Coronary artery disease in patients with body mass index ≥30 kg/m²: a retrospective chart analysis

Abstract

ObjectiveIn this study, we evaluated obesity as a single risk factor for coronary artery disease (CAD), along with the synergistic effect of obesity and other risk factors.MethodsA retrospective study of 7,567 patients admitted to hospital for chest pain from 2005 to 2014 and underwent cardiac catheterization. Patients were divided into two groups: obese and normal with body mass index (BMI) calculated as ≥30 kg/m2 and <25, respectively. We assessed the modifiable and non-modifiable risk factors in obese patients and the degree of CAD.ResultsOf the 7,567 patients who underwent cardiac catheterization, 414 (5.5%) had a BMI ≥30. Of 414 obese patients, 332 (80%) had evidence of CAD. Obese patients displayed evidence of CAD at the age of 57 versus 63.3 in non-obese patients (p<0.001). Of the 332 patients with CAD and obesity, 55.4% had obstructive CAD versus 44.6% with non-obstructive CAD. In obese patients with CAD, male gender and history of smoking were major risk factors for development of obstructive CAD (p=0.001 and 0.01, respectively) while dyslipidemia was a major risk factor for non-obstructive CAD (p=0.01). Additionally, obese patients with more than one risk factor developed obstructive CAD compared to non-obstructive CAD (p=0.003).ConclusionHaving a BMI ≥30 appears to be a risk factor for early development of CAD. Severity of CAD in obese patients is depicted on non-modifiable and modifiable risk factors such as the male gender and smoking or greater than one risk factor, respectively.

Assessment of Obesity by Using Various Anthropometric Measurements among Patients with Coronary Heart Disease Residing in North India

“…However, obesity from class I-III (BMI: 27.5-37.5 kg/m 2 ) was even more prevalent among 68 (52%) female patients in contrast to 6 (12%) female controls. Furthermore, BMI >30 kg/m 2 has been reported as an independent risk factor for the occurrence of coronary diseases [21]. Besides, individuals with BMI <17.5 or >24.9 kg/m 2 have also been linked with increased CVD mortality among the East Asian population [22].…”

Long-term outcomes of coronary artery bypass surgery in young patients

“…По данным Американской ассоциации сердца и Американского колледжа кардиологии [3], основными факторами развития ИБС являются курение, гипертония, дислипидемия, сахарный диабет, пожилой возраст, мужской пол, ожирение. Результаты КШ у пациентов пожилого возраста изучены во многих исследованиях, в то время как исходы данного вида реваскуляризации миокарда в группе пациентов молодого возраста (моложе 45 лет по классификации ВОЗ) изучены мало и представляют интерес как для сердечно-сосудистых хирургов, так и для кардиологов [1,4]. В частности, нет данных многолетних послеоперационных наблюдений в когорте молодых пациентов [5].…”

Biomarkers and Gene Polymorphisms in Members of Long- and Short-lived Families: A Longevity Study

“…Atherosclerosis is a disease that begins very early in life, even in the prenatal and infancy period, and becomes clinically evident in approximately the 4th or 5th decade of life [ 3 ]. The diseases sharing the atherosclerotic mechanism are mainly Coronary Artery Disease (CAD), Diabetes Mellitus (DM), hypertension, Alzheimer’s Disease (AD) and obesity [ 4 ]. Several genes have been linked to the risk of the progression of these diseases, such as cholesteryl ester transfer protein ( CETP ) [ 5 ], Apolipoprotein E ( ApoE ) [ 6 , 7 ], Angiotensin-Converting Enzyme ( ACE ) [ 8 ] and adiponectin ( ADIPOQ ) [ 9 ].…”