Coronary Artery Dynamics In Vivo

Ding, Zhaohua; Zhu, Hongqing; Friedman, Morton H.

doi:10.1114/1.1467925

Cited by 56 publications

(55 citation statements)

References 24 publications

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“…Conversely, there is also a study indicating that the effect of arterial wall deformation on arterial flow can be insignificant [18]. Experimental data showed that wall motion of non-stenosed coronary arteries was approximately less than 8.4% of the vessel diameter (5.4±2% [19] and 2% [20] in terms of strain, 8.4% in diameter [21]). However, studies on stenosis and plaque structure [22][23][24][25] have demonstrated the importance of FSI in stenosed arteries.…”

Section: Introductionmentioning

confidence: 90%

Fluid–structure interaction analysis of a patient‐specific right coronary artery with physiological velocity and pressure waveforms

Torii

Wood

Hadjiloizou

et al. 2009

Commun. Numer. Meth. Engng.

122

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SUMMARYCoupled fluid-structure interaction (FSI) analysis of the human right coronary artery (RCA) has been carried out to investigate the effects of wall compliance on coronary hemodynamics. A 3-D model of a stenosed RCA was reconstructed based on multislice computerized tomography images. A velocity waveform in the proximal RCA and a pressure waveform in the distal RCA of a patient with a severe stenosis were acquired with a catheter delivered wire probe and applied as boundary conditions. The arterial wall was modeled as a Mooney-Rivlin hyperelastic material. The predicted maximum wall displacement (3.85 mm) was comparable with the vessel diameter (∼ 4mm), but the diameter variation was much smaller, 0.134 mm at the stenosis and 0.486 mm in the distal region. Comparison of the computational results between the FSI and rigid-wall models showed that the instantaneous wall shear stress (WSS) distributions were affected by diameter variation in the arterial wall; increasing systolic blood pressure dilated the vessel and consequently lowered WSS, whereas the opposite occurred when pressure started to decrease. However, the effects of wall compliance on time-averaged WSS (TAWSS) and oscillatory shear index (OSI) were insignificant (4.5 and 2.7% difference in maximum TAWSS and OSI, respectively).

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Section: Introductionmentioning

confidence: 90%

Fluid–structure interaction analysis of a patient‐specific right coronary artery with physiological velocity and pressure waveforms

Torii

Wood

Hadjiloizou

et al. 2009

Commun. Numer. Meth. Engng.

122

View full text Add to dashboard Cite

show abstract

“…8,16 In the first frame of one of the projections, several (8 in the present work) points along the axis of the vessel segment are marked and paired with corresponding points in the other projection using the calibration cube images. Each point pair represents the projections of the same 3D point.…”

Section: Dynamic Geometry Parametersmentioning

confidence: 99%

“…The torsion result is consistent with an earlier observation that vessel segments in the neighborhood of angiographically identified atherosclerotic lesions exhibited significantly higher torsion than angiographically normal portions of the same vessels. 8 Maximum (MaT) and mean (MeT) wall thickness are most strongly influenced by the torsion variables dsp and dst. Both thickness variables are larger where the torsion measures are greater, and both decrease with increases in dsp and dst, as described earlier.…”

Section: Zhu and Friedman Coronary Artery Dynamics And Wall Thicknessmentioning

confidence: 99%

Relationship Between the Dynamic Geometry and Wall Thickness of a Human Coronary Artery

Zhu

Friedman

2003

ATVB

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Objective-It is widely recognized that hemodynamic and wall mechanical forces are involved in the initiation and development of atherosclerosis. In the coronary vasculature, these forces are likely mediated by arterial dynamics and geometry. This research examines the hypothesis that coronary artery motion and geometry affect the local predisposition to disease, presumably through their influence on the stresses at and in the artery wall. Methods and Results-The dynamics of a human right coronary artery and the variation of wall thickness along its length were characterized from biplane cineangiograms and intravascular ultrasound records, respectively. The dynamic geometry parameters were distance along the vessel, cyclic displacement, axial strain, curvature, and torsion. Multiple regression analyses using principal components show that (1) no single dynamic geometry parameter has a dominant influence on wall thickness, (2) Key Words: coronary arteries Ⅲ dynamic geometry Ⅲ wall thickness Ⅲ biplane angiography Ⅲ intravascular ultrasound A lthough several cardiovascular risk factors, including hypercholesterolemia, hypertension, smoking, and diabetes, have been associated with coronary heart disease (CHD), 1,2 it is conventional knowledge among investigators in atherosclerosis that these factors can explain no more than half of the variability in the occurrence of atherosclerotic lesions or CHD. [3][4][5] This situation suggests that there are additional risk factors that predispose to arterial disease. Friedman and colleagues 6 -8 have proposed that variations in arterial geometry, including the dynamic characteristics of the coronary arteries, can contribute to some of the unexplained variation in cardiovascular risk. This idea is based on the abundant and increasing evidence that hemodynamics and vascular wall stresses play an important role in the initiation and development of atherosclerosis. 9,10 The fluid dynamic environment at the arterial wall depends on the geometry and motion of the channel through which the flow is passing, and geometries that promote an adverse hemodynamic milieu could constitute additional risk factors for disease. Similarly, the motion of the coronary arteries during the cardiac cycle can lead to cyclic stresses in the wall that may prompt an atherosclerotic response.Most research seeking associations between coronary artery geometry and vessel pathology has been based on autopsy hearts. [11][12][13][14] This is in part because of a lack of relevant data for the in vivo situation. Biplane cineangiography and intravascular ultrasound (IVUS) are 2 powerful modalities for assessing this relationship in vivo. While the former modality makes it possible to accurately reconstruct the time-dependent 3D course of the coronary vessels on the beating heart, the latter provides the necessary in vivo vessel wall morphology. In this study, we demonstrate the use of these diagnostic techniques to evaluate the relationship between the dynamic geometry and morphometry of a human right coronary ar...

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“…The behaviour of an RCA and LAD over two cardiac cycles has been recorded by Ding et al , Ding et al, 2002 , Weydahl et al, 2001, Zeng et al, 2003, in particular wall shear stresses, while less is known about the influence of such motions on arterial stresses post-stenting.…”

Section: Introductionmentioning

confidence: 99%

Stresses in peripheral arteries following stent placement: a finite element analysis

Early

Lally

Prendergast

et al. 2009

Computer Methods in Biomechanics and Biomedical Engineering

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The success of stents to restore blood flow in atherosclerotic peripheral arteries is low relative to coronary arteries. It has been shown that joint flexion induces a mechanical environment that makes stent placement in these arteries highly incompatible, and damage and destruction of stents has been recorded. However, the effect of this environment on the stresses in the arteries is unknown. It is hypothesised that the stresses induced in arteries as a result of this mechanical environment could be sufficient to explain the relatively low success rates. To investigate this hypothesis, a finite element model of the stent-artery interaction was developed. Following stent expansion, bending was simulated by applying a displacement boundary condition to the artery. It is found that high stresses occur at the proximal/distal ends of the stent. As stress and vascular injury are hypothesised to cause restenosis, the results presented here suggest that the mechanical environment of peripheral arteries could be the predominant cause of high restenosis rates.

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Coronary Artery Dynamics In Vivo

Cited by 56 publications

References 24 publications

Fluid–structure interaction analysis of a patient‐specific right coronary artery with physiological velocity and pressure waveforms

Fluid–structure interaction analysis of a patient‐specific right coronary artery with physiological velocity and pressure waveforms

Relationship Between the Dynamic Geometry and Wall Thickness of a Human Coronary Artery

Stresses in peripheral arteries following stent placement: a finite element analysis

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