Coronary Bypass Surgery in Kawasaki Disease in a Four-Year-Old Patient: Case Report

Abstract

Kawasaki disease is an acute vasculitis syndrome of unknown etiology that mainly affects small and medium-sized arteries, particularly the coronary arteries. This disease is rarely seen in infants and young people in Turkey. In this short report, we present a four-year-old patient who has Kawasaki disease associated with coronary artery aneurysm and underwent coronary bypass grafting.

The Role of Complement in the Pathogenesis of Artery Aneurysms

“…Early demonstration that there is a negative correlation between serum immunoglobin level and complement activity in the Kawasaki disease patients with aneurysm provides the clinical evidence to link the potential role of complement to the formation of artery aneurysms (Miyata et al, 1984). Kawasaki disease (KD), is an autoimmune disease that manifests as a systemic necrotizing medium-sized vessel vasculitis and is largely seen in children under five years of age (Ozkan et al, 2007). It affects many organ systems, mainly those including the blood vessels, skin, mucous membranes and lymph nodes; however, its most serious effect is on the heart, where it can cause severe coronary artery aneurysms in untreated children.…”