Coronary Flow Reserve Predicts Cardiopulmonary Fitness in Patients with Coronary Artery Disease Independently of Systolic and Diastolic Function

Snoer, Martin; Olsen, Rasmus Huan; Monk-Hansen, Tea; Pedersen, Lene Roerholm; Haugaard, Steen B.; Dela, Flemming; Prescott, Eva

doi:10.1111/echo.12445

Cited by 11 publications

(6 citation statements)

References 30 publications

(82 reference statements)

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“…However, in the present study of patients with no obstructive CAD, we found no association between CMD and filling pressure. In patients with CAD (n = 40), heart failure with reduced LVEF (n = 47), and in patients with diabetes (n = 67), CMD has been shown to correlate with indices of LV diastolic dysfunction or/and high LV filling pressure . Further, a study including patients with angina, no coronary artery stenosis, and preserved LVEF showed that those with diastolic heart failure (n = 155) had a more impaired coronary microcirculation determined by angiographic indices than those without heart failure (n = 131), although the authors did not adjust for differences in cardiovascular risk factors between groups .…”

Section: Discussionmentioning

confidence: 99%

Coronary microvascular dysfunction and myocardial contractile reserve in women with angina and no obstructive coronary artery disease

et al. 2017

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Section: Discussionmentioning

confidence: 99%

Coronary microvascular dysfunction and myocardial contractile reserve in women with angina and no obstructive coronary artery disease

et al. 2017

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“…As with albuminuria, CFR may be a summary measure of microvascular injury due to multiple risk factors including diabetes. Furthermore, CFR is also associated with LV diastolic dysfunction in patients with arterial hypertension [ 41 ] and coronary artery disease [ 42 ], and an association between CFR and LV diastolic function may also occur in patients with various coronary risk factors.…”

Section: Discussionmentioning

confidence: 99%

Coronary microvascular function is independently associated with left ventricular filling pressure in patients with type 2 diabetes mellitus

Kawata

Daimon

Miyazaki

et al. 2015

Cardiovasc Diabetol

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BackgroundLeft ventricular (LV) diastolic dysfunction is known as an early marker of myocardial alterations in patients with diabetes. Because microvascular disease has been regarded as an important cause of heart failure or diastolic dysfunction in diabetic patients, we tested the hypothesis that coronary flow reserve (CFR), which reflects coronary microvascular function, is associated with LV diastolic dysfunction in patients with type 2 diabetes.MethodsWe studied asymptomatic patients with type 2 diabetes but without overt heart failure. Transthoracic Doppler echocardiography was performed that included pulsed tissue Doppler of the mitral annulus and CFR of the left anterior descending artery (induced by adenosine 0.14 mg/kg/min). The ratio of mitral velocity to early diastolic velocity of the mitral annulus (E/e′) was used as a surrogate marker of diastolic function. We also evaluated renal function, lipid profile, parameters of glycemic control and other clinical characteristics to determine their association with E/e′. Patients with LV ejection fraction <50%, atrial fibrillation, valvular disease, regional wall motion abnormality, renal failure (serum creatinine >2.0 mg/dl) or type 1 diabetes were excluded. Patients with a CFR <2.0 were also excluded based on the suspicion of significant coronary artery stenosis.ResultsWe included 67 asymptomatic patients with type 2 diabetes and 14 non-diabetic controls in the final study population. In univariate analysis, age, presence of hypertension, LV mass index, estimated glomerular filtration rate and CFR were significantly associated with E/e′. Multivariate analysis indicated that both LV mass index and CFR were independently associated with E/e′. In contrast, there were no significant associations between parameters of glycemic control and E/e′.ConclusionsCFR was associated with LV filling pressure in patients with type 2 diabetes. This result suggests a possible link between coronary microvascular disease and LV diastolic function in these subjects.

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“…Previous studies have speculated on the influence of diastolic function on exercise capacity in HTx patients, and CFVR has been linked to dias- tolic function in patients with ischemic heart disease, 23 heart failure patients, 24 and healthy young individuals. 25 In our study, we found no significant correlation between peak CO and Doppler echocardiographic parameters of LV filling pattern.…”

Section: Discussionmentioning

confidence: 99%

Coronary Flow Reserve Predicts Longitudinal Myocardial Deformation Capacity in Heart‐Transplanted Patients

et al. 2015

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Coronary Flow Reserve Predicts Cardiopulmonary Fitness in Patients with Coronary Artery Disease Independently of Systolic and Diastolic Function

Cited by 11 publications

References 30 publications

Coronary microvascular dysfunction and myocardial contractile reserve in women with angina and no obstructive coronary artery disease

Coronary microvascular dysfunction and myocardial contractile reserve in women with angina and no obstructive coronary artery disease

Coronary microvascular function is independently associated with left ventricular filling pressure in patients with type 2 diabetes mellitus

Coronary Flow Reserve Predicts Longitudinal Myocardial Deformation Capacity in Heart‐Transplanted Patients

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