Coronary Artery Calcifications in Hemodialysis Patients and Their Correlation With the Prevalence of Erectile Dysfunction

İnci, Kubilay; Hazırolan, Tuncay; Aki, Fazıl Tuncay; Oruc, Ozgur; Tombul, Şevket Tolga; Taşar, Ç.; Erkan, I.; Bakkaloḡlu, M.; Turgan, Çetin; Ergen, Ali

doi:10.1016/j.transproceed.2007.11.046

Cited by 18 publications

(14 citation statements)

References 27 publications

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“…Rodger, Fletcher and Devar et al studied 100 patients with CKD on maintenance haemodialysis and found ED in 61% of patients. 12 Similar prevalence of ED was observed in studies done in Iran (87.5%), 13 Turkey (82.9%), 14 Egypt (82.5%) and Brazil (86.4%). 15 Causes of erectile dysfunction in patients on HD is multifactorial which includes metabolic causes, disruption of the HPA axis, [16][17] alteration in plasma levels of gonadotropins, testosterone, prolactin 18 and zinc, [19][20] medications like beta-blockers and antidepressants are responsible for ED.…”

Section: Discussionsupporting

confidence: 73%

Erectile Dysfunction in Haemodialysis Patients- A Cross-Sectional Study at Vaatsalya Hospital, Shimoga, India

Girish¹,

Praveen²

2018

jemds

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BACKGROUNDWith the advancement in the medical treatment and haemodialysis techniques, life expectancy of ESRD patients has increased significantly, and this fact has highlighted the importance of quality of life of HD patients. Sexual dysfunction is most commonly seen in patients with ESRD on maintenance haemodialysis in the form of erectile dysfunction, decreased libido and decreased frequency of sexual intercourse.The proposal of this study was to determine the prevalence of erectile dysfunction (ED) among haemodialysis (HD) patients. MATERIALS AND METHODSA cross-sectional study was conducted to determine the prevalence of ED among a community-based haemodialysis (HD) population at Vaatsalya Hospital, Shimoga. The presence and severity of ED were assessed among 50 ESRD patients using the selfadministered International Index of Erectile Function-5 (IIEF-5). Clinical, demographic and laboratory data of all patients were collected from June 2017 to November 2017. RESULTS60 patients on MHD were assessed. 5 were excluded due to cognitive dysfunction. 3 did not consent. 2 had problems with communication. 50 patients were included in the final cohort. Nearly, all were hypertensive (94%) and 58% had diabetes. The cause of ESRD was Diabetes (58%), Hypertension (6%), Nephritis (20%) and others (16%). The prevalence of ED was 82% (CI, 76 to 87%) for all HD subjects. Majority of the patients had mild-to-moderate dysfunction (48%) and about 34% of patients had severe erectile dysfunction.CONCLUSION ED is extremely prevalent among HD patients. Early intervention may change quality of life of these patients. Sexual dysfunction is most commonly seen in patients with ESRD on maintenance haemodialysis in the form of erectile dysfunction, decreased libido and decreased frequency of sexual intercourse. [2][3] Many studies in men with ESRD have shown that prevalence of ED in men with ESRD on HD may range from 41.5% to 82% and is directly associated with severity of the illness. 4-8 Erectile dysfunction (ED) is a medical problem that alters patient's quality of life due to association with many problems such as anxiety, loss of selfesteem, depression and marital misfit. 9 ED is defined as the 'Financial or Other Competing Interest': None. KEYWORDS

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Section: Discussionsupporting

confidence: 73%

Erectile Dysfunction in Haemodialysis Patients- A Cross-Sectional Study at Vaatsalya Hospital, Shimoga, India

Girish¹,

Praveen²

2018

jemds

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“…Indeed, an association has been shown between severe ED and coronary artery calcium score in dialysis patients (29) and between ED and carotid intima-media thickness in hemodialysis recipients (30). …”

Section: Ed In Ckdmentioning

confidence: 99%

Male Sexual Dysfunction and Chronic Kidney Disease

Edey

2017

Front. Med.

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Male sexual dysfunction is common in chronic kidney disease (CKD), particularly in end-stage renal disease. Historically, this cause of considerable morbidity has been under-reported and under-recognized. The ideal approach to diagnosis and management remains unclear due to a paucity of good quality data, but an understanding of the pathophysiology is necessary in order to address the burden of this important complication of CKD. This paper will review the endocrine dysfunction that occurs in renal disease, particularly the hypothalamic–pituitary–gonadal axis, discuss the causes of erectile dysfunction, infertility, and altered body image and libido in these patients and suggest appropriate treatment interventions.

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“…In addition to typical cardiovascular disease risk factors, end stage renal disease patients have impaired calcium and phosphorus homeostasis, deficiency of calcification inhibitors and receive high doses of vitamin D treatment, factors which have shown to promote the vascular calcification process [48] . In the general population, it has been reported that erectile dysfunction is associated with silent coronary disease as patients experiencing sexual dysfunction symptoms tend to have higher coronary artery calcification scores even in the absence of angina symptoms [49,50] , a finding which is additionally observed among hemodialysis patients with severe ED, who also tend to present greater coronary artery calcium scores [3] . In a retrospective cohort study of 12825 ED patients, it was reported that there was a two-fold increase in the risk of acute myocardial infarction among men with ED [51] .…”

Section: Effect Of Comorbiditiesmentioning

confidence: 96%

“…The cause is generally multifactorial with psychological, neurological, endocrinological, vascular and iatrogenic factors acting in concert to increase the likelihood of ED [2] . A number of recent studies suggest an association between endothelial dysfunction and ED [3] . This review aims to analyze the pathophysiology of ED in patients with CKD, to present its prevalence rates in various stages of CKD, to highlight comorbid conditions and common risk factors, which both diseases share and, eventually, to discuss possible therapeutic options, which might improve sexual function of CKD patients.…”

Section: Introductionmentioning

confidence: 99%

Erectile dysfunction in chronic kidney disease: From pathophysiology to management

Papadopoulou

Varouktsi

Lazaridis

et al. 2015

WJN

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Chronic kidney disease (CKD) is encountered in millions of people worldwide, with continuously rising incidence during the past decades, affecting their quality of life despite the increase of life expectancy in these patients. Disturbance of sexual function is common among men with CKD, as both conditions share common pathophysiological causes, such as vascular or hormonal abnormalities and are both affected by similar coexisting comorbid conditions such as cardiovascular disease, hypertension and diabetes mellitus. The estimated prevalence of erectile dysfunction reaches 70% in end stage renal disease patients. Nevertheless, sexual dysfunction remains under-recognized and under-treated in a high proportion of these patients, a fact which should raise awareness among clinicians. A multifactorial approach in management and treatment is undoubtedly required in order to improve patients' quality of life and cardiovascular outcomes.

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Coronary Artery Calcifications in Hemodialysis Patients and Their Correlation With the Prevalence of Erectile Dysfunction

Cited by 18 publications

References 27 publications

Erectile Dysfunction in Haemodialysis Patients- A Cross-Sectional Study at Vaatsalya Hospital, Shimoga, India

Erectile Dysfunction in Haemodialysis Patients- A Cross-Sectional Study at Vaatsalya Hospital, Shimoga, India

Male Sexual Dysfunction and Chronic Kidney Disease

Erectile dysfunction in chronic kidney disease: From pathophysiology to management

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