Coronary Atheroma Regression and Plaque Characteristics Assessed by Grayscale and Radiofrequency Intravascular Ultrasound After Aerobic Exercise

Madssen, Erik; Moholdt, Trine; Videm, Vibeke; Wisløff, Ulrik; Hegbom, Knut; Wiseth, Rune

doi:10.1016/j.amjcard.2014.08.012

Cited by 56 publications

(66 citation statements)

References 29 publications

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“…HIT is shown to have a positive effect on CAV progression in mice (61) and also in patients who have experienced MI (62). We found the same trend in maintenance HTx recipients after the HIT intervention in the TEX 1 study (46), but the positive effects were not sustained in the long-term as shown in the TEX 2 study (paper 2).…”

Section: Hit and The Effect On Cavsupporting

confidence: 59%

“…More recently, a Scandinavian multicenter RCT (The Schedule-study) has shown that early everolimus initiation with calcineurin inhibitor withdrawal reduce the progression of CAV in de-novo HTx recipients (59,60). The effect of non-medical prevention strategies has also been studied by IVUS, such as HIT interventions, and have shown less progression of arthrosclerosis in mice (61) and in patients with myocardial infarction (MI) (62), and we have also demonstrated less development of CAV the first year after initiation of HIT in HTx recipients (46).…”

Section: Cardiac Allograft Vasculopathy (Cav)mentioning

confidence: 97%

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Peak oxygen uptake and self‐reported physical health are strong predictors of long‐term survival after heart transplantation

Yardley

Havik

Grov

et al. 2015

Clinical Transplantation

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Background Peak oxygen uptake (VO2peak) is known as the gold standard measure of cardiopulmonary fitness. We therefore hypothesized that measures of physical health would predict long‐term survival in heart transplant recipients (HTx). Methods This retrospective study investigated survival in two HTx populations; the cardiopulmonary exercise test (CPET) cohort comprised 178 HTx patients who completed a VO2peak test during their annual follow‐up (1990–2003), and the SF‐36 cohort comprised 133 patients who completed a quality of life questionnaire, SF‐36v1 (1998–2000). Results Mean (SD) age in the CPET cohort was 52 (12) yr and 54 (11) yr in the SF‐36 cohort. Mean observation time was, respectively, 11 and 10 yr. Mean (SD) VO2peak was 19.6 (5.3) mL/kg/min, and median (IR) physical function (PF) score was 90 (30). VO2peak and PF scores were both significant predictors in univariate Cox regression. Multiple Cox regression analyses adjusted for other potential predictors showed that VO2peak, age, and cardiac allograft vasculopathy (CAV) were the most important predictors in the CPET cohort, whereas age, PF score, smoking, and CAV were the most important predictors in the SF‐36 cohort. In Kaplan–Meier analysis, VO2peak and PF scores above the median value were related to significant longer survival time. Conclusion Peak oxygen uptake and self‐reported physical health are strong predictors for long‐term survival in HTx recipients. VO2peak is a crucial measurement and should be more frequently used after HTx.

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Section: Hit and The Effect On Cavsupporting

confidence: 59%

Section: Cardiac Allograft Vasculopathy (Cav)mentioning

confidence: 97%

Peak oxygen uptake and self‐reported physical health are strong predictors of long‐term survival after heart transplantation

Yardley

Havik

Grov

et al. 2015

Clinical Transplantation

View full text Add to dashboard Cite

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“…A regression of stenosis could not be shown in any group. Even if all patients were analyzed irrespective of group assignment, the 10.7% decline in plaque burden over time was not statistically significant ( P =0.06) 99. Because of a missing control group, this trend might have been confounded by observational bias or a change in medical therapy, especially in statin treatment.…”

Section: Mechanism 3: Regression Of Coronary Stenosismentioning

confidence: 92%

Physical Activity in the Prevention and Treatment of Coronary Artery Disease

Winzer

Woitek

Linke

2018

JAHA

171

120

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“…In a retrospective analysis in humans, higher physical fitness levels were associated with high fibrous volume and thick fibrous cap thickness of coronary plaques (324). Recently, 12-weeks of exercise training in patients with CAD decreased the necrotic plaque core (190). These effects of exercise training on conduit artery wall characteristics may have important clinical implications in terms of both plaque stabilisation, the evolution of plaque volume and rupture.…”

Section: Green Et Al Exercise Hemodynamics and Vascular Adaptationmentioning

confidence: 99%

Vascular Adaptation to Exercise in Humans: Role of Hemodynamic Stimuli

Green

Hopman

Padilla

et al. 2017

Physiological Reviews

505

570

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On the 400 th anniversary of Harvey's Lumleian lectures, this review focusses on the impact of physical exercise on "hemodynamic" forces associated with the movement of blood through arteries in humans and the functional and structural adaptations that result from repeated episodic exposure to such stimuli. The late 20 th century discovery that endothelial cells modify arterial tone via paracrine transduction, provoked studies exploring the direct mechanical effects of blood flow and pressure on vascular function and adaptation in vivo. In this review, we address the impact of distinct hemodynamic signals that occur in response to exercise, the inter-relationships between these signals, the nature of the adaptive responses that manifest under different physiological conditions and the implications for human health.Exercise modifies blood flow, luminal shear stress, arterial pressure and tangential wall stress, all of which can transduce changes in arterial function, diameter and wall thickness.There are important clinical implications of the adaptation that occurs as a consequence of repeated hemodynamic stimulation associated with exercise training in humans, including impacts on atherosclerotic risk in conduit arteries, the control of blood pressure in resistance vessels, oxygen delivery and diffusion, and microvascular health. Exercise training studies have demonstrated that direct hemodynamic impacts on the health of the artery wall contribute substantially to the well-established decrease in cardiovascular risk attributed to physical activity.

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Coronary Atheroma Regression and Plaque Characteristics Assessed by Grayscale and Radiofrequency Intravascular Ultrasound After Aerobic Exercise

Cited by 56 publications

References 29 publications

Peak oxygen uptake and self‐reported physical health are strong predictors of long‐term survival after heart transplantation

Peak oxygen uptake and self‐reported physical health are strong predictors of long‐term survival after heart transplantation

Physical Activity in the Prevention and Treatment of Coronary Artery Disease

Vascular Adaptation to Exercise in Humans: Role of Hemodynamic Stimuli

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