Coronary Artery Disease and Coronary Artery Bypass Grafting in Behcet's Disease

Şişmanoğlu, Mesut; Mansuroğlu, Denyan; Ardal, Hasan; Erentuğ, Vedat; Kaya, Erhan; Güler, Mustafa; İpek, Gökhan; Yakut, Cevat

doi:10.1111/j.0886-0440.2005.200381.x

Cited by 22 publications

(20 citation statements)

References 7 publications

(10 reference statements)

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“…The tissue fragility due to Behcet disease involvement was also observed during surgery, similar to pseudoaneurysms in aortic rootYinvolved Behcet disease. 59 In our series, he was treated with coronary artery bypass graft after premedication with steroid.…”

Section: Coronary Arterymentioning

confidence: 79%

Cardiovascular Behcet Disease

Cho¹,

Lee²,

Choi³

et al. 2008

Journal of Computer Assisted Tomography

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Unusual radiological manifestations of rare complications of cardiovascular Behcet disease (BD) are the following: (a) aneurysm and (b) occlusion in the aorta and its major branches, (c) pseudoaneurysms on the aortic root and coronary artery, and recurrent valvular dehiscence in the heart, (d) venous thrombosis in the deep and superficial venous system and vena cava. The initial exact diagnosis of cardiovascular BD has been extremely difficult for these rare complicated findings, especially in the absence of the florid clinical manifestations of BD. Radiologist should be aware of possibility of cardiovascular BD via familiarity with its rare imaging features, including computed tomographic angiography (and its 3-dimensional reconstructed images), conventional angiography, and with the clinical characteristics of BD because of high mortality of cardiovascular BD.

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Section: Coronary Arterymentioning

confidence: 79%

Cardiovascular Behcet Disease

Cho¹,

Lee²,

Choi³

et al. 2008

Journal of Computer Assisted Tomography

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“…We think that myocardial perfusion in Cardio-Behçet should be preferentially evaluated with MPS due to the facts that 1, CAG is an invasive procedure and frequently produces normal results; 2, OS markers do not show a correlation with myocardial perfusion impairment according to our findings; and 3, invasive procedures is not recommended due to the increased tissue fragility [19,36].…”

Section: Discussionmentioning

confidence: 79%

No apparent correlation between Behçet’s disease and oxidative stress disturbance

Sağlam

Kaya

Cemek

et al. 2010

Clinical Hemorheology and Microcirculation

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Behçet's disease (BD) is a chronic, progressive and inflammatory multisystemic disease, that significantly affects the cardiovascular system. Oxidative stress (OS) is a disturbance in oxidant/antioxidant balance in favor of oxidants. The OS that increases acutely and chronically due to the inflammatory process plays an important role in the pathogenesis of the cardiovascular system effects of the disease by causing endothelial dysfunction in vascular structures. The aim of our study was to investigate the relationship between OS and myocardial perfusion, which is based on microvascular dysfunction, in BD.Material and method: Twenty-seven patients with BD (16 M, 11 F, mean age: 38.7 ± 9.4 years) and 22 healthy volunteers (12 M, 10 F, mean age: 35.8 ± 6.5 years) participated in our study. Technetium-99m methoxyisobutylisonitrile single photon emission computed tomography (Tc-99m MIBI SPECT) stress-rest test was performed with two-day protocol. Myocardial perfusion scores (summed stress score, summed rest score, summed difference score, fix defect score) and perfusion defect prevalence (stress, rest, ischemic and fixed) were determined as the percentage of left ventricle. Coronary angiography was performed in patients with abnormal myocardial perfusion scintigraphy. For OS analysis, the blood samples were taken immediately before the first imaging procedure and were studied for malondialdehyde, glutathione, nitrite, nitrate, vitamin C, retinol, and carotene.Results: In the BD group, a total of 9 patients had abnormal findings in their stress and rest electrocardiography. Perfusion defect in myocardial perfusion scintigraphy was observed in 14 patients (51.8%). Twelve patients accepted coronary angiography, and their results were normal. In the comparison of myocardial perfusion scores, perfusion defect prevalence and OS parameters, there was a significant difference between the BD and control groups. In the BD group, no correlation was observed between myocardial perfusion scores, perfusion defect prevalence and OS parameters.Conclusion: Defects in myocardial perfusion and increase in OS were observed in BD; however, there was no correlation between the two findings in the inactive period. In other words, the prevalence and intensity of myocardial perfusion defects can vary at different OS levels.

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“…Uncertainties surround the issue of thrombolysis, anticoagulation and coronary angioplasty in acute coronary syndromes in BD [123]. Further studies, aimed to compare different antithrombotics and/or immunosuppressive agents on large samples, are warranted to provide the clinician with recommendations over the safety and effectiveness of antithrombotic therapy in BD.…”

Section: Discussionmentioning

confidence: 99%

Behcet's Disease as a Model of Venous Thrombosis~!2009-11-07~!2009-12-07~!2010-02-22~!

Regina¹,

Gasparyan²,

Orlandini³

et al. 2010

TOCMJ

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Behçet’s disease (BD) is a chronic inflammatory disease of unknown aetiology characterized by recurrent oral, genital aphthous ulcerations, uveitis, skin lesions and other multisystem affections associated with vasculitis. Different types of vessels, predominantly veins, can be affected in BD. The frequency of vascular lesions in BD, such as superficial and deep venous thromboses, arterial aneurysms and occlusions, ranges between 7-29%. In this review, various factors of thrombogenesis in BD, particularly pro- and antithrombotic endothelial and non-endothelial factors, factors of coagulation, platelet activation and rheological changes are presented and discussed from positions of Virchow’s triad of venous thrombosis. Despite advances in understanding of thrombogenesis in BD, still many issues of diagnosis and targeted preventive and therapeutic measures remain unresolved. Further studies are needed to clarify the pathobiology of BD-related thrombosis and to provide the clinicians with recommendations over the utility, safety and effectiveness of the antithrombotic therapy in BD.

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Coronary Artery Disease and Coronary Artery Bypass Grafting in Behcet's Disease

Cited by 22 publications

References 7 publications

Cardiovascular Behcet Disease

Cardiovascular Behcet Disease

No apparent correlation between Behçet’s disease and oxidative stress disturbance

Behcet's Disease as a Model of Venous Thrombosis~!2009-11-07~!2009-12-07~!2010-02-22~!

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