2013
DOI: 10.1148/radiol.13122529
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Coronary Artery Calcium Scoring to Exclude Flow-Limiting Coronary Artery Disease in Symptomatic Stable Patients at Low or Intermediate Risk

Abstract: A CAC score of zero in stable patients at low or intermediate risk excludes flow-limiting CAD. These findings support the possibility of CAC scoring as a simple and safe tool to select patients for additional testing or discharge, as recommended in the literature.

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Cited by 50 publications
(29 citation statements)
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“…As patients with a CAC score of 0 demonstrated excellent prognosis independent of SPECT findings, the additional CAC score is likely to reduce the use of downstream invasive testing in this subset of patients. 22 After multivariate analysis, both CAC score and SPECT were independently associated with MACE. For patients with a CAC score ≥100, a stepwise increase of risk for events was present with higher CAC scores.…”
Section: Discussionmentioning
confidence: 98%
“…As patients with a CAC score of 0 demonstrated excellent prognosis independent of SPECT findings, the additional CAC score is likely to reduce the use of downstream invasive testing in this subset of patients. 22 After multivariate analysis, both CAC score and SPECT were independently associated with MACE. For patients with a CAC score ≥100, a stepwise increase of risk for events was present with higher CAC scores.…”
Section: Discussionmentioning
confidence: 98%
“…8 According to the most recent American Heart Association (AHA) 9 and American College of Cardiology Foundation (ACCF)/AHA 10 guidelines, CAC has Class IIA and IIB recommendations for assessing risk in intermediate and low-to-intermediate asymptomatic patients, respectively, and in guiding management of hyperlipidemia. 11 Studies also indicate that CAC may accurately risk stratify both low risk stable patients with new onset chest pain 12,13 and those presenting to the emergency department with acute chest pain, and has a Class IIB recommendation for use in symptomatic individuals. 9,14 It should be noted that CAC does not test for obstructive disease or functional ischemia, but rather is a surrogate for coronary atherosclerotic plaque burden.…”
Section: Introductionmentioning
confidence: 99%
“…NICE guidelines currently recommend CT calcium scoring when in patients with a low (10%–29%) likelihood of CAD. There is emerging evidence that extending CT calcium scoring to patients with low and intermediate pretest probability of CAD, in addition to (but not in place of) clinical assessment could also improve CAD prediction 8 25 26. The availability of this test to RACPC clinicians, although increasing, is still variable.…”
Section: Discussionmentioning
confidence: 99%