Coronary artery disease is associated with higher epicardial Retinol‐binding protein 4 (RBP4) and lower glucose transporter (GLUT) 4 levels in epicardial and subcutaneous adipose tissue

Salgado-Somoza, Antonio; Teijeira-Fernández, Elvis; Rubio, José António; Couso, Elena; González-Juanatey, José Ramón; Eiras, Sonia

doi:10.1111/j.1365-2265.2011.04140.x

Cited by 51 publications

(38 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These derangements appear to be related to infiltration of the adipose tissue by macrophages and upregulation of bioactive molecules that could exert their effects through paracrine and vasocrine mechanisms [48,49]. Consistent with this finding, epicardial fat of subjects affected by coronary artery disease was found to be more abundant and to exhibit greater oxidative stress and inflammatory burden than SC fat [50][51][52]. In addition, in obese patients EAT amount was associated with increased left ventricular mass, right ventricular cavity size, atrial enlargement and diastolic dysfunction [53][54][55].…”

Section: Ectopic Fat Depots and Their Local Effectssupporting

confidence: 61%

Fat and Lipid Partitioning: Phenotyping Beyond BMI

2017

DEMD

View full text Add to dashboard Cite

The world-wide obesity epidemic, predisposing towards several chronic diseases, not only poses a major public health issue, but also has a negative impact on individual' life expectancy and quality. These two dimensions may need distinct diagnostic and preventive approaches. Indeed, whether BMI and total adiposity are positively correlated with cardiometabolic disease risk at the population level, adipose tissue regional distribution and lipid storage in ectopic tissues define the obesity phenotype and, thus, better predict the risk of developing obesity complications at the individual level.Indeed, together with the more extensively studied intraabdominal adipose tissue, smaller ectopic visceral depots have, in the recent years, gained increasing attention for their putative role in mediating the local detrimental effects of obesity. It has also been increasingly appreciated that intracellular lipid accumulation in non-adipose tissues leads to pathological responses and impaired insulin signaling. This narrative review focuses on the phenotypic differences between different adipose depots that link their depotspecific biology to obesity specific complications.

show abstract

Section: Ectopic Fat Depots and Their Local Effectssupporting

confidence: 61%

Fat and Lipid Partitioning: Phenotyping Beyond BMI

2017

DEMD

View full text Add to dashboard Cite

show abstract

“…Furthermore, the expression levels of glucose transporter-4 (GLUT4) are lower, whereas those of renitolbinding protein 4 (RBP4) are higher in EAT from CAD compared to non-CAD subjects [46], suggesting that EAT may partly be responsible for local insulin resistance and altered glucose and lipid profile, which, in turn, can promote atherogenic changes in coronary vessels.…”

Section: The Clinical Relevance Of Eat In Coronary Artery Diseasementioning

confidence: 99%

“…Finally, a higher oxidative stress, which also actively participates in the development and progression of atherosclerotic plaques, has been reported in EAT from CAD patients, as shown by higher levels of reactive oxygen species and lower levels of catalase (an antioxidant enzyme) compared to subcutaneous fat [46]. Recent studies have also reported that the increased oxidative stress characterizing EAT of CAD patients is capable of promoting transdifferentiation of brown to white adipocytes [47] and that an increase in 'brown' features of EAT could predict the stability of coronary atheromas in humans [48].…”

Section: The Clinical Relevance Of Eat In Coronary Artery Diseasementioning

confidence: 99%

Epicardial adipose tissue: at the heart of the obesity complications

Guglielmi

Sbraccia

2017

Acta Diabetol

View full text Add to dashboard Cite

In recent years, the anatomic and functional contiguity of epicardial adipose tissue (EAT) to myocardium and coronary arteries has gained increasing interest for its potential pathogenetic role in obesity-related cardiac diseases. Besides its known and attributed biochemical cardioprotective properties, it is becoming evident that, in metabolic disease states, EAT-secreted bioactive molecules may play an important role in the pathogenesis of coronary artery disease and cardiac arrhythmias. EAT-derived inflammatory cytokines and reactive oxidative species may, indeed, play a part in the development of a local proatherogenic milieu by paracrine and vasocrine mechanisms of interaction. In addition, initial clinical and in vitro studies have pointed out that EAT could be a determinant of the substrate of atrial fibrillation by contributing to the structural and electrical remodeling of myocardium. This article reviews the current state of knowledge on the association of EAT with cardiac dysfunction and the potential factors mediating the cross talk between this fat depot and the underlying cardiac structures.

