Coronary artery disease is associated with the ratio of apolipoprotein A-I/B and serum concentration of apolipoprotein B, but not with paraoxonase enzyme activity in Iranian subjects

Rahmani, Maziar; Raiszadeh, Farbod; Allahverdian, Sima; Kiaii, Shahryar; Navab, Mohamad; Azizi, Fereidoun

doi:10.1016/s0021-9150(01)00715-8

Cited by 44 publications

(33 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, studies on measurement of serum PON enzyme activity as a marker of CAD have revealed controversial findings with varying degrees of association in different communities; these findings have suggested that expression of these factors is under genetic control [19,20]. …”

Section: Discussionmentioning

confidence: 99%

“…Regardless of its genetic or environmental determinants, a low PON1 activity was reported to be associated with endothelial dysfunction expressed as brachial artery flow-mediated vasodilation (FMV) in patients with symptomatic peripheral artery disease [35], while BAd and male gender were shown as independent predictors of brachial FMV in a multivariate analysis [35]. Moreover, interethnic variability in PON1 polymorphism along with unimodal distribution of PON1 activity in non-Europid populations was suggested to cause the lack of a significant difference in PON1 activity between diabetic CAD patients and non-CAD controls in a previous study [20]. .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Relation of Paraoxonase 1 Activity with Biochemical Variables, Brachial Artery Intima-Media Thickness in Patients with Diabetes with or without Obesity

Karakaya

Özdemir²,

Mert³

et al. 2018

Obes Facts

View full text Add to dashboard Cite

Aim: The sodium-sparing effect of insulin leads to increase in total sodium pool of the body which is a chronic stimulus for atrial natriuretic peptide (ANP). In our study we aimed to determine the relationship between ANP and microvascular complications of diabetes. Methods: 60 patients, 30-70 years old, with the diagnosis of type 2 diabetes mellitus (DM) are enrolled into the study. Patients with a chronic disease other than DM are excluded. Blood samples for routine biochemical tests are taken after at least 12 h fasting at 8-9 am. Blood samples for glucose and insulin levels are taken 2 h after a standard meal. Blood tubes with EDTA are used for ANP levels. The microvascular complications of the patients are evaluated. Results: 32 of the patients had microvascular complications. Age, BMI, waist and hip circumferences, and ANP levels were significantly higher in the group with microvascular complications. There were no significant differences in waist-to-hip ratio, blood glucose, HbA1c, fasting insulin, postprandial insulin, fasting HOMA, postprandial HOMA as well as sodium, potassium, magnesium, calcium and lipid levels between the two groups. When the relationship between ANP and obesity, retinopathy, neuropathy, nephropathy, diabetes time, HbA1c, or sex are evaluated separately, the only significant parameters related to ANP were obesity and retinopathy. Conclusion: In our study we have found that there was a significant relationship between ANP levels and microvascular complications of diabetes. Future studies are needed to show if ANP is the stimulus of microvascular complication development/progression or only an epiphenomenon.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Relation of Paraoxonase 1 Activity with Biochemical Variables, Brachial Artery Intima-Media Thickness in Patients with Diabetes with or without Obesity

Karakaya

Özdemir²,

Mert³

et al. 2018

Obes Facts

View full text Add to dashboard Cite

show abstract

“…Cross-sectional [27] and case-control studies [28,29] have not consistently shown an association between paraoxonase activity and various end-points of CHD, although two case-control studies yielded a positive association [26,30]. However, the smaller numbers of subjects involved in these studies may account for the contradictory results.…”

Section: Paraoxonase Activity In Cases and Controlsmentioning

confidence: 95%

Paraoxonase activity and coronary heart disease risk in healthy middle-aged males: The PRIME study

et al. 2008

View full text Add to dashboard Cite

Objective: Classic coronary heart disease (CHD) risk factors fail to explain the large gradient in CHD incidence between Northern Ireland and France. The Prospective Epidemiological Study of Myocardial Infarction (PRIME) study, a multicentre prospective study of 10,593 middle-aged males, investigated novel risk factors in these populations. We tested the hypotheses that (1) higher paraoxonase activity is associated with decreased CHD risk and (2) PON55 LL genotype is associated with increased CHD risk. Methods: Paraoxonase activity was measured in 299 men who had developed CHD at 5-year follow-up and in 576 matched controls. DNA was available from 247 cases and 433 controls for genotyping for the PON55 polymorphism. Results: There was no significant difference in paraoxonase activity between cases and controls (geometric means 73.8 and 74.2 U/l; p = 0.81). There was no significant difference in CHD risk between fifths of paraoxonase activity either before (p = 0.55) or after adjustment for classical risk factors (p = 0.58).There was no significant association between genotype and CHD risk; relative to the LL genotype, the OR (95% CI) for the LM and MM genotypes were 0.92 (0.66-1.29) and 0.83 (0.50-1.36), respectively. The frequency of the L allele in cases (66.6%) and controls (64.5%) did not differ significantly, p = 0.45. Conclusions: These findings suggest that neither paraoxonase activity nor PON55 genotype is associated with CHD risk in males in the PRIME study.

