Coronary calcification in the diagnosis of coronary artery disease

Rifkin, Robert D.; Parisi, Alfred F.; Folland, Edward D.

doi:10.1016/0002-9149(79)90263-7

Cited by 161 publications

(59 citation statements)

References 22 publications

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“…The median volume of coronary calcification in the initial EBT scan was 155 mm 3 (range, 14 to 1849 mm 3 ). The median volume score in the second EBT scan, after an average interval of 421 days without lipid-lowering treatment, was 201 mm 3 (range, 19 to 2486 mm 3 ), and the median volume score in the third EBT scan, after an average interval of 370 days on treatment with cerivastatin, was 203 mm 3 , with a range from 15 to 2569 mm 3 . The median annualized absolute increase in calcified volume was 25 mm 3 (range, Ϫ79 to 506) without treatment compared with 11 mm 3 (range, Ϫ462 to 247) during treatment (Pϭ0.01).…”

Section: Coronary Calcificationmentioning

confidence: 99%

“…Three measures of coronary calcium were used in the study. Primary measure was a volume score, which was determined after isotropic interpolation to minimize partial volume effects 16,17 and yields the calcified volume within the coronary arteries in mm 3 ; secondary measures were the Agatston score, the calculation of which is based on the area and peak density of the calcified lesions, 7 and a mass score, which was obtained by multiplying the calcified volume by the volumetrically averaged CT density of the calcified lesions.…”

Section: Electron Beam Tomographymentioning

confidence: 99%

“…C oronary calcifications are associated with atherosclerotic coronary artery plaque, [1][2][3] and the amount of coronary calcifications has been shown to correlate with the overall coronary plaque burden. 4 -6 The presence and extent of coronary calcifications can be assessed noninvasively using fast CT techniques, such as electron beam tomography (EBT) 7,8 or multislice CT. 9,10 Several investigations have shown that the quantity of coronary calcium measured by CT progresses over time.…”

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confidence: 99%

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Influence of Lipid-Lowering Therapy on the Progression of Coronary Artery Calcification

et al. 2002

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Background-Coronary calcification measured by fast computed tomography techniques is a surrogate marker of coronary atherosclerotic plaque burden. In a cohort study, we prospectively investigated whether lipid-lowering therapy with a cholesterol synthesis enzyme inhibitor reduces the progression of coronary calcification. Methods and Results-In 66 patients with coronary calcifications in electron beam tomography (EBT), LDL cholesterol Ͼ130 mg/dL, and no lipid-lowering treatment, the EBT scan was repeated after a mean interval of 14 months and treatment with cerivastatin was initiated (0.3 mg/d). After 12 months of treatment, a third EBT scan was performed. Coronary calcifications were quantified using a volumetric score. Cerivastatin therapy lowered the mean LDL cholesterol level from 164Ϯ30 to 107Ϯ21 mg/dL. The median calcified volume was 155 mm 3 (range, 15 to 1849) at baseline, 201 mm 3 (19 to 2486) after 14 months without treatment, and 203 mm 3 (15 to 2569) after 12 months of cerivastatin treatment. The median annualized absolute increase in coronary calcium was 25 mm 3 during the untreated versus 11 mm 3 during the treatment period (Pϭ0.01). The median annual relative increase in coronary calcium was 25% during the untreated versus 8.8% during the treatment period (PϽ0.0001). In 32 patients with an LDL cholesterol level Ͻ100 mg/dL under treatment, the median relative change was 27% during the untreated versus Ϫ3.4% during the treatment period (Pϭ0.0001). Conclusions-Treatment with the cholesterol synthesis enzyme inhibitor cerivastatin significantly reduces coronary calcium progression in patients with LDL cholesterol Ͼ130 mg/dL.

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Section: Coronary Calcificationmentioning

confidence: 99%

Section: Electron Beam Tomographymentioning

confidence: 99%

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confidence: 99%

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Influence of Lipid-Lowering Therapy on the Progression of Coronary Artery Calcification

et al. 2002

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“…[5][6][7][8] The American Heart Association recently reviewed the data validating electron beam computed tomography (EBCT) and its ability to detect and quantify coronary calcification noninvasively. 9 A direct relationship has been established between coronary artery calcium as measured by EBCT and both histologic 10,11 and in vivo intravascular ultrasound 12,13 measures of atherosclerotic plaque on a heart-by-heart, vessel-by-vessel, and segment-by-segment basis.…”

Section: Mayo Clin Proc 1999;74:243-252mentioning

confidence: 99%

Electron Beam Computed Tomographic Coronary Calcium Scanning: A Review and Guidelines for Use in Asymptomatic Persons

Rumberger

Brundage²,

Rader

et al. 1999

Mayo Clinic Proceedings

742

449

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“…Coronary artery calcification (CAC) is the accumulation of calcification in atherosclerotic plaques, and is an indicator of coronary atherosclerosis [3][4][5][6][7]. It is also a subclinical predictor of future coronary events [8,9].…”

Section: Introductionmentioning

confidence: 99%

The relationship between the existence of angiographic coronary artery calcification and the severity of coronary artery disease

Küçükdurmaz¹,

Sezen²,

Ulaş³

et al. 2012

pwki

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The relationship between the existence of angiographic coronary artery calcification and the severity of coronary artery disease Związek między zwapnieniami tętnic wieńcowych w angiografii a zaawansowaniem choroby wieńcowej Z Ze ek ke er ri iy ya a K Ku uc cu uk kd du ur rm ma az z 1 1 , , Y Yu us su uf f S Se ez ze en n 2 2 , , T Tu ur rg ga ay y U Ul la as s A b s t r a c t B Ba ac ck kg gr ro ou un nd d: : Coronary artery calcification (CAC) is a predictor of coronary artery disease (CAD) and closely related to major adverse cardiac events. The Gensini score is a scoring system to determine the severity and extent of coronary atherosclerosis.A Ai im m: : We aimed to investigate the relationship between CAC and both the extent and severity of CAD. M Ma at te er ri ia al l a an nd d m me et th ho od ds s: : Coronary artery calcification was identified by visual examination during fluoroscopic examination. The study population was divided into two groups, according to the presence or absence of CAC. The CAC(+) group consisted of 126 patients (45 women, 81 men), the CAC(-) group 156 patients (58 women, 98 men). Gensini scores were calculated from the results of coronary angiography.R Re es su ul lt ts s: : We identified CAC more frequently in type 2 diabetes mellitus patients, with no gender differences. Other risk factors for CAD -including age, hypertension, smoking, body mass index, waist circumference, and systolic blood pressure -were not significantly different between the CAC(+) and CAC(-) groups. Serum levels of triglyceride and very low density lipoprotein (VLDL) cholesterol were significantly lower in the CAC(+) group, and diastolic blood pressure levels and type 2 diabetes mellitus (DM) frequency were higher. By logistic regression, an independent relationship was identified between the Gensini score and CAC.C Co on nc cl lu us si io on ns s: : Coronary calcification seems to be more prevalent in type 2 DM patients than in the normal population. The Gensini score, that is, the extent and severity of coronary artery disease, appears to be independently related to CAC, an issue that warrants further investigation to allow for future clinical applications.

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Coronary calcification in the diagnosis of coronary artery disease

Cited by 161 publications

References 22 publications

Influence of Lipid-Lowering Therapy on the Progression of Coronary Artery Calcification

Influence of Lipid-Lowering Therapy on the Progression of Coronary Artery Calcification

Electron Beam Computed Tomographic Coronary Calcium Scanning: A Review and Guidelines for Use in Asymptomatic Persons

The relationship between the existence of angiographic coronary artery calcification and the severity of coronary artery disease

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