Coronary Blood Flow and Myocardial Metabolism in Hypothermia

Edwards, W. Sterling; Tuluy, S.; Reber, W E; Siegel, A.; Bing, Richard J.

doi:10.1097/00000658-195403000-00003

Cited by 82 publications

(19 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…per cent sigma of 1.81 and a probability of 0.15). This is in line with the previous observation that changes in myocardial oxygen consumption are brought about by variations in coronary flow and not by alterations in myocardial oxygen extraction (31,32 In-cm co I I I I and, therefore, myocardial oxygen usage decreased significantly during oligemic shock (mean fall in oxygen usage of 7.75 cc. with a sigma of 3.08 and a probability of 0.005).…”

Section: Resultssupporting

confidence: 92%

“…It had been shown in previous studies that the changes in coronary blood flow and not the myocardial oxygen exrtion are responsible for alterations in myocardial-oxygen consumption (31,32). In most organs, a reduction of blood flow is at least partially compensated for by increased oxygen extraction.…”

Section: Metabolic Changes During Normovolemic Shockmentioning

confidence: 97%

“…This is in contrast to the effect of a reduction in body temperature (hypothermia). There, metabolic disturbances do not develop because the reduction in body temperature lessens oxygen demands and supply in the same proportion (31).…”

Section: Metabolic Changes During Normovolemic Shockmentioning

confidence: 99%

See 2 more Smart Citations

Studies on Myocardial Metabolism. III. Coronary Blood Flow, Myocardial Oxygen Consumption and Carbohydrate Metabolism in Experimental Hemorrhagic Shock12

Edwards¹,

Siegel²,

Bing³

1954

J. Clin. Invest.

View full text Add to dashboard Cite

Section: Resultssupporting

confidence: 92%

Section: Metabolic Changes During Normovolemic Shockmentioning

confidence: 97%

See 1 more Smart Citation

Studies on Myocardial Metabolism. III. Coronary Blood Flow, Myocardial Oxygen Consumption and Carbohydrate Metabolism in Experimental Hemorrhagic Shock12

Edwards¹,

Siegel²,

Bing³

1954

J. Clin. Invest.

View full text Add to dashboard Cite

“…This is in line with the observations in the current experiment. Hypothermia has also been demonstrated to reduce the metabolic demand of the cells [22,35,36,23]. In the current experiment, hypothermia treatment resulted in a significantly higher mixed venous saturation, pH and base excess.…”

Section: Discussionmentioning

confidence: 46%

Hypothermia in cardiogenic shock reduces systemic t-PA release

Pals

Götberg

et al. 2010

J Thromb Thrombolysis

View full text Add to dashboard Cite

“…The exact mechanism through which therapeutic hypothermia exerts it's tissue protective effect is not known, but it is thought to reduce the metabolic demand of the cells [31][32][33][34]. However, reduced oxygen demand does not fully explain the positive effects of hypothermia and several additive effects have been suggested [35].…”

Section: Discussionmentioning

confidence: 99%

Mild hypothermia markedly reduces ischemia related coronary t-PA release

Pals

Götberg

Olivecrona

et al. 2009

J Thromb Thrombolysis

View full text Add to dashboard Cite

"Mild hypothermia markedly reduces ischemia related coronary t-PA release." Journal of thrombosis and thrombolysis, 2009 Jun 5 http://dx.doi.org/10.1007/s11239-009-0350-2Access to the published version may require journal subscription.Published with permission from: Springer Methods: Sixteen 25-30 kg pigs were anesthetized and a temperature of 37°C was established using an intravascular cooling/warming catheter. The pigs were then randomized to hypothermia (34°C) or control (37°C). A doppler flow wire was placed distal to a percutaneous coronary intervention balloon positioned immediately distal to the first diagonal branch of the left anterior descending artery (LAD). The LAD was then occluded for ten minutes in all pigs. Coronary blood flow and t-PA was measured before, during and after ischemia/reperfusion. t-PA was measured in peripheral arterial blood and locally in the venous blood from the coronary sinus. Net t-PA release over the coronary bed was calculated by subtraction of arterial values from coronary sinus values. An estimate of differences in total t-PA release was calculated by multiplying net t-PA release with the relative increase in flow compared to baseline, measured in relative units consisting of ((ng/ml -ng/ml) x (cm/s / cm/s)).Results: There was no observed difference in t-PA levels in peripheral arterial samples. As shown previously, net t-PA release increased during reperfusion. Hypothermia significantly inhibited the increase in t-PA release during reperfusion (peak value 9.44±4.34 ng/ml vs 0.79±0.45 ng/ml, p=0.02). The effect was even more prominent when an estimation of total t-PA release was performed with mean peak value in the control group 26 fold higher than in the hypothermia group (69.74±33.86 units vs 2.62±1.10 units, p=0.01). Conclusion:Mild hypothermia markedly reduces ischemia related coronary tissue plasminogen activator release. The reduction of t-PA release may contribute to the cardioprotective effect of hypothermia.

show abstract

Coronary Blood Flow and Myocardial Metabolism in Hypothermia

Cited by 82 publications

References 11 publications

Studies on Myocardial Metabolism. III. Coronary Blood Flow, Myocardial Oxygen Consumption and Carbohydrate Metabolism in Experimental Hemorrhagic Shock12

Studies on Myocardial Metabolism. III. Coronary Blood Flow, Myocardial Oxygen Consumption and Carbohydrate Metabolism in Experimental Hemorrhagic Shock12

Hypothermia in cardiogenic shock reduces systemic t-PA release

Mild hypothermia markedly reduces ischemia related coronary t-PA release

Contact Info

Product

Resources

About