Coronary artery vasospasm and cardiogenic shock as the initial presentation for eosinophilic granulomatosis with polyangiitis

Bitar, Abdallah Y.; Thompson, Caleb D.; Tan, Christina; Allem, Kavitta; Khachatrian, A S; P, Weis; Garg, Vikram K; Srivastava, Ajay

doi:10.1016/j.jccase.2015.12.001

Cited by 5 publications

(3 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a case series reported by Wong et al in 2008, among 19 cases of CSA due to eosinophilia, 5 were diagnosed as EGPA (Churg-Strauss syndrome) (4). To our knowledge, there were another eight cases of EGPA complicated with CSA reported from 2009-2021 (5)(6)(7)(8)(9)(10)(11)(12). All cases were reported to be negative for ANCA.…”

Section: Discussionmentioning

confidence: 89%

Successful Treatment with Mepolizumab for Coronary Spastic Angina Associated with Eosinophilic Granulomatosis with Polyangiitis

Takigawa,

Fujiwara,

Tabuchi

et al. 2023

Intern. Med.

View full text Add to dashboard Cite

A 46-year-old man with a history of bronchial asthma and chronic sinusitis presented to our hospital with chest pain. We suspected angina evoked by epicardial coronary spasm and performed an ergonovine provocation test to diagnose coronary spastic angina (CSA). The patient also met the diagnostic criteria for eosinophilic granulomatosis with polyangiitis (EGPA) and was treated with 60 mg prednisolone (PSL) for EGPAassociated CSA. After PSL administration, eosinophils decreased, and angina attacks disappeared. However, when PSL was tapered to 12.5 mg, chest pain recurred. We administered mepolizumab subcutaneously and chest pain disappeared. Additional mepolizumab may be effective for EGPA with CSA.

show abstract

Section: Discussionmentioning

confidence: 89%

Successful Treatment with Mepolizumab for Coronary Spastic Angina Associated with Eosinophilic Granulomatosis with Polyangiitis

Takigawa,

Fujiwara,

Tabuchi

et al. 2023

Intern. Med.

View full text Add to dashboard Cite

show abstract

“…Cardiac complications may vary from subtle with minimal clinical significance to an extent to cause life threatening events as happened in this patient [ 6 ]. Potentially serious cardiac complications include endocarditis, myocarditis, acute pericarditis, coronary vasculitis, myocardial ischemia, conductance disturbance, arrhythmia, valvular dysfunction, eosinophilic pericardial effusion, and sudden death.…”

Section: Discussionmentioning

confidence: 99%

“…Potentially serious cardiac complications include endocarditis, myocarditis, acute pericarditis, coronary vasculitis, myocardial ischemia, conductance disturbance, arrhythmia, valvular dysfunction, eosinophilic pericardial effusion, and sudden death. They may even progress to left ventricular dysfunction, constrictive pericarditis, and myocardial fibrosis as a late sequelae [ 5 , 6 ].…”

Section: Discussionmentioning

confidence: 99%

Cardiogenic Shock: An Unusual Initial Presentation of Churg-Strauss Syndrome

Apirami

Pratheepan

Kumanan

et al. 2018

Case Reports in Rheumatology

View full text Add to dashboard Cite

Churg-Strauss syndrome (CSS) is a rare autoimmune condition, characterized by necrotizing extravascular eosinophil rich granulomatous inflammation of the tissues and disseminated small-medium sized vessel vasculitis in a patient with bronchial asthma and tissue eosinophilia. Though pulmonary involvement is the predominant feature of CSS, extra pulmonary involvement, in particular, cardiac involvement, denotes an adverse outcome. Here we report a 50-year-old female who presented with cardiogenic shock due to an acute coronary event as the initial manifestation of CSS. A subsequent coronary angiogram revealed normal epicardial coronaries. She was a patient with bronchial asthma and developed vasculitic rash, bilateral sensory motor polyneuropathy, and migratory peripheral lung field shadows in the background of peripheral eosinophilia during the course of the illness. She was diagnosed as having CSS based on ACR criteria and aggressively treated with immunosuppressants according to her Five-Factor Score and has shown prompt response to therapy. This case report adds to the literature another rare initial presentation of CSS to the existing array of its clinical manifestations.

show abstract

Cardiogenic shock in autoimmune rheumatologic diseases: an insight on etiologies, management, and treatment outcomes

et al. 2020

View full text Add to dashboard Cite

Coronary artery vasospasm and cardiogenic shock as the initial presentation for eosinophilic granulomatosis with polyangiitis

Cited by 5 publications

References 9 publications

Successful Treatment with Mepolizumab for Coronary Spastic Angina Associated with Eosinophilic Granulomatosis with Polyangiitis

Successful Treatment with Mepolizumab for Coronary Spastic Angina Associated with Eosinophilic Granulomatosis with Polyangiitis

Cardiogenic Shock: An Unusual Initial Presentation of Churg-Strauss Syndrome

Cardiogenic shock in autoimmune rheumatologic diseases: an insight on etiologies, management, and treatment outcomes

Contact Info

Product

Resources

About