Coronary Endothelial Vasomotor Function and Vascular Remodeling in Heart Transplant Recipients Randomized for Tacrolimus or Cyclosporine Immunosuppression

Petrakopoulou, Paraskevi; Anthopoulou, Lydia; Muscholl, M.; Klauß, Volker; Scheidt, Wolfgang von; Überführ, P.; Meiser, Bruno; Reichart, Bruno; Weis, Michael

doi:10.1016/j.jacc.2005.10.073

Cited by 55 publications

(36 citation statements)

References 25 publications

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“…Cyclosporin A can increase LDL cholesterol levels and induce glucose intolerance, both of which can cause atherosclerosis (20). In addition, cyclosporin A has been shown to be associated with endotheliitis (21), increased circulating levels of endothelin 1, and coronary microvascular dysfunction (22). In the present study, 10 of the SLE patients (53%) were being treated with immunosuppressive drugs (5 with azathioprine and 5 with cyclosporin A) in combination with corticosteroids.…”

Section: Discussionmentioning

confidence: 68%

Altered coronary vasomotor function in young patients with systemic lupus erythematosus

Hirata

Kadirvelu

Kinjo

et al. 2007

Arthritis & Rheumatism

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Objective. Accelerated atherosclerosis is an important cause of morbidity and mortality in patients with systemic lupus erythematosus (SLE). Altered coronary microvascular function may act as a marker of changes that predispose to the development of significant coronary vascular disease. The purpose of this study was to compare coronary flow reserve (CFR) in a group of premenopausal women with SLE and a group of age-, sex-, and race-matched healthy control subjects.Methods. Coronary flow velocity in 18 premenopausal women with SLE (mean ؎ SD age 29.4 ؎ 5.9 years) and 19 matched healthy controls (mean ؎ SD age 28.2 ؎ 4.3 years) was assessed by transthoracic Doppler echocardiography after an overnight fast. The CFR was calculated as the ratio of hyperemic to baseline coronary blood flow velocity in the left anterior descending coronary artery. Hyperemia was induced by intravenous administration of adenosine triphosphate.Results. The mean ؎ SD duration of SLE was 8.2 ؎ 7.2 years (range 0.25-25 years), and the mean ؎ SD score on the Systemic Lupus Erythematosus Disease Activity Index was 11.0 ؎ 5.3 (range 4.0-21.0). Adequate recordings of flow velocity in the left anterior descending artery under both conditions were obtained using an ultrasound procedure in all study subjects. CFR was significantly lower in SLE patients as compared with control subjects (mean ؎ SD 3.4 ؎ 0.8 versus 4.5 ؎ 0.5; P < 0.0001).Conclusion. These findings provide evidence that coronary vasomotor function is impaired in patients with SLE and support the notion that many of these young patients have subclinical coronary artery disease.

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Section: Discussionmentioning

confidence: 68%

Altered coronary vasomotor function in young patients with systemic lupus erythematosus

Hirata

Kadirvelu

Kinjo

et al. 2007

Arthritis & Rheumatism

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“…In our population, the mean extension of the lesions assessed on IVUS was 14.039 mm, that is, more diffuse lesions than the focal pattern of the lesions associated with atherosclerosis. Studies have suggested that the site in which a concentric atherosclerotic lesion already exists differ from those where lesions associated with CAV occur [21][22][23][24][25][26][27][28] , which does not prevent the existence of both in the same vessel. This could justify the finding of extensive and proximal lesions in our population.…”

Section: Chart 1 -Stanford Classification Of Intracoronary Lesions Asmentioning

confidence: 98%

Avaliação da doença vascular do enxerto no transplante cardíaco: experiência de um centro brasileiro

Costa¹,

Wang²,

Susin³

et al. 2012

Arq. Bras. Cardiol.

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“…This effect could ultimately increase local cardiac inflammation and consequently facilitate the development of CAV. Although the function and effect of CNI-induced endothelial dysfunction in the pathogenesis of CAV is poorly understood, it has been demonstrated that both CsA and TAC induce vascular oxidative stress, increased endothelin-1 (ET-1) release, and contribute to the dysregulation of endothelial nitric oxide synthase (NOS) in the kidney [44,[62][63][64] . Indeed CNI-induced endothelial dysfunction includes the attenuation of the endothelium to release NO [65] , a physiologically relevant mechanism because decreased NO bioavailability is related to the production of reactive oxygen species (ROS) and thus oxidative stress [65] .…”

Section: Impact Of Immunosuppressive Regimens On Cavmentioning

confidence: 99%

Effects of Immunosuppressive agents on neutrophils inflammatory response in humans: An inflammatory perspective on coronary allograft vasculopathy

White

2016

Inflamm Cell Signal

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Cardiac transplantation (CTx) has improved survival in patients with advanced heart failure. Unfortunately, the conditional survival remains less than 15 years. The primary cause of mortality at 5 years following a CTx is the development of accelerated coronary atherosclerosis named coronary allograft vasculopathy (CAV). The neutrophils likely play an important role in this diffuse inflammatory process. Nevertheless, the contribution of the neutrophils on the pathogenesis of CAV is poorly understood. Regardless of their essential contribution for the prevention of graft rejection, immunosuppressive drugs (IDs) may have detrimental effects via some pro-inflammatory activities. This review presents the role of neutrophils on vascular inflammation and on the biologic effects of diverse immunosuppressive agents including mTOR inhibitors in the context of the pathophysiology of CAV. We investigated the impact of different IDs on the inflammatory responses of isolated human neutrophils harvested from healthy controls and herein, we reported on some novel characteristics of everolimus (EVE) on isolated neutrophils in comparison with other immunosuppressive agents. These biologic effects may contribute to their beneficial effects on the allograft vasculature and consequently on the prevention of CAV.

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Coronary Endothelial Vasomotor Function and Vascular Remodeling in Heart Transplant Recipients Randomized for Tacrolimus or Cyclosporine Immunosuppression

Cited by 55 publications

References 25 publications

Altered coronary vasomotor function in young patients with systemic lupus erythematosus

Altered coronary vasomotor function in young patients with systemic lupus erythematosus

Avaliação da doença vascular do enxerto no transplante cardíaco: experiência de um centro brasileiro

Effects of Immunosuppressive agents on neutrophils inflammatory response in humans: An inflammatory perspective on coronary allograft vasculopathy

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