Coronary calcifications and plaque characteristics in patients with end-stage renal disease

Abstract

ESRD is associated with diffuse atherosclerosis and calcific plaque morphology. Nonetheless, the association between the calcium score and atherosclerotic burden is not affected by the presence of ESRD.

Cardiac imaging for the assessment of patients being evaluated for kidney or liver transplantation

“…31 A few studies assessed the diagnostic accuracy of cardiac CT in comparison to invasive coronary angiography in patients with ESRD. [32][33][34][35][36][37] Budoff and co-workers showed that coronary calcium score has a reasonable discriminative capacity for coronary atherosclerosis in ESRD patients, with areas under the curve of 0.77 and 0.75 for detecting coronary stenoses C50% and C70%, respectively. 32 Rosario et al showed that Agatston's score C400 was associated with a higher number of significant stenoses by invasive coronary angiography.…”

“…[32][33][34][35][36][37] Budoff and co-workers showed that coronary calcium score has a reasonable discriminative capacity for coronary atherosclerosis in ESRD patients, with areas under the curve of 0.77 and 0.75 for detecting coronary stenoses C50% and C70%, respectively. 32 Rosario et al showed that Agatston's score C400 was associated with a higher number of significant stenoses by invasive coronary angiography. 34 Park et al reported that as compared to invasive coronary angiography, the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of coronary CT angiography for severe (C70%) coronary stenosis was 100%, 59%, 44%, and 100%, respectively.…”

Vascular Calcification on Plain Radiographs Is Related with the Severity of Lesions Detected by Coronary Angiography in Dialysis Patients

“…Coronary artery calcification (CAC) on CT is associated with coronary plaque accumulation (Jug et al 2013). Still, there are no reports comparing VC on plain radio-graphs to the degree of CAC or stenosis detected by CAG in patients undergoing dialysis.…”

Does hybrid imaging have a role in cardiac risk evaluation of the pre-renal transplant patient?

“…Patients with ESRD hence have a high burden of CAC compared to a non-CKD population and the association with ischemia is very weak as demonstrated before. 4,8 However, few studies have demonstrated a correlation of CACS with luminal stenosis and longterm outcomes even in the ESRD population. [8][9][10] Although EAT has been associated with atherosclerotic burden and cardiac outcomes, it provided very little (if any) incremental information for predicting abnormal perfusion in this study.…”

“…4,8 However, few studies have demonstrated a correlation of CACS with luminal stenosis and longterm outcomes even in the ESRD population. [8][9][10] Although EAT has been associated with atherosclerotic burden and cardiac outcomes, it provided very little (if any) incremental information for predicting abnormal perfusion in this study. 6 While both CACS and EAT information can be obtained by the same CT dataset, CACS is much easier to perform and most importantly there are established risk categories.…”