Coronary Heart Disease in Women: A Challenge for the 21st Century

Solimene, Maria Cecilia

doi:10.1590/s1807-59322010000100015

Cited by 47 publications

(41 citation statements)

References 40 publications

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“…The management of cardiorespiratory function in overweight/obese women is one of the challenges facing the 21 st century 40. Our study found that overweight/obese postmenopausal women display an impaired HR response to exercise and an impairment in the exercise-induced improvement in CRF and HR RECOVERY compared to normal-weight women.…”

Section: Discussionmentioning

confidence: 54%

Exercise-induced improvements in cardiorespiratory fitness and heart rate response to exercise are impaired in overweight/obese postmenopausal women

Ciolac

Greve

2011

Clinics

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OBJECTIVE:The purpose of this study was to compare the heart rate response to exercise and the exercise-induced improvements in muscle strength, cardiorespiratory fitness and heart rate response between normal-weight and overweight/obese postmenopausal women.METHODS:Sedentary women (n = 155) were divided into normal-weight (n = 79; BMI <25 kg/m2; 58.3±8.6 years) and overweight/obese (n = 76; BMI ≥25 kg/m2; 58.3±8.6 years) groups, and have their 1-repetition maximum strength (adjusted for body mass), cardiorespiratory fitness and heart rate response to a graded exercise test compared before and after 12 months of a three times-per-week exercise-training program.RESULTS:Overweight/obese women displayed decreased upper and lower extremity muscle strengths, decreased cardiorespiratory fitness, and lower peak and reserve heart rates compared to normal-weight women. After follow-up, both groups improved their upper (32.9% and 41.5% in normal-weight and overweight/obese women, respectively) and lower extremity(49.5% and 47.8% in normal-weight and overweight/obese women, respectively) muscle strength. However, only normal-weight women improved their cardiorespiratory fitness (6.6%) and recovery heart rate (5 bpm). Resting, reserve and peak heart rates did not change in either group.CONCLUSIONS:Overweight/obese women displayed impaired heart rate response to exercise. Both groups improved muscle strength, but only normal-weight women improved cardiorespiratory fitness and heart rate response to exercise. These results suggest that exercise-induced improvements in cardiorespiratory fitness and heart rate response to exercise may be impaired in overweight/obese postmenopausal women.

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Section: Discussionmentioning

confidence: 54%

Exercise-induced improvements in cardiorespiratory fitness and heart rate response to exercise are impaired in overweight/obese postmenopausal women

Ciolac

Greve

2011

Clinics

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“…9) However, symptoms among younger women were atypical, and patients with silent myocardial ischemia usually had more extensive and severe disease. 10,11) A previous study also indicated that young women were more likely to have CAD without chest pain. 12) Another study in a Canadian cohort of patients whose age was under 55 years with acute coronary syndrome supported this pattern.…”

Section: Discussionmentioning

confidence: 95%

Coronary Artery Disease in Premenopausal and Postmenopausal Women

Jiang

Dong-shen³

2017

Int. Heart J.

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SummaryThe purpose was to determine the differences between premenopausal and postmenopausal coronary artery disease (CAD) risk factors, clinical manifestation, cardiovascular features, rates of recurrence, and influencing factors.Premenopausal (n = 57) and postmenopausal (n = 178) CAD women hospitalized during the same period were enrolled. All patients were followed-up, and the combined recurrence of major adverse cardiovascular events was recorded as the clinical outcome. Differences were compared between the 2 groups.Fewer premenopausal women suffered from hypertension (43.86% versus 75.28%, P < 0.001), type 2 diabetes (12.28% versus 35.96%, P = 0.001), and hyperlipidemia (5.26% versus 34.83%, P < 0.001), but more had a positive family history of premature CAD (40.35% versus 25.28%, P = 0.03). Acute coronary syndrome (ACS) was more frequently seen in premenopausal women (82.46% versus 48.88%, P < 0.001), and their left anterior descending branch was the vessel most often involved (65.33%). The cumulative recurrence rate was 1.76 times higher in postmenopausal patients than premenopausal patients. Clinical diagnosis (HR = 2.54, 95%CI: 1.21-4.85, P = 0.02) and type 2 diabetes (HR = 4.10, 95%CI: 2.37-8.83, P = 0.004) were two factors that influenced recurrence in premenopausal subjects, while the clinical diagnosis (HR = 1.93, 95%CI: 1.59-3.46, P = 0.03) and Gensini score (HR = 1.20, 95%CI: 1.11-1.45, P = 0.02) were influencing factors in the postmenopausal patients.Symptoms among younger women were atypical, but the onset of disease was faster and more urgent, and angiography in premenopausal women might underestimate the severity of disease. The risk factors, rate of recurrence, and influencing factors were different between premenopausal and postmenopausal patients. (Int Heart J 2017; 58: 174-179)

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“…Compared with women, men exhibit higher prevalence of cardiovascular disorders, especially CAD 36. However, the rate of coronary death is twice as high in women as in men after MI and revascularisation procedures 37. Also, men have a higher risk of developing diabetes compared with their female counterparts 2.…”

Section: Common Antecedents Of Type 2 Diabetes and Cvdmentioning

confidence: 99%

Type 2 diabetes and cardiovascular diseases: do they share a common soil? The Asian Indian experience

2012

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In India, diabetes and cardiovascular disease (CVD) are growing health problems. CVD accounts for much of the increased morbidity and premature mortality associated with type 2 diabetes. Moreover, CVD also occurs 2-3 decades earlier among diabetic subjects and runs a more aggressive course and has a worse prognosis. The pathophysiology of the link between diabetes and CVD is complex and multifactorial and understanding the mechanisms of the disease can help identify and treat CVD in patients with diabetes and vice versa. The current article reviews the common antecedents between type 2 diabetes and CVD including non-modifiable and modifiable risk factors and suggests that future research on diabetes and CVD should focus on searching for risk factors for CVD that may be more specific to diabetes, such as hypoglycaemia or medication related comorbidities. Also, the authors recommend research on common genetic variants which might have stronger effects and hence have a potential role in diabetes and CVD risk prediction. Finally, primary prevention trials trying to prevent both diabetes and CVD are the urgent need of the hour!

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Coronary Heart Disease in Women: A Challenge for the 21st Century

Cited by 47 publications

References 40 publications

Exercise-induced improvements in cardiorespiratory fitness and heart rate response to exercise are impaired in overweight/obese postmenopausal women

Exercise-induced improvements in cardiorespiratory fitness and heart rate response to exercise are impaired in overweight/obese postmenopausal women

Coronary Artery Disease in Premenopausal and Postmenopausal Women

Type 2 diabetes and cardiovascular diseases: do they share a common soil? The Asian Indian experience

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