Coronary Artery Aneurysm Induced by Kawasaki Disease in Children Show Features Typical Senescence

Nationwide Survey of Patients With Giant Coronary Aneurysm Secondary to Kawasaki Disease 1999–2010 in Japan

“…Every student undergoes an initial electrocardiogram screening, and cardiac diseases are diagnosed through the second and third screening examinations. When such a diagnosis is made, a school activity management classification 16 and reduced shear stress in giant aneurysm patients. 17 Shear stress is proportional to bloodstream velocity and inversely proportional to vessel diameter.…”

Multicenter and Retrospective Case Study of Warfarin and Aspirin Combination Therapy in Patients With Giant Coronary Aneurysms Caused by Kawasaki Disease

“…1,2 Although intravenous gamma globulin infusion is the currently the recommended treatment, a certain number of patients still develop coronary aneurysms, 1,2 which undergo senescence, 3 leading to higher long-term mortality in male patients with KD. 4 In particular, coronary aneurysms with diameter ≥8.0 mm are categorized as giant coronary aneurysms (GA) and are known to predispose to acute thrombotic occlusion, leading to acute myocardial infarction (AMI) and future stenosis, again leading to ischemic heart disease.…”

Premature Atherosclerosis Long After Kawasaki Disease

“…Furthermore, vascular senescence, demonstrated as increased -galactosidase activity, adhesion molecules and pro-inflammatory cytokines, as well as a reduction of normal physiological vascular proteins, such as eNOS, was increased in KD with CALs. These findings were more remarkable in intima as well as in vasculature of vasa vasorum (Fukazawa et al, 2007). Inevitably, adult atherosclerosis originates from the intimal side of the arteries.…”