Coronary Flow Reserve in Young Men With Familial Combined Hyperlipidemia

Pitkänen, Olli‐Pekka; Nuutila, Pirjo; Raitakari, Olli T.; Porkka, Kimmo; Iida, Hidehiro; Nuotio, Ilpo; Rönnemaa, Tapani; Viikari, Jorma; Taskinen, Marja‐Riitta; Ehnholm, Christian; Knuuti, Juhani

doi:10.1161/01.cir.99.13.1678

Cited by 89 publications

(46 citation statements)

References 52 publications

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“…Dugi et al (44) have shown that the extent of coronary atherosclerosis by angiography is inversely related to hepatic lipase levels and is higher in subjects with the LIPC promoter rare allele. A recent report indicated that the LIPC-480 T allele is associated with a decrease in coronary flow reserve (45), a measure of endothelial dysfunction (46). In addition, the LIPC promoter genotype predicts changes in coronary disease stenosis.…”

Section: Discussionmentioning

confidence: 99%

A Common Promoter Polymorphism in the Hepatic Lipase Gene (LIPC-480C>T) Is Associated With an Increase in Coronary Calcification in Type 1 Diabetes

et al. 2002

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Type 1 diabetes is associated with coronary heart disease (CHD) and coronary artery calcification (CAC), a measure of subclinical CHD. The hepatic lipase gene promoter polymorphism (LIPC-480C>T) is a common variant affecting lipid metabolism. This study examined the relation between the LIPC-480C>T and CAC in type 1 diabetes. In the type 1 diabetic patients studied, 56% had CAC >0 Agatston units (AU). These subjects had a longer duration of diabetes (26.2 ؎ 1.3 vs. 17.8 ؎ 1.4 years; P < 0.001), lower HDL cholesterol levels (55.7 ؎ 2.4 vs. 61.0 ؎ 2.5 mg/dl; P ‫؍‬ 0.05), higher triglyceride levels (101 ؎ 17.3 vs. 66 ؎ 7.6 mg/dl; P < 0.05), and higher diastolic blood pressure (79.7 ؎ 1.0 vs. 76.0 ؎ 1.4 mmHg; P < 0.05). The LIPC-480 T allele was more common in subjects with CAC (frequency ‫؍‬ 0.31 ؎ 0.05 vs. 0.14 ؎ 0.04; P ‫؍‬ 0.006). The proportion with CAC was 44% in LIPC-480CC subjects, 71% in heterozygotes, and 83% in LIPC-480TT subjects (P < 0.01). LIPC-480 T allele frequency increased as the amount of CAC increased (P ‫؍‬ 0.007). LIPC-480 genotype was independently associated with the CAC (odds ratio ‫؍‬ 2.90, 95% CI 1.22-6.92, P < 0.05) after adjusting for duration of diabetes, age, sex, diastolic blood pressure, HDL cholesterol, and triglyceride levels. In conclusion, the LIPC-480C>T polymorphism was associated with subclinical CHD in type 1 diabetes. This genetic variant may identify subjects in which early intervention to prevent CHD may be appropriate.

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Section: Discussionmentioning

confidence: 99%

A Common Promoter Polymorphism in the Hepatic Lipase Gene (LIPC-480C>T) Is Associated With an Increase in Coronary Calcification in Type 1 Diabetes

et al. 2002

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“…[1][2][3][4][5] The diagnosis is based on clinical criteria such as the presence of "multiple type hyperlipidemia," [2][3][4][5] increased concentrations of plasma apoB, and a positive family history of premature coronary heart disease (CHD). The genetic basis of FCHL has not been elucidated, although several groups have provided evidence suggesting that different genes are involved in the pathogenesis of this disorder.…”

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confidence: 99%

Delayed and Exaggerated Postprandial Complement Component 3 Response in Familial Combined Hyperlipidemia

Meijssen

Dijk

Verseyden

et al. 2002

ATVB

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“…These risk factors may impair MFR due to microangiopathy [46][47][48][49]. SPECT only provides a relative display of tracer uptake.…”

Section: Resultsmentioning

confidence: 99%

Reduced 123I-BMIPP uptake implies decreased myocardial flow reserve in patients with chronic stable angina

Kageyama

Morita

Katoh

et al. 2005

Eur J Nucl Med Mol Imaging

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Long-chain fatty acid (LCFA) is the main energy source for normal myocardium at rest. In ischemic myocardium, the main energy substrate shifts from LCFA to glucose. 123 I-BMIPP is a radiolabeled LCFA analogue. In chronic stable angina without previous infarction, we suppose that reduced 123 I-BMIPP uptake is related to the substrate shift in myocardium with decreased myocardial flow reserve (MFR). Conclusion: In chronic stable angina without previous infarction, reduced 123 I-BMIPP uptake implies decreased MFR.

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Coronary Flow Reserve in Young Men With Familial Combined Hyperlipidemia

Abstract: Background-Familial combined hyperlipidemia (FCHL) is a common hereditary disorder of lipoprotein metabolism estimated to cause 10% to 20% of premature coronary heart disease. We investigated whether functional abnormalities exist in coronary reactivity in asymptomatic patients with FCHL.

Cited by 89 publications

References 52 publications

A Common Promoter Polymorphism in the Hepatic Lipase Gene (LIPC-480C>T) Is Associated With an Increase in Coronary Calcification in Type 1 Diabetes

A Common Promoter Polymorphism in the Hepatic Lipase Gene (LIPC-480C>T) Is Associated With an Increase in Coronary Calcification in Type 1 Diabetes

Delayed and Exaggerated Postprandial Complement Component 3 Response in Familial Combined Hyperlipidemia

Reduced 123I-BMIPP uptake implies decreased myocardial flow reserve in patients with chronic stable angina

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Coronary Flow Reserve in Young Men With Familial Combined Hyperlipidemia

Abstract: Background-Familial combined hyperlipidemia (FCHL) is a common hereditary disorder of lipoprotein metabolism estimated to cause 10% to 20% of premature coronary heart disease. We investigated whether functional abnormalities exist in coronary reactivity in asymptomatic patients with FCHL.

Cited by 89 publications

References 52 publications

A Common Promoter Polymorphism in the Hepatic Lipase Gene (LIPC-480C&gt;T) Is Associated With an Increase in Coronary Calcification in Type 1 Diabetes

A Common Promoter Polymorphism in the Hepatic Lipase Gene (LIPC-480C&gt;T) Is Associated With an Increase in Coronary Calcification in Type 1 Diabetes

Delayed and Exaggerated Postprandial Complement Component 3 Response in Familial Combined Hyperlipidemia

Reduced 123I-BMIPP uptake implies decreased myocardial flow reserve in patients with chronic stable angina

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A Common Promoter Polymorphism in the Hepatic Lipase Gene (LIPC-480C>T) Is Associated With an Increase in Coronary Calcification in Type 1 Diabetes

A Common Promoter Polymorphism in the Hepatic Lipase Gene (LIPC-480C>T) Is Associated With an Increase in Coronary Calcification in Type 1 Diabetes