Coronary artery calcification and risk factors for atherosclerosis in patients with venous thromboembolism

Hong, Cheng; Zhu, Fang; Du, Duanming; Pilgram, Thomas K.; Sicard, Gregorio A.; Bae, Kyongtae T.

doi:10.1016/j.atherosclerosis.2005.03.047

Cited by 107 publications

(84 citation statements)

References 32 publications

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“…In a case-control study, Hong and colleagues found a higher prevalence of coronary artery calcium, as assessed by chest computed tomography (CT) scan, in patients with unprovoked VTE than in matched control individuals. 8 In a series of almost 24,000 consecutive autopsies, Eliasson and colleagues found an increased prevalence of VTE in patients with arterial thrombosis, except for those with coronary artery thrombosis. 9 Recently, Ageno and colleagues reviewed the evidence favoring the association of the most important risk factors for atherosclerosis and VTE.…”

Section: Association Between Venous Thromboembolism (Vte) and Atherosmentioning

confidence: 99%

Venous and arterial thrombosis: Two aspects of the same disease?

Prandoni

2009

European Journal of Internal Medicine

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An increasing body of evidence suggests the likelihood of a link between venous and arterial thrombosis. The two vascular complications share several risk factors, such as age, obesity, diabetes mellitus, blood hypertension, hypertriglyceridemia, and metabolic syndrome. Moreover, there are many examples of conditions accounting for both venous and arterial thrombosis, such as the antiphospholipid antibody syndrome, hyperhomocysteinemia, malignancies, infections, and the use of hormonal treatment. Finally, several recent studies have consistently shown that patients with venous thromboembolism are at a higher risk of arterial thrombotic complications than matched control individuals. We, therefore, speculate the two vascular complications are simultaneously triggered by biological stimuli responsible for activating coagulation and infl ammatory pathways in both the arterial and the venous system. Future studies are needed to clarify the nature of this association, to assess its extent, and to evaluate its implications for clinical practice.

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Section: Association Between Venous Thromboembolism (Vte) and Atherosmentioning

confidence: 99%

Venous and arterial thrombosis: Two aspects of the same disease?

Prandoni

2009

European Journal of Internal Medicine

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“…16,17 Several reports suggest that there is a close association between components of the CHA 2 DS 2 -VASc score and risk of VTE. [18][19][20][21][22][23][24][25] From this point of view, we speculated the hypothesis that higher CHA 2 DS 2 -VASc scores might be associated with risk of mortality in patients with APE.…”

Section: Introductionmentioning

confidence: 99%

Higher CHA₂DS₂-VASc Score Is Associated With Increased Mortality in Acute Pulmonary Embolism

Onuk

Karataş

İpek

et al. 2016

Clin Appl Thromb Hemost

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Background: CHA 2 DS 2 -VASc score has been validated in risk prediction for stroke and thromboembolism in patients with atrial fibrillation (AF). Association of CHA 2 DS 2 -VASc score with higher risk of venous thromboembolism and pulmonary embolism (PE) has also been shown. In this study, we investigated the long-term prognostic value of CHA 2 DS 2 -VASc score in patients with acute pulmonary embolism (APE). Methods: Consecutive patients with APE presenting to our emergency department were retrospectively recruited. Patients with AF and who died secondary to causes other than PE were excluded from the study. The CHA 2 DS 2 -VASc score and pulmonary embolism severity index (PESI) were calculated. Results: Two hundred seventy seven participants were included in the study. The mortality rate was 18.7%. Twenty-two cases died within 30 days, and 30 cases died during the follow-up period (median: 13 months). The mean CHA 2 DS 2 -VASc score was significantly higher in dead patients compared to survivors (3.61 + 1.35 vs 1.95 + 1.52, P < .01). In multivariate regression analysis, systolic pulmonary artery pressure (hazard ratio [HR]: 1.03, 95% confidence interval [CI]: 1.01-1.06, P ¼ .02), PESI score (HR: 1.010, 95% CI: 1.004-1.017, P < .01), and CHA 2 DS 2 -VASc score (HR: 1.67, 95% CI: 1.19-2.16, P < .01) were found to be independently correlated with mortality. The patients whose CHA 2 DS 2 -VASc score was between 1 and 3 had 5.67 times and patients whose CHA 2 DS 2 -VASc score was 4 had 16.8 times higher risk of mortality compared to patients with CHA 2 DS 2 -VASc score ¼ 0. Conclusion: Patients with higher CHA 2 DS 2 -VASc scores had higher rates of mortality after APE.

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“…There is accumulating evidence for an association between VTE and atherosclerosis. [3][4][5][6][7] VTE and atherosclerosis may share common risk factors. For example, obesity in general and abdominal obesity in particular are also well accepted risk factors for VTE and were reported to be associated with impaired fibrinolytic activity, which may be a predisposing mechanism to arterial as well as to venous thrombosis.…”

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confidence: 99%

“…Our data and those from the literature may strengthen the hypothesis of an association between atherosclerosis and venous thrombosis, which is the subject of animated discussion. [3][4][5][6][7]13,14,32,33 Analyzing the components of the metabolic syndrome individually, abdominal obesity was demonstrated to be of predictive value for both coronary heart disease and VTE. 9,34 Dyslipidemia has long been known to be a risk factor for atherothrombotic disorders.…”

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confidence: 99%

Venous thromboembolism a manifestation of the metabolic syndrome

Ay¹,

Tengler²,

Vormittag³

et al. 2007

Haematologica

137

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Background and ObjectivesThe metabolic syndrome, defined by abdominal obesity, elevation of blood pressure, fasting glucose and triglycerides and low levels of high-density lipoprotein cholesterol is associated with atherosclerotic disease. It induces a pro-inflammatory and prothrombotic state. Despite its high prevalence, data on the association with venous thromboembolism (VTE) are scarce. The aim of our study was to elucidate the association of the metabolic syndrome with the risk of VTE. Design and MethodsWe conducted a case-control study to investigate the presence of the metabolic syndrome defined according to guidelines of the National Cholesterol Education Program, in high-risk patients with objectively confirmed recurrent VTE, who had had at least one unprovoked event of deep venous thrombosis or pulmonary embolism. Age and sex-matched healthy individuals served as controls. ResultsA total of 116 patients and 129 controls were enrolled. The prevalence of the metabolic syndrome was statistically significantly higher in patients (40/116, 35%) than in controls (26/129, 20%, p=0.012 Interpretation and ConclusionsThe metabolic syndrome may contribute to the development of VTE and is associated with a two-fold increased risk of VTE.

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Coronary artery calcification and risk factors for atherosclerosis in patients with venous thromboembolism

Cited by 107 publications

References 32 publications

Venous and arterial thrombosis: Two aspects of the same disease?

Venous and arterial thrombosis: Two aspects of the same disease?

Higher CHA₂DS₂-VASc Score Is Associated With Increased Mortality in Acute Pulmonary Embolism

Venous thromboembolism a manifestation of the metabolic syndrome

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Coronary artery calcification and risk factors for atherosclerosis in patients with venous thromboembolism

Cited by 107 publications

References 32 publications

Venous and arterial thrombosis: Two aspects of the same disease?

Venous and arterial thrombosis: Two aspects of the same disease?

Higher CHA2DS2-VASc Score Is Associated With Increased Mortality in Acute Pulmonary Embolism

Venous thromboembolism a manifestation of the metabolic syndrome

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Higher CHA₂DS₂-VASc Score Is Associated With Increased Mortality in Acute Pulmonary Embolism