show abstract

“…S1; Supplementary Data are available online at www.liebertonline .com/dna). Finally, a total of 47 eligible association studies were identified (Ayub et al, 1999;Hasselwander et al, 1999;Karakaya et al, 1999;Itahara et al, 2000;James et al, 2000;Liu et al, 2000;Sentí et al, 2001;Bai et al, 2002;Ferré et al, 2002;Luo et al, 2002Luo et al, , 2008Rahmani et al, 2002;Suehiro et al, 2002;Azarsiz et al, 2003;Mackness et al, 2003Mackness et al, , 2006Qian et al, 2003;Wang et al, 2003;Lacinski et al, 2004;Gö çmen et al, 2004Gö çmen et al, , 2008Li et al, 2004;Rodríguez-Esparragó n et al, 2005;Su et al, 2005Su et al, , 2006Blatter Garin et al, 2006;Chi et al, 2006;Kerkeni et al, 2006;Kotur-Stevuljevic et al, 2006;Qi et al, 2006;Sarkar et al, 2006;Sharma et al, 2007;Singh et al, 2007;Yang et al, 2007;Bhattacharyya et al, 2008;Gamboa et al, 2008;Lu et al, 2008;Sentü rk et al, 2008;Troughton et al, 2008;…”

Section: Characteristics Of Studiesmentioning

confidence: 99%

Quantitative Assessment of the Influence of Paraoxonase 1 Activity and Coronary Heart Disease Risk

Wang

Lang²,

Cui³

et al. 2012

DNA and Cell Biology

View full text Add to dashboard Cite

Human paraoxonase 1 (PON1) is a calcium-dependent high-density lipoprotein associated ester hydrolase that has attracted considerable attention as a candidate factor for coronary heart disease (CHD) based on its function as a key factor in lipoprotein catabolism pathways. This meta-analysis aimed to clarify the inconsistency of published studies and to establish a comprehensive picture of the relationship between PON1 activity and CHD susceptibility. A systematic search was performed from PubMed, Web of Science, EMBASE, and CNKI databases. Ratio of means (RoM) between case and control and 95% confidence intervals (CIs) were calculated using a random-effects model. The source of heterogeneity was explored by subgroup analysis and meta-regression. We identified 47 eligible studies including a total of 9853 CHD cases and 11,408 controls. The pooled analysis showed that CHD patients had a 19% lower PON1 activity than did the controls (RoM=0.81; 95% CI: 0.74-0.89, p<10(-5)). In the subgroup analyses by CHD end points, a similar effect size was observed with coronary stenosis and myocardial infarction subgroups, with corresponding RoM of 0.81 (95% CI: 0.73-0.89, p<10(-4)) and 0.83 (95% CI: 0.74-0.93, p=0.001), respectively. Decreased PON1 activity associated with CHD risk was observed in almost all subgroup analysis according to ethnicity, sample size, study design, mean age of cases, source, and type of control. Decreased PON1 activity may act as a risk factor for the development of CHD. Progressive decrease in serum PON1 activity may exist for an individual with severe disease. However, larger studies using a prospective approach are needed to confirm our results.

show abstract

Coronary artery disease is associated with the ratio of apolipoprotein A-I/B and serum concentration of apolipoprotein B, but not with paraoxonase enzyme activity in Iranian subjects

Cited by 44 publications

References 50 publications

Relation of Paraoxonase 1 Activity with Biochemical Variables, Brachial Artery Intima-Media Thickness in Patients with Diabetes with or without Obesity

Relation of Paraoxonase 1 Activity with Biochemical Variables, Brachial Artery Intima-Media Thickness in Patients with Diabetes with or without Obesity

Paraoxonase activity and coronary heart disease risk in healthy middle-aged males: The PRIME study

Quantitative Assessment of the Influence of Paraoxonase 1 Activity and Coronary Heart Disease Risk

Contact Info

Product

Resources

About