Coronary heart disease mortality in China: age, gender, and urban-rural gaps during epidemiological transition

Jiang, Guohong; Wang, Dezheng; Li, Wei; Pan, Yongsheng; Zheng, Wenjun; Zhang, Hui; Sun, Yan

doi:10.1590/s1020-49892012000400008

Cited by 57 publications

(50 citation statements)

References 20 publications

(19 reference statements)

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“…Moreover, one patient with CHD will die every 1.3 min in the USA [3]. In China, the mortality of CHD occurring outside hospitals is higher than 50% [4,5].…”

Section: Introductionmentioning

confidence: 99%

Astragaloside IV Improves Vasodilatation Function by Regulating the PI3K/Akt/eNOS Signaling Pathway in Rat Aorta Endothelial Cells

et al. 2018

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Coronary heart disease (CHD) remains a major public health burden. Endothelial-dependent coronary artery vasoreactivity is a significant indicator of vascular function. Endothelial dysfunction is characterized by decreased nitric oxide (NO) bioavailability and predicts late cardiovascular events. Astragaloside IV (AGIV) is the main active component of the herb Astragalus membranaceus. Although it shows a significant protective effect against vascular endothelial dysfunction, the mechanisms of AGIV promoting the vascular dilation have not been elucidated. This study investigated the vasodilator effect of AGIV on rat aortic rings and the underlying effect of AGIV via the PI3K/Akt/eNOS signaling pathway. We measured the relaxation of isolated RARs after different concentrations of AGIV treatment. Rat aorta endothelial cells were cultured with different doses of AGIV, dimethylsulfoxide, and NG-nitro L-arginine methyl ester. The expression of phosphorylated (p)-Akt and -endothelial nitric oxide synthase (p-eNOS) were tested by Western blot analysis. The messenger (m)RNA expression of eNOS was quantified by real-time polymerase chain reaction. AGIV exerted a vasodilator effect on the aortic rings and increased the NO content in a concentration-dependent manner. The vasorelaxation was suppressed by an eNOS inhibitor. AGIV regulated the PI3K/Akt/eNOS signaling pathway via phosphorylation of Akt at Ser⁴⁷³ and dephosphorylation of eNOS at Thr⁴⁹⁵. The mRNA expression of eNOS was remarkably upregulated by AGIV. AGIV significantly induced the dilation of the aortic rings, leading to the vasodilator response by enhancing the eNOS release via the PI3K/Akt/eNOS signaling pathway.

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“…Moreover, one patient with CHD will die every 1.3 min in the USA [3]. In China, the mortality of CHD occurring outside hospitals is higher than 50% [4,5].…”

Section: Introductionmentioning

confidence: 99%

Astragaloside IV Improves Vasodilatation Function by Regulating the PI3K/Akt/eNOS Signaling Pathway in Rat Aorta Endothelial Cells

et al. 2018

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“…It is estimated that it will become the primary disease endangering human health in the world (Lopez and Mathers, 2006). According to a study report ( Jiang et al, 2012), CHD death rate has increased from 16% to 24% in China since the year 2008. CHD is a chronic complex disease with strong genetic components.…”

Section: Introductionmentioning

confidence: 99%

Association Between Apolipoprotein B XbaI Polymorphism and Coronary Heart Disease in Han Chinese Population: A Meta-Analysis

Chen

Lin

Liang³

et al. 2016

Genetic Testing and Molecular Biomarkers

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Objective: To examine the association between apolipoprotein B (ApoB) XbaI polymorphisms (rs693) and coronary heart disease (CHD) risk among the Han Chinese population by systematically analyzing multiple independent studies. Methods: The Hardy-Weinberg equilibrium test was applied to check genetic equilibrium among genotypes for the selected literatures. The quality of the studies was assessed by using the NewcastleOttawa Scale. Power analysis was performed with Power and Precision V4 software. A fixed or random effect model was used on the basis of heterogeneity. Publication bias was quantified and examined with Begg's funnel plot test and Egger's linear regression test. The meta-analysis was performed by Stata 12.0 software. Results: A total of 10 eligible association studies were included in this meta-analysis, and the pooled sample consisted of 1195 CHD patients and 1178 health controls. No consistent inference regarding publication bias for the included studies was obtained by using the two above-mentioned methods.

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“…However, in China, CAD has become a public health problem in the past few decades. The overall CAD mortality rate (per 100,000 individuals per year) in China rose from 95.3 in 1999 to 103.4 in 2008 (Jiang et al, 2012). In 2008, the crude morbidity rate of ischemic heart disease was 12.7% among Chinese urban residents (Li et al, 2013a).…”

Section: Introductionmentioning

confidence: 99%

Review APOA5 -1131T/C polymorphism and coronary artery disease susceptibility in Chinese population: an updated meta-analysis

Zhang¹,

Dg²,

Hl³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Although many studies have investigated the association of the APOA5 -1131T/C polymorphism with coronary artery disease (CAD), definite conclusions have not been drawn. To understand the effects of the APOA5 -1131T/C polymorphism on the risk of developing CAD, we performed an updated meta-analysis in the Chinese population. Relevant studies published till April 2015 were identified from databases such as PubMed, Springer Link, Ovid, Chinese Wanfang Data Knowledge Service Platform, Chinese National Knowledge Infrastructure, and Chinese Biology Medicine. A total of 19 studies including 3983 patients and 4358 controls were involved in this meta-analysis. The crude OR with 95%CI was calculated to assess the strength of the association. With the pooled data from the studies included in this meta-analysis, we found a significant association between the APOA5 -1131T/C polymorphism and CAD risk in 12330-12339 (2015) according to the geographical location and source of controls revealed significantly increased risk in South China and in population-based studies.In conclusion, our meta-analysis provides substantial evidence that the APOA5 -1131T/C polymorphism might contribute to CAD development in the Chinese population.

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Coronary heart disease mortality in China: age, gender, and urban-rural gaps during epidemiological transition

Cited by 57 publications

References 20 publications

Astragaloside IV Improves Vasodilatation Function by Regulating the PI3K/Akt/eNOS Signaling Pathway in Rat Aorta Endothelial Cells

Astragaloside IV Improves Vasodilatation Function by Regulating the PI3K/Akt/eNOS Signaling Pathway in Rat Aorta Endothelial Cells

Association Between Apolipoprotein B XbaI Polymorphism and Coronary Heart Disease in Han Chinese Population: A Meta-Analysis

Review APOA5 -1131T/C polymorphism and coronary artery disease susceptibility in Chinese population: an updated meta-analysis

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