Coronary atherosclerosis and chemotherapy: From bench to bedside

Abstract

Cardiovascular disease, particularly coronary artery disease, is the leading cause of death in humans worldwide. Coronary heart disease caused by chemotherapy affects the prognosis and survival of patients with tumors. The most effective chemotherapeutic drugs for cancer include proteasome inhibitors, tyrosine kinase inhibitors, immune checkpoint inhibitors, 5-fluorouracil, and anthracyclines. Animal models and clinical trials have consistently shown that chemotherapy is closely associated with coronary events and can cause serious adverse cardiovascular events. Adverse cardiovascular events after chemotherapy can affect the clinical outcome, treatment, and prognosis of patients with tumors. In recent years, with the development of new chemotherapeutic drugs, new discoveries have been made about the effects of drugs used for chemotherapy on cardiovascular disease and its related mechanisms, such as inflammation. This review article summarizes the effects of chemotherapeutic drugs on coronary artery disease and its related mechanisms to guide efforts in reducing cardiovascular adverse events during tumor chemotherapy, preventing the development of coronary heart disease, and designing new prevention and treatment strategies for cardiotoxicity caused by clinical tumor chemotherapy.

Identification of Immuno-Inflammation-Related Biomarkers for Acute Myocardial Infarction Based on Bioinformatics

“…5-fluorouracil is widely used in the treatment of malignancies and has been reported to have side effects on coronary arteries, which is probably attributed to systemic endothelial cell damage and procoagulant state activation. 97 Afatinib has been associated with the development of HF while treating lung cancer. 98 Use of these two drugs in AMI still needs to be further studied.…”

Hemodynamical behavior analysis of anemic, diabetic, and healthy blood flow in the carotid artery

“…They also observed that hypertension increases stenosis severity in the carotid artery [18,19]. This increases the angular phase difference between wall shear stress and circumferential stress waves at the stenosis throat, as well as the negative wall shear stress and oscillatory shear in the post-stenosis region [35,36,39].…”

Unlocking potential biomarkers bridging coronary atherosclerosis and pyrimidine metabolism-associated genes through an integrated bioinformatics and machine learning approach

“…Disrupted metabolic pathways are a hallmark of disease pathology. Advances in metabolic research have shed light on the interplay between metabolic processes and disease development, identifying potential therapeutic targets and biomarkers [5]. Moreover, metabolism is critical in modulating immune responses and inflammatory conditions.…”