Coronary artery aneurysm is an uncommon disease. It is defined as a coronary artery dilatation, which can be saccular or fusiform, and exceeds the diameter of the normal adjacent segment or the diameter of the patient's largest coronary vessel by 1.5-2 times.1,2 The natural history and prognosis of this disease remain obscure, and management continues to be a therapeutic dilemma, as most of the published recommendations are based on anecdotal experience. We report a giant left circumflex artery aneurysm, which we believe is the largest reported coronary aneurysm in the English literature.
Case ReportA 72-year-old man with no previous history of coronary artery disease presented to another hospital with a history of fever, chills, productive cough and shortness of breath for two months, progressing to hypercarbic respiratory failure on admission. He required intubation for two days, and was managed with intravenous antibiotics for the working diagnosis of pneumonia, based on clinical and radiological features. The patient was then transferred to our institution for further management. There was no history of smoking, diabetes or hypertension. He had a history of chronic bronchitis for 10 years, which had been treated intermittently with bronchodilators. He had no previous history of congestive heart failure.On physical examination, the patient was obese, afebrile, and in mild respiratory distress. His blood pressure was 100/60 mm Hg, and his heart rate was 80 beats/minute, which was regular. Jugular venous pressure was elevated at 8 cm above the sternal angle. Chest examination revealed bilateral coarse crepitations, and bronchial breath sounds were present over the left lower lung zone. Mitral and tricuspid valve regurgitation murmurs were present. Lower limb pitting edema was present up to the knees.On admission, the patient's arterial blood gas analysis showed a PO 2 of 60 mm Hg, PCO 2 of 106 mm Hg, and pH of 7.2 on room air. ECG revealed voltage criteria for left ventricular hypertrophy and nonspecific ST-segment changes. Cardiac enzymes (CK and troponin) were normal. Pulmonary function tests and a sleep study suggested central hypoventilation with no evidence of obstructive lung disease. Chest x-ray showed widened mediastinum, cardiomegaly, left lower lobe consolidation and small bilateral pleural effusions. CT scan of the thorax without contrast revealed a probable left ventricular aneurysm, and a very unusual dilated vessel with some calcification in its wall. The aneurysm was located along the superior aspect of the left atrium, and had the appearance of an aneurysmally dilated coronary artery, possibly the circumflex artery.The transthoracic echocardiography was a technically difficult study. Transesophageal echocardiography revealed moderate mitral regurgitation and a 6.6-cm vascular mass arising from the left circumflex artery. There was no evidence of a connection between the vascular mass and coronary sinus, pulmonary artery or any cardiac chambers. Left ventricular function was normal.Coronary angio...