Coronary computed tomography angiography evaluation of plaque morphology and its relationship to HDL and total cholesterol to HDL ratio

Manubolu, Venkat Sanjay; Verghese, Dhiran; Lakshmanan, Suvasini; Alalawi, Luay; Kinninger, April; Aldana-Bitar, Jairo; Calicchio, Francesca; Ahmad, Khadije; Ghanem, Ahmed; Javier, Denise Alison; Mangaoang, Czarina; Flores, Ferdinand; Dailing, Christopher; Roy, Sion K.; Budoff, Matthew J.

doi:10.1016/j.jacl.2022.06.003

Cited by 5 publications

(6 citation statements)

References 36 publications

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“…TC is an atherogenic marker, and HDL-C is an antiatherogenic lipid parameter. An increased number of studies now suggest that the ratio between them can jointly provide more information than an isolated indicator [ 35 , 36 ]. As of recently, the TC/HDL-C ratio is regarded as an essential risk factor and a more potent predictor of CVD incidence than TC, HDL-C, and LDL-C [ 36 , 37 ].…”

Section: Discussionmentioning

confidence: 99%

“…An increased number of studies now suggest that the ratio between them can jointly provide more information than an isolated indicator [ 35 , 36 ]. As of recently, the TC/HDL-C ratio is regarded as an essential risk factor and a more potent predictor of CVD incidence than TC, HDL-C, and LDL-C [ 36 , 37 ]. Studies demonstrated that a high TC/HDL-C ratio, especially more than 5, is considered to indicate an elevated risk of CVD, probably because of an imbalance in the proportion of cholesterol lipoproteins [ 36 , 37 ].…”

Section: Discussionmentioning

confidence: 99%

“…As of recently, the TC/HDL-C ratio is regarded as an essential risk factor and a more potent predictor of CVD incidence than TC, HDL-C, and LDL-C [ 36 , 37 ]. Studies demonstrated that a high TC/HDL-C ratio, especially more than 5, is considered to indicate an elevated risk of CVD, probably because of an imbalance in the proportion of cholesterol lipoproteins [ 36 , 37 ]. Cranberry consumption significantly reducing this ratio might suggest that cranberry potentially benefits lipid modulation.…”

Section: Discussionmentioning

confidence: 99%

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The Effects of Cranberry Consumption on Glycemic and Lipid Profiles in Humans: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Li,

Chen,

Xia

et al. 2024

Nutrients

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This study aims to update the evidence and clarify whether cranberry possesses lipid-lowering and hypoglycemic properties in humans. PubMed, Web of Science, and Scopus were searched to identify relevant articles published up to December 2023. In total, 3145 publications were reviewed and 16 of them were included for qualitative synthesis and meta-analysis. Stata 15.0 and Review Manager 5.4 were applied for statistical analyses. The results revealed a significant decrease in the total cholesterol to high-density lipoprotein cholesterol ratio (TC/HDL-C) (MD = −0.24; 95% CI: −0.45, −0.04; peffect = 0.02) and homeostasis model assessment of insulin resistance (HOMA-IR) (MD = −0.59; 95% CI: −1.05, −0.14; peffect = 0.01) with cranberry consumption. However, it did not influence total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglyceride (TG), fasting blood glucose (FBG), glycated hemoglobin (HbA1c), and fasting insulin. In subgroup analysis, cranberry consumption in dried form (capsules, powder, and tablets) was found to significantly decrease the fasting insulin level (three studies, one hundred sixty-five participants, MD = −2.16; 95% CI: −4.24, −0.07; peffect = 0.04), while intervention duration, health conditions, and dosage of polyphenols and anthocyanins had no impact on blood lipid and glycemic parameters. In summary, cranberry might have potential benefits in regulating lipid and glucose profiles.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The Effects of Cranberry Consumption on Glycemic and Lipid Profiles in Humans: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Li,

Chen,

Xia

et al. 2024

Nutrients

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“…Lastly, LDL/ HDL ratio was investigated as an atherogenic index to simultaneously assess the effects of HDL and LDL levels on patient outcomes, revealing a significant association. Recent studies also propose this index as a valuable predictor for cardiovascular risk assessments [ 37 – 40 ]. In a study on the Framingham data, Nam et al reported HDL/Total cholesterol and HDL/LDL as better predictors for cardiovascular outcomes compared to total cholesterol or LDL alone [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

Time-varying effect of postoperative cholesterol profile on long-term outcomes of isolated coronary artery bypass graft surgery

Ayati,

Akbari,

Shafiee

et al. 2023

Lipids Health Dis

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Background Controlling cholesterol levels is one of the primary goals of preventing atherosclerotic plaque progression in patients undergoing coronary artery bypass graft (CABG) surgery. This study aimed to investigate the impact of serum cholesterol profile at multiple time points following isolated CABG surgery on long-term patient outcomes. Method This retrospective cohort study was conducted on the admission and follow-up data of isolated CABG patients from the Tehran Heart Center registry between 2009 and 2016. The association of low-density lipoprotein (LDL), high-density lipoprotein (HDL), and their ratio as an atherogenic index with major adverse cardiac and cerebrovascular events (MACCE) and all-cause mortality were evaluated using time-varying survival analysis methods. Result A total of 18657 patients were included in this analysis. After adjusting for known confounding factors, no significant difference in all-cause mortality and MACCE was observed at different LDL levels. The incidence of acute coronary syndrome (ACS) in patients with LDL > 100 mg/dl and LDL < 50 mg/dl was significantly higher than in the control group (P-value = 0.004 and 0.04, respectively). The incidence of cerebrovascular accidents (CVA) at LDL > 100 mg/dl was also significantly higher compared to the control group (P -value = 0.033). Lower HDL levels were significantly associated with a higher MACCE (P -value < 0.001), all-cause mortality (P -value < 0.001), ACS (P -value = 0.00), and CVA (P -value = 0.014). The atherogenic index was also directly related to MACCE and all its components (all P-values < 0.001). Conclusion LDL/HDL ratio is suggested as a better marker for secondary prevention goals compared to LDL alone in patients undergoing CABG surgery.

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“…They also pointed out that a normal low-density lipoprotein cholesterol (LDL-C) level does not rule out other atherosclerotic abnormalities, such as a low HDL-C level, a high number of apolipoprotein B-containing particles, and small LDL-C particle size. They argued that the TC/HDL ratio could serve as an excellent marker as it provides a tremendous discriminatory ability for CAD [ 9 ]. Akin et al studied the applicability of CCTA in the detection of CAP burden and composition and their association with serum non-HDL-C levels, triglyceride (TG), and HDL-C ratio (TG/HDL-C) in young adults (<45 years old).…”

mentioning

confidence: 99%

The Roles of Coronary Computed Tomography Angiography in Characterizing Coronary Plaque: Screening, Treatment, and Prevention

Pour-Ghaz

Alkhatib

Isa

et al. 2023

JCDD

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Coronary computed tomography angiography evaluation of plaque morphology and its relationship to HDL and total cholesterol to HDL ratio

Cited by 5 publications

References 36 publications

The Effects of Cranberry Consumption on Glycemic and Lipid Profiles in Humans: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

The Effects of Cranberry Consumption on Glycemic and Lipid Profiles in Humans: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Time-varying effect of postoperative cholesterol profile on long-term outcomes of isolated coronary artery bypass graft surgery

The Roles of Coronary Computed Tomography Angiography in Characterizing Coronary Plaque: Screening, Treatment, and Prevention

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