Coronary Artery Disease: From Mechanism to Clinical Practice

Shao, Chunli; Wang, Jingjia; Tian, Jianwei; Tang, Yi-Da

doi:10.1007/978-981-15-2517-9_1

Cited by 130 publications

(107 citation statements)

References 128 publications

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“…For decades, the application of early revascularization techniques post MI, including Percutaneous Coronary Intervention (PCI), has been proved to rapidly restore the blood perfusion of the ischemic region, and signi cantly reduce the short-term mortality [21]. However, the reperfusion injury may be aggravated after revascularization, and the infarcted myocardium cannot be resurrected from death, which may accelerate the occurrence of HF after MI [22].…”

Section: Discussionmentioning

confidence: 99%

HGF Treatment Promotes Cardiac Function and Cardiac Repair: Meta-analysis of Pig Models With Myocardial Infarction

Chen

Wang

et al. 2020

Preprint

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Background: Previous studies reported that hepatocyte growth factor (HGF) could promote angiogenesis and cardiac function after myocardial infarction (MI) in pigs. However, the results of these studies were controversial. To clarify the therapeutic efficacy of local HGF administration after MI, we performed a systematic review and meta-analysis of data from the pig models, which could provide evidence for the feasibility of clinical HGF application.Methods: PubMed, EMBASE, and China National Knowledge Infrastructure were searched for randomized studies that correspond to our subject. The search terms included (hepatocyte growth factor OR HGF) AND (heart failure OR HF OR myocardial infarction OR MI OR AMI OR coronary heart disease OR CHD). The primary endpoint indicators were identified as the left ventricular ejection fraction (LVEF) and capillaries density. Other parameters reflecting cardiac function and ventricular remodeling were analyzed as secondary indicators, including ventricular volume, infarct size, apoptotic index and others.Results: In total, 9 studies were finally included in the meta-analysis. On comparing the cardiac function indexes, the HGF group was found to be better than the control group in regard to LVEF, stroke volume, left ventricular end-systolic volume (LVESV) and left ventricular end-diastolic volume (LVEDV). However, no statistically significant differences were found in heart rate. Furthermore, HGF treatment promotes angiogenesis in ischemic areas, which is manifested by increased capillary density. In addition, the HGF group was found to be better than the control group when it comes to infarct size, arteriole densities, and other indicators of cardiac remodeling.Conclusions: HGF treatment can effectively promote cardiac function and cardiac repair including angiogenesis, and this strategy is a promising cardio-protective approach that merits further clinical studies.

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Section: Discussionmentioning

confidence: 99%

HGF Treatment Promotes Cardiac Function and Cardiac Repair: Meta-analysis of Pig Models With Myocardial Infarction

Chen

Wang

et al. 2020

Preprint

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“…Studies underline different risk factors that are involved in the progression of this condition, among others, high LDL and low HDL cholesterol in plasma, hypertension, diabetes, smoking, sex and age. CAD could open to more severe conditions such as myocardial infarction and heart failure, so, it is important to stop the progression of the pathology lowering existing risk factors [68]. Rajaratnam and colleagues underline that in menopausal women high plasma concentration of squalene could represent a risk factor for CAD: they found higher plasma SQ related to serum cholesterol in women with cardiovascular predisposition to CAD than in controls.…”

Section: Coronary Artery Diseasementioning

confidence: 99%

Squalene: More than a Step toward Sterols

Micera

Botto²,

Geddo

et al. 2020

Antioxidants

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Squalene (SQ) is a natural triterpene widely distributed in nature. It is a metabolic intermediate of the sterol biosynthetic pathway and represents a possible target in different metabolic and oxidative stress-related disorders. Growing interest has been focused on SQ’s antioxidant properties, derived from its chemical structure. Strong evidence provided by ex vivo models underline its scavenging activity towards free radicals, whereas only a few studies have highlighted its effect in cellular models of oxidative stress. Given the role of unbalanced free radicals in both the onset and progression of several cardiovascular diseases, an in depth evaluation of SQ’s contribution to antioxidant defense mechanisms could represent a strategic approach in dealing with these pathological conditions. At present experimental results overall show a double-edged sword role of squalene in cardiovascular diseases and its function has to be better elucidated in order to establish intervention lines focused on its features. This review aims to summarize current knowledge about endogenous and exogenous sources of SQ and to point out the controversial role of SQ in cardiovascular physiology.

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“…In previous decades, cardiovascular researchers have conducted extensive basic and clinical research to explore the pathophysiology of coronary artery disease (CAD) [1,2]. Although the prevention, treatment, and care of CAD patients have greatly improved and adverse cardiovascular events and mortality have declined, the aging population experiences improved quality of life and reduced physical activity, which contributes to the prevalence of CAD remaining high and being the leading cause of death in patients with cardiovascular disease [3].…”

Section: Introductionmentioning

confidence: 99%

A Novel and Simply Calculated Cardiac Load Index Correlates With Coronary Artery Disease

Fan

Liu

et al. 2020

Preprint

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Abstract Background: No cardiac load index (CLI) has been established for patients with coronary artery disease (CAD). We propose a simple method for calculating CLI and explore the association of CLI with CAD.Methods: We enrolled 4145 consecutive inpatients with suspected stable CAD from December 2011 to June 2017 at the Chengde Medical University Affiliated Hospital. All patients were divided into the CAD (n=2914) and the NCAD groups (n=1231) according to coronary computed tomography angiography. We retrospectively collected data and calculated the CLI values of all patients. The receiver operating characteristic diagnostic test analysis was performed with CLI≥77, CLI≥125, CLI≥171, CLI≥217, and CLI≥264, respectively. Multivariate logistic regression models were established to determine the risk factors of CAD. Results: The CLI was significantly higher in the CAD group than in the NCAD group and higher in the male than in the female subgroup (both P<0.001). CLI≥171 was the diagnostic cut-off value. The predictive power of CLI≥171 for CAD improved after considering other risk factors. CLI≥171 is a new independent risk factor for CAD, and is an independent risk factor for CAD in males and females (all P<0.001).Conclusions: Increased CLI is an independent risk factor for CAD, it may be used as a predictor for the prevalence for CAD to improve diagnosis and prevention.

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Coronary Artery Disease: From Mechanism to Clinical Practice

Cited by 130 publications

References 128 publications

HGF Treatment Promotes Cardiac Function and Cardiac Repair: Meta-analysis of Pig Models With Myocardial Infarction

HGF Treatment Promotes Cardiac Function and Cardiac Repair: Meta-analysis of Pig Models With Myocardial Infarction

Squalene: More than a Step toward Sterols

A Novel and Simply Calculated Cardiac Load Index Correlates With Coronary Artery Disease

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