fatty acid (ALA: 56.31%), meanwhile fish oil only has high concentration of long chain omega-3 fatty acid 39.20% (23.98% of EPA and 15.22% of DHA). After 8 week feeding of fish oil, flaxseed oil, corn oil + fish oil, corn oil + flaxseed oil and fish oil + flaxseed oil show reduces levels of glucose by 49.09%, 44.0%, 43.4%. 43.6% and 44.9% respectively. Data revealed significant decrease (P < 0.05%) was observed of TC, TG, LDL and VLDL of all treatment. Urea and creatinine in diabetic rats was increase, in contrast the glutathione reduced was decrease compared to the control group. Fish oil show the highest decrease in urea and creatinene and the highest increase in glutathione levels and insulin compared to other sources of omega-3. Omega-3 fatty acids have potential effect to protect pancreas from up normality changes which induced in diabetic disease. The data suggest that omega-3 fatty acid and fish oil especially may be effective in the prevention of diabetic disease

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Coronary Heart Disease, Serum Lipids, Platelets and Dietary Fish in Two Communities in Northern Norway

Cited by 71 publications

References 27 publications

The emerging role of oxylipins in thrombosis and diabetes

The emerging role of oxylipins in thrombosis and diabetes

Omega-3 fatty acids: a review of the effects on adiponectin and leptin and potential implications for obesity management

The Effects of Varieties Sources of Omega-3 Fatty Acids on Diabetes in Rats

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