Coronary Artery Diseases

Abstract

In 2000-2005 he was working as lead researcher in hightech companies SQUID AG and MagScan GmbX (Germany). Currently, he is senior staff scientist in the field of medical cybernetics at International Research and Training Center for ITandS of NAS of Ukraine. He combines clinical work with research, focusing on advanced methods for analysis (including pattern recognition) of electrocardiogram , magnetocardiogram , heart rate variability and implementation of such approaches in clinical routine. His research in these areas has been presented at international congresses (ESC, AHA, ACC and many others) and has appeared in academic journals such as PACE, Clinical Cardiology, Annals of Noninvasive Electrocardiology, European Heart Journal, Biophysics etc. He is the author of the book (together with L. Fainzilberg) , devoted to analysis of PrefaceThis book has "wide geography" both literally and figuratively. First of all, this book brings together contributions from around the world, both from post-industrial countries and developing world. This is natural, because coronary artery disease is becoming pandemic worldwide. CAD is the single most frequent cause of death in developed countries, causes about 1 in every 5 deaths.Mortality from cardiovascular disease is predicted to reach 23.4 million in 2030. Moreover, in the developing world, cardiovascular disease tends to affect people at a younger age and thus could negatively affect the workforce and economic productivity. The morbidity, mortality, and socioeconomic importance of CAD make its diagnosis and management fundamental for all practicing physicians. On another hand, the book widely represents "geography" of CAD itself, i.e. many various aspects of its pathophysiology, epidemiology, diagnosis, treatment are touched in this book.Pathophysiologic mechanisms of CAD are well studied in general, but there are some details to be clarified. Oxidative stress is considered as one of important pathogenetic components of the atherosclerosis course, studies of its effect onto the atherosclerotic plaque formation and progression are still lasted. Section "Coronary artery disease: pathophysiology and epidemiology" includes the review "Coronary Artery Disease and Oxidative Stress"concerning this problem.Another chapter in this Section is an epidemiological research demonstrating capabilities of the modern genetic risk factors in improvement of the ability to predict incident CAD beyond that afforded by traditional non genetic risk factors.Section "Coronary artery disease: diagnostic features" begins with the chapter "Magnetocardiography in Unshielded Setting: Heart Electrical Image based on 2-D and 3-D Data in Comparison with Perfusion Image Based on PET Results", devoted to the promising technique of investigation of the cardiac electrical generatormagnetocardiography (MCG). Comparison is drawn of the cardiac imaging on the base of current density distribution maps, obtained by MCG and PET images. Two other articles of this Section are devoted to the different issues of the mo...