Coronary flow reserve is impaired in patients with adult growth hormone (GH) deficiency

Oflaz, Hüseyin; Şen, Fatma; Elıtok, Ali; Çımen, Arif Oğuzhan; Onur, Imran; Kaşıkçıoğlu, Erdem; Korkmaz, Semra; Demirtürk, Mustafa; Kutlutürk, Faruk; Pamukçu, Burak; Özbey, Neşe

doi:10.1111/j.1365-2265.2007.02767.x

Cited by 20 publications

(9 citation statements)

References 33 publications

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“…Treatment of patients with recombinant GH was reported to increase NO production, improve flow-mediated dilation, and decrease peripheral resistance (5,22,23,35,44). Coronary flow reserve is positively correlated with IGF-I levels (37), and cardiovascular disease risk is elevated among apparently healthy individuals who have serum IGF-I levels in the low-normal range (40). Recent data also suggest a protective role of IGF-I in cardiovascular stem cell physiology (28,49,51).…”

Section: Discussionmentioning

confidence: 99%

Endothelial function and vascular oxidative stress in long-lived GH/IGF-deficient Ames dwarf mice

Csiszár¹,

Labinskyy²,

Pérez³

et al. 2008

American Journal of Physiology-Heart and Circulatory Physiology

141

112

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Hypopituitary Ames dwarf mice have low circulating growth hormone (GH)/IGF-I levels, and they have extended longevity and exhibit many symptoms of delayed aging. To elucidate the vascular consequences of Ames dwarfism we compared endothelial O2(-) and H2O2 production, mitochondrial reactive oxygen species (ROS) generation, expression of antioxidant enzymes, and nitric oxide (NO) production in aortas of Ames dwarf and wild-type control mice. In Ames dwarf aortas endothelial O2(-) and H2O2 production and ROS generation by mitochondria were enhanced compared with those in vessels of wild-type mice. In Ames dwarf aortas there was a less abundant expression of Mn-SOD, Cu,Zn-SOD, glutathione peroxidase (GPx)-1, and endothelial nitric oxide synthase (eNOS). NO production and acetylcholine-induced relaxation were also decreased in aortas of Ames dwarf mice. In cultured wild-type mouse aortas and in human coronary arterial endothelial cells treatment with GH and IGF significantly reduced cellular O2(-) and H2O2 production and ROS generation by mitochondria and upregulated expression of Mn-SOD, Cu,Zn-SOD, GPx-1, and eNOS. Thus GH and IGF-I promote antioxidant phenotypic changes in the endothelial cells, whereas Ames dwarfism leads to vascular oxidative stress.

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Section: Discussionmentioning

confidence: 99%

Endothelial function and vascular oxidative stress in long-lived GH/IGF-deficient Ames dwarf mice

Csiszár¹,

Labinskyy²,

Pérez³

et al. 2008

American Journal of Physiology-Heart and Circulatory Physiology

141

112

View full text Add to dashboard Cite

show abstract

“…was not aware of the groups of subjects and is experienced in coronary flow measurements and evaluation of CFR in different clinical situation. Recently, the same Cardiology team has published the results of two other studies [27,28].…”

Section: Coronary Flow Measurementmentioning

confidence: 94%

Coronary flow reserve after l-thyroxine therapy in Hashimoto’s thyroiditis patients with subclinical and overt hypothyroidism

Oflaz

Kurt

Şen

et al. 2007

Endocr

Self Cite

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“…The local production of IGF1 in the CV system promotes paracrine signaling 88 and is associated with CV protection in humans and laboratory animals. 89–91 The systemic GH and IGF-1 levels decline progressively during aging 92 and, although controversial, GH and IGF-1 deficiency appear to be involved in the increased CVD risk and endothelial dysfunction. 93–95 The CR-mediated increase in cardiac-specific IGF-1 expression could contribute to the paracrine CV protection.…”

Section: Potential Interventions That Retard Cardiovascular Agingmentioning

confidence: 99%

Pharmacological Strategies to Retard Cardiovascular Aging

Alfaras

Germanio

Bernier

et al. 2016

Circulation Research

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Aging is the major risk factor for cardiovascular diseases (CVD), which are the leading cause of death in the United States. Traditionally, the effort to prevent CVD has been focused on addressing the conventional risk factors, including hypertension, hyperglycemia, hypercholesterolemia, and high circulating levels of triglycerides. However, recent preclinical studies have identified new approaches to combat CVD. Calorie restriction has been reproducibly shown to prolong lifespan in various experimental model animals. This has led to the development of calorie restriction mimetics and other pharmacological interventions capable to delay age-related diseases. In this review, we will address the mechanistic effects of aging per se on the cardiovascular system and focus on the pro-longevity benefits of various therapeutic strategies that support cardiovascular health.

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Coronary flow reserve is impaired in patients with adult growth hormone (GH) deficiency

Abstract: CFR is significantly lower in adults with GH deficiency than in controls. Direct correlation between CFR and IGF-1 concentrations suggests GH replacement could improve microvascular function and thereby could decrease cardiovascular morbidity and mortality in AGHD.

Cited by 20 publications

References 33 publications

Endothelial function and vascular oxidative stress in long-lived GH/IGF-deficient Ames dwarf mice

Endothelial function and vascular oxidative stress in long-lived GH/IGF-deficient Ames dwarf mice

Coronary flow reserve after l-thyroxine therapy in Hashimoto’s thyroiditis patients with subclinical and overt hypothyroidism

Pharmacological Strategies to Retard Cardiovascular Aging

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