Coronary computed tomography angiography with model-based iterative reconstruction using a radiation exposure similar to chest X-ray examination

Fuchs, Tobias A.; Stehli, Julia; Bull, Sacha; Dougoud, Svetlana; Clerc, Olivier; Herzog, Bernhard A.; Buechel, Ronny R.; Gaemperli, Oliver; Kaufmann, Philipp A.

doi:10.1093/eurheartj/ehu053

Cited by 85 publications

(43 citation statements)

References 25 publications

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“…One study found an ultra-low dose of 0.2 mSv in patients with a mean BMI of 25.2 kg m 22 using Model-Based Iterative Reconstruction, which is a modelbased IR algorithm. 22 All other studies investigated less advanced hybrid IR algorithms. Therefore with the development of model-based IR algorithms, the radiation dose is expected to decrease even further.…”

Section: Discussionmentioning

confidence: 99%

“…This explains why only two studies performed additional scans for research purposes in the same patients. 18,22 Another study tried to simulate a withinpatient comparison by using data from one detector of a dual source CT system. 20 This meta-analysis provides the possible dose reduction with IR as reported in the literature.…”

Section: Discussionmentioning

confidence: 99%

“…Different IR techniques were used namely Adaptive Statistical Iterative Reconstruction (ASIR; GE Healthcare, Milwaukee, WI, n 5 3), Sinogram-Affirmed Iterative Reconstruction (Siemens Healthcare, Erlangen, Germany, n 5 3), iDose (Philips Healthcare, Best, Netherlands, n 5 2), Iterative Reconstruction in Image Space (Siemens Healthcare, n 5 1) and Adaptive Iterative Dose Reduction (Toshiba Medical Systems Co Ltd., Otowara, Japan, n 5 1). One study compared Model-Based Iterative ReconstructionVeo (GE Healthcare) with ASIR, 22 since FBP was replaced by ASIR as the clinically implemented routine reconstruction method. CT systems used were Aquilion One™ (Toshiba Medical Systems Co Ltd., n 5 1), Brilliance iCT (Philips Healthcare, n 5 2), Discovery™ HD 750 (GE Healthcare, n 5 3) and Somatom® Definition Flash (Siemens Medical Systems, Forchheim, Germany, n 5 4).…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Most studies (n 5 7) used different study populations to compare FBP with IR; however, three studies compared different dose levels in the same patients. 18,20,22 This was achieved by using data from only one source of a dual-source CT scanner 20 or by making additional scans of the same patient. 18,22 Mean body mass index (BMI) varied between studies from 23.9 to 33.8 kg m 22 with heart rates of 57-74 beats per minute.…”

Section: Study Characteristicsmentioning

confidence: 99%

See 3 more Smart Citations

Dose reduction with iterative reconstruction for coronary CT angiography: a systematic review and meta-analysis

Harder

Willemink

Ruiter

et al. 2016

BJR

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Objective: To investigate the achievable radiation dose reduction for coronary CT angiography (CCTA) with iterative reconstruction (IR) in adults and the effects on image quality. Methods: PubMed and EMBASE were searched, and original articles concerning IR for CCTA in adults using prospective electrocardiogram triggering were included. Primary outcome was the effective dose using filtered back projection (FBP) and IR. Secondary outcome was the effect of IR on objective and subjective image quality. Results: The search yielded 1616 unique articles, of which 10 studies (1042 patients) were included. The pooled routine effective dose with FBP was 4.2 mSv [95% confidence interval (CI) 3.5-5.0]. A dose reduction of 48% to a pooled effective dose of 2.2 mSv (95% CI 1.3-3.1) using IR was reported. Noise, contrast-to-noise ratio and subjective image quality were equal or improved in all but one study, whereas signal-to-noise ratio was decreased in two studies with IR at reduced dose. Conclusion: IR allows for CCTA acquisition with an effective dose of 2.2 mSv with preserved objective and subjective image quality. INTRODUCTIONThe number of CT examinations has increased rapidly over the past decades leading to increased radiation exposure.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

See 2 more Smart Citations

Dose reduction with iterative reconstruction for coronary CT angiography: a systematic review and meta-analysis

Harder

Willemink

Ruiter

et al. 2016

BJR

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“…With the traditional reconstruction technique (filtered back projection [FBP]), radiation-dose reduction causes an increase in the image noise. However, iterative reconstruction (IR) techniques have been shown to reduce image noise and radiation dose and improve image quality [17,18]. Low tube voltage together with low-concentration contrast agent have been increasingly used in recent years, but most studies have focused on coronary arteries, head and neck, and pulmonary arteries [17,[19][20][21].…”

