Coronary heart disease in identical female twins

Benedict, Ruth B.

doi:10.1016/0002-9343(58)90383-8

Cited by 26 publications

(3 citation statements)

References 6 publications

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“…Clinical and population-based studies have subsequently demonstrated that genetic factors play important roles in CAD/MI [18–27]. Twin studies estimated the heritability of CAD/MI to be approximately 50 to 60% [3–8]. Understanding the genetic basis of CHD/MI will not only help to understand the pathogenesis of the disease, but also lay the foundation for the development of precise prevention and treatment strategies [28].…”

Section: Discussionmentioning

confidence: 99%

“…Coronary artery disease (CAD) is projected to become the dominant cause of death and disability worldwide by 2020 [1]. Although reduction of traditional risk factors for CAD is associated with 30 to 40% less adverse events such as death and myocardial infarction (MI) [2], residual cardiovascular risk is a challenge due to the genetic predisposition [3–8]. In recent years, some significant progress has been made in identifying genes that are associated with susceptibility to the development of CAD/MI.…”

Section: Introductionmentioning

confidence: 99%

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First-degree relatives with similar phenotypic characterisation of acute myocardial infarction: a case report and review of the literature

Ohene

Yang

et al. 2019

BMC Cardiovasc Disord

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BackgroundGenetic susceptibility to the development of coronary artery disease (CAD) and myocardial infarction (MI) is well established. However, lack of replication, and difficulty in the identification of specific genes that underlie impressive linkage peaks remain challenges at the molecular level due to the heterogeneity of phenotype and their associated genotypes. We present two cases of first-degree family members of acute myocardial infarction (AMI) having similar clinical and angiographic features of obstructive coronary lesions at same anatomic locations.Case presentationThe father presented with significant chest discomfort and loss of consciousness. The electrocardiogram (ECG) showed an acute anterior ST-segment–elevation myocardial infarction (STEMI). Coronary angiogram demonstrated a subtotal occlusion in the mid-left anterior descending (LAD) coronary artery. One week later, the son presented after an in-hospital cardiac arrest with pulseless electric activity preceded by significant chest pain and loss of consciousness. His ECG also showed an acute anterior STEMI. Catheterization revealed strikingly similar angiographic characteristics with his father: subtotal occlusion in the proximal to mid-LAD coronary artery.ConclusionsMore considerations should be given to patients with similar phenotypic characterization in genetic studies of CAD/MI in the future.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

First-degree relatives with similar phenotypic characterisation of acute myocardial infarction: a case report and review of the literature

Ohene

Yang

et al. 2019

BMC Cardiovasc Disord

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“…The results also imply that the genetic effect decreases at older ages. Benedict (1958) described a set of twins with CAD. His report mentioned several points of interest including young age, similar electrocardiogram changes and development of coronary events with a small difference in time (6 months).…”

Section: Discussionmentioning

confidence: 99%

Different Clinical and Angiographic Finding in a Set of Iranian Identical Twin: A Case Report

Shojaie¹

2013

OnLine Journal of Biological Sciences

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Both genetic and environmental causes are involved in developing of Coronary Artery Disease (CAD), but there is a notable controversy about the environmental and genetic factors that play a role in the pathogenesis of CAD. The value of each individual risk factor on CAD and the incidence of coronary artery disease in identical twins are indefinite. To find out genetic mechanisms of coronary heart disease, the assessment of twins study may help us. On the other hand the natural history of coronary artery disease in an asymptomatic twin with a symptomatic counterpart is undistinguishable. We present a case report about different coronary angiographic findings on an Iranian identical Lady Twin with different clinical outcome in access to incidence of CAD in twins. Based on our patient and the information on other patients, the asymptomatic twins of symptomatic counterparts need aggressive assessment and management for occult coronary artery disease.

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Premature Coronary Artery Disease in Identical Male Twins Studied by Selective Coronary Arteriography

Kreulen

Cohn

Gorlin

1975

Cathet. Cardiovasc. Diagn.

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Coronary heart disease in identical female twins

Cited by 26 publications

References 6 publications

First-degree relatives with similar phenotypic characterisation of acute myocardial infarction: a case report and review of the literature

First-degree relatives with similar phenotypic characterisation of acute myocardial infarction: a case report and review of the literature

Different Clinical and Angiographic Finding in a Set of Iranian Identical Twin: A Case Report

Premature Coronary Artery Disease in Identical Male Twins Studied by Selective Coronary Arteriography

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