show abstract

“…Furthermore, EAT from HF patients expresses lower levels of fatty acid-binding protein 4 (FABP4) (72) and fat-mobilizing genes (35). In addition, loss of diacylglycerol O-acyltransferase 1 (DGAT1) activity in heart muscle reduces gene expression involved in free FA uptake, such as CD36, reducing toxic lipid accumulation in the heart (47).…”

mentioning

confidence: 99%

Glucose uptake and lipid metabolism are impaired in epicardial adipose tissue from heart failure patients with or without diabetes

Burgeiro

Fuhrmann

Cherian

et al. 2016

American Journal of Physiology-Endocrinology and Metabolism

View full text Add to dashboard Cite

Glucose uptake and lipid metabolism are impaired in epicardial adipose tissue from heart failure patients with or without diabetes. Am J Physiol Endocrinol Metab 310: E550 -E564, 2016. First published January 26, 2016 doi:10.1152/ajpendo.00384.2015.-Type 2 diabetes mellitus is a complex metabolic disease, and cardiovascular disease is a leading complication of diabetes. Epicardial adipose tissue surrounding the heart displays biochemical, thermogenic, and cardioprotective properties. However, the metabolic cross-talk between epicardial fat and the myocardium is largely unknown. This study sought to understand epicardial adipose tissue metabolism from heart failure patients with or without diabetes. We aimed to unravel possible differences in glucose and lipid metabolism between human epicardial and subcutaneous adipocytes and elucidate the potential underlying mechanisms involved in heart failure. Insulin-stimulated [14 C]glucose uptake and isoproterenol-stimulated lipolysis were measured in isolated epicardial and subcutaneous adipocytes. The expression of genes involved in glucose and lipid metabolism was analyzed by reverse transcription-polymerase chain reaction in adipocytes. In addition, epicardial and subcutaneous fatty acid composition was analyzed by high-resolution proton nuclear magnetic resonance spectroscopy. The difference between basal and insulin conditions in glucose uptake was significantly decreased (P ϭ 0.006) in epicardial compared with subcutaneous adipocytes. Moreover, a significant (P Ͻ 0.001) decrease in the isoproterenol-stimulated lipolysis was also observed when the two fat depots were compared, and it was strongly correlated with lipolysis, lipid storage, and inflammation-related gene expression. Moreover, the fatty acid composition of these tissues was significantly altered by diabetes. These results emphasize potential metabolic differences between both fat depots in the presence of heart failure and highlight epicardial fat as a possible therapeutic target in situ in the cardiac microenvironment.

show abstract

Coronary artery disease is associated with higher epicardial Retinol‐binding protein 4 (RBP4) and lower glucose transporter (GLUT) 4 levels in epicardial and subcutaneous adipose tissue

Abstract: Retinol-binding protein 4 levels behave differently in EAT and SAT with respect to CAD. However, both adipose tissues have lower GLUT4 levels in patients with CAD. These findings suggest a differential regulation of RBP4 production in EAT and SAT that may be influenced by local factors.

Cited by 51 publications

References 36 publications

Fat and Lipid Partitioning: Phenotyping Beyond BMI

Fat and Lipid Partitioning: Phenotyping Beyond BMI

Epicardial adipose tissue: at the heart of the obesity complications

Glucose uptake and lipid metabolism are impaired in epicardial adipose tissue from heart failure patients with or without diabetes

Contact Info

Product

Resources

About