Section: Introductionmentioning

confidence: 99%

The feasibility of low-concentration contrast and low tube voltage in computed tomography perfusion imaging: an animal study

Pan

Song

et al. 2018

Bioscience Reports

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Aim: To investigate the feasibility of low-concentration contrast (270 mg/ml) together with low tube voltage (80 kV) and adaptive iterative dose reduction (AIDR)-3D reconstruction in liver computed tomography (CT) perfusion imaging. Method: A total of 15 healthy New Zealand rabbits received two CT scans each. The first scan (control) was acquired at 100 kV and 100 mA with iopromide (370 mg/ml), while the second scan (experimental) was acquired at 80 kV and 100 mA with iodixanol (270 mg/ml) 24 h after the first scan. The obtained images were reconstructed with filtered back projection (FBP) and AIDR-3D in the control and experimental groups respectively. The perfusion parameters (hepatic artery perfusion [HAP], portal vein perfusion [PVP], hepatic perfusion index [HPI], and total liver perfusion [TLP]) and image quality (image quality score, average CT value of abdomen aorta, signal-to-noise ratio [SNR], contrast-to-noise ratio [CNR], and figure of merit [FOM]) were compared using a paired t-test or Mann-Whitney U test between the two groups, when appropriate. The effective radiation dose and iodine intake were also recorded and compared. Results: With the exception of the FOM criteria, the image quality and perfusion parameters were not significantly different between the two groups. The effective radiation dose and iodine intake were 38.79% and 27.03% lower respectively, in the experimental group. Conclusion: Low-concentration contrast (iodixanol, 270 mg/ml) together with low tube voltage (80 kV) and AIDR-3D reconstruction help to reduce radiation dose and iodine intake without compromising perfusion parameters and image quality in liver CT perfusion imaging.

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Development of an organ‐specific insert phantom generated using a 3D printer for investigations of cardiac computed tomography protocols

Abdullah

McEntee

Reed

et al. 2018

J of Medical Radiation Sci

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IntroductionAn ideal organ‐specific insert phantom should be able to simulate the anatomical features with appropriate appearances in the resultant computed tomography (CT) images. This study investigated a 3D printing technology to develop a novel and cost‐effective cardiac insert phantom derived from volumetric CT image datasets of anthropomorphic chest phantom.MethodsCardiac insert volumes were segmented from CT image datasets, derived from an anthropomorphic chest phantom of Lungman N‐01 (Kyoto Kagaku, Japan). These segmented datasets were converted to a virtual 3D‐isosurface of heart‐shaped shell, while two other removable inserts were included using computer‐aided design (CAD) software program. This newly designed cardiac insert phantom was later printed by using a fused deposition modelling (FDM) process via a Creatbot DM Plus 3D printer. Then, several selected filling materials, such as contrast media, oil, water and jelly, were loaded into designated spaces in the 3D‐printed phantom. The 3D‐printed cardiac insert phantom was positioned within the anthropomorphic chest phantom and 30 repeated CT acquisitions performed using a multi‐detector scanner at 120‐kVp tube potential. Attenuation (Hounsfield Unit, HU) values were measured and compared to the image datasets of real‐patient and Catphan® 500 phantom.ResultsThe output of the 3D‐printed cardiac insert phantom was a solid acrylic plastic material, which was strong, light in weight and cost‐effective. HU values of the filling materials were comparable to the image datasets of real‐patient and Catphan® 500 phantom.ConclusionsA novel and cost‐effective cardiac insert phantom for anthropomorphic chest phantom was developed using volumetric CT image datasets with a 3D printer. Hence, this suggested the printing methodology could be applied to generate other phantoms for CT imaging studies.

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Coronary computed tomography angiography with model-based iterative reconstruction using a radiation exposure similar to chest X-ray examination

Cited by 85 publications

References 25 publications

Dose reduction with iterative reconstruction for coronary CT angiography: a systematic review and meta-analysis

Dose reduction with iterative reconstruction for coronary CT angiography: a systematic review and meta-analysis

The feasibility of low-concentration contrast and low tube voltage in computed tomography perfusion imaging: an animal study

Development of an organ‐specific insert phantom generated using a 3D printer for investigations of cardiac computed tomography protocols

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