Coronary Artery Disease: Why We should Consider the Y Chromosome

Molina, Elsa; Clarence, Elyse M; Ahmady, Farah; Chew, Guat Siew; Charchar, Fadi J.

doi:10.1016/j.hlc.2015.12.100

Cited by 19 publications

(16 citation statements)

References 61 publications

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“…Changes in plasma testosterone levels were found to positively correlate with MAP, as seen in male and female intact and gonadectomized rats and in gonadectomized female rats receiving exogenous testosterone treatment. The increase in MAP in ovariectomized female rats of both strains following exogenous testosterone treatment strengthened the argument that testosterone increases the blood pressure as this model eliminates the effect of male sex chromosome, which has been implicated in causing higher blood pressure in males compared with females (13,14,32). Our findings were supported by the results of Reckelhoff et al (36) who demonstrated an increase in MAP in testosterone-treated female SHR rats.…”

Section: Discussionsupporting

confidence: 86%

Influence of testosterone on mean arterial pressure: A physiological study in male and female normotensive WKY and hypertensive SHR rats

Loh

Salleh

2017

Physiol. Int.

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Introduction Testosterone plays an important role in the blood pressure regulation. However, information with regard to the effect of this hormone on blood pressure in normotensive and hypertensive conditions is limited. Therefore, in this study, the relationship between plasma testosterone level and mean arterial pressure (MAP) was investigated under these conditions. Methods Normotensive Wistar-Kyoto (WKY) and hypertensive Spontaneous Hypertensive (SHR) male and female rats were gonadectomized with female rats treated with testosterone. Estrous cycle stages of intact female rats of both strains were identified by vaginal smear. Pressure in the carotid artery of anesthetized rats was measured via direct cannulation technique. The blood was withdrawn for plasma testosterone level measurement by enzyme-linked immunosorbent assay. Results Treatment of ovariectomized female WKY and SHR rats with testosterone for 6-week duration has resulted in MAP to increase (P < 0.05). In male WKY and SHR rats, MAP and plasma testosterone levels decreased by orchidectomy (P < 0.05). No significant differences in MAP and plasma testosterone levels were observed in intact female WKY and SHR rats between stages of the estrous cycle. Conclusions The effects seen in testosterone-treated ovariectomized female rats and in orchidectomized male rats suggested that testosterone could play an important role in causing the blood pressure to increase.

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Section: Discussionsupporting

confidence: 86%

Influence of testosterone on mean arterial pressure: A physiological study in male and female normotensive WKY and hypertensive SHR rats

Loh

Salleh

2017

Physiol. Int.

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“…Therefore, how these SRY -negative 47,XXY females have a slightly different phenotype remains unknown and requires further evaluations. Recent studies have indicated that coronary artery disease [Molina et al, 2016] and autoimmunity [Case et al, 2013] may be involved with the Y chromosome and thus may concern men's health; these findings might represent signs of possible additional functions of the Y chromosome.…”

Section: Discussionmentioning

confidence: 99%

A 47,XXY Pregnant Woman without the <b><i>SRY</i></b> Gene

Hu¹,

Liu²,

Ma³

et al. 2019

Sex Dev

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Individuals with a 47,XXY karyotype usually present with a male phenotype due to the additional Y chromosome. In this paper, we describe a 47,XXY female who was pregnant with a fetus of the same karyotype based on chromosome analysis of amniotic fluid cells. Further analysis of her Y chromosome indicated that the additional Y chromosome contains no SRY gene on the short arm but carries the azoospermia factor region on the long arm, including azoospermia factor a, b and c (AZFa, AZFb, AZFc). This region may influence her female phenotype. Fertile females with a 47,XXY karyotype and loss of SRY are extremely rare. This paper is the first report of a 47,XXY pregnant woman with a normal phenotype and may enrich our knowledge on 47,XXY individuals.

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“…CAD involves damage from plaque accumulating on the arterial wall. The buildup of plaque progressively hardens and narrows blood vessels, a process known as atherosclerosis [45]. MI, a severe complication of CAD, is commonly defined as a cardiomyocyte death due to a prolonged ischemia and increase in serum cardiac markers, such as troponin [46].…”

Section: Discussionmentioning

confidence: 99%