Coronary atherosclerotic burden in patients with infection by CagA-positive strains of Helicobacter pylori

Abstract

These results support the association between CagA-positive H. pylori infection and coronary atherosclerotic burden. Further studies are needed to better elucidate the mechanism by which CagA-positive strains may promote atherosclerosis.

Extragastric Manifestations of Helicobacter pylori Infection

“…They clearly showed that the seroprevalence of CagA‐positive strains was significantly higher in patients with acute MI and UA than controls (86.7, 91.7, and 58.3%, respectively). Another study conducted by our group in Rome on the role of CagA positivity in patients undergoing coronary angiography showed that the titer of anti‐CagA antibodies was significantly higher in patients with coronary atherosclerosis than in subjects with normal coronary arteries [2]. Interestingly, a positive correlation between CagA antibody titer and the extent score of the atherosclerotic disease was also found.…”

Extragastric Manifestations of Helicobacter pylori Infection

“…Among the extraintestinal manifestations of H. pylori infection, ischemic heart disease (IHD) still ranks among the first positions [1,2]. Al-Ghamdi et al [3] in a recent study reported a higher prevalence of antiChlamydia pneumoniae and anti-H. pylori IgG in patients with acute coronary heart disease (CAD) compared to controls.…”

Early prognosis of unstable angina patients with positive Helicobacter pylori IgG values

“…This has been proved by a study by Espinola-Klein et al, who showed significant association between infectious burden and the extent of atherosclerosis and also that in individuals with advanced atherosclerosis, the future risk of death is increased by the number of infectious IJBR (2013) 04 (03) www.ssjournals.com pathogens. Study by Niccoli et al also support the association between CagA-positive H. pylori infection and coronary atherosclerotic burden 12 . The higher infectious burden in individuals with coronary artery disease has also been supported by an Iranian study 13 .…”