Coronary artery- and aortic valve calcifications in patients with Philadelphia-negative myeloproliferative neoplasms

Solli, Camilla Nordheim; Chamat-Hedemand, Sandra; Elming, Hanne; Ngô, Anh Dung; Kjær, Lasse; Skov, Vibe; Sørensen, Anders Lindholm; Ellervik, Christina; Fuchs, Andreas; Sigvardsen, Per E; Kühl, Jørgen Tobias; Kofoed, Klaus F.; Nordestgaard, Børge G.; Hasselbalch, Hans Carl; Bruun, Niels Eske

doi:10.1016/j.ijcard.2022.06.029

Cited by 8 publications

(21 citation statements)

References 40 publications

(59 reference statements)

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“…Flowchart of the MPN cohort. The cohort has also been presented in a previous study, focusing on differences in CACS and AVC between patients with MPNs and a control group from the general population 7 . AVC, aortic valve calcification; CACS, coronary artery calcium score; CT, computed tomography; MPN, myeloproliferative neoplasms.…”

Section: Resultsmentioning

confidence: 99%

“…In a recent review on the pathogenesis of cardiovascular events in patients with MPNs, it is stated that ‘atherosclerosis seems to be favoured by JAK2V717F blood cells, but that there is a need for more data on MPN and atherosclerosis in human cohorts’ 3 . To our knowledge, only three studies on patients with MPNs and coronary atherosclerosis have been published, making this a relatively new research territory, even though the link was proposed years ago 7,19–21 . However, none of these studies have investigated the relationship between VAF and coronary atherosclerosis.…”

Section: Discussionmentioning

confidence: 99%

“…However, none of these studies have investigated the relationship between VAF and coronary atherosclerosis. The studies have shown that there is an increased prevalence of severe coronary atherosclerotic plaques in patients with MPNs compared to controls from the general population and that there is a lack of correlation between the Framingham risk score and the coronary calcium burden in JAK2V617F positive ET patients 7,20 . An association between higher VAF and arterial thrombosis in JAK2V617F positive PV and ET patients have been reported, but other studies have not found this association 22–25 .…”

Section: Discussionmentioning

confidence: 99%

“…We recruited patients with MPNs from a haematological outpatient clinic in Eastern Denmark, between 2016 and 2018 7 . Eligible patients with a diagnosis of PV, ET, or MF according to the WHO 2008 criteria of MPN classification were included 8 .…”

Section: Methodsmentioning

confidence: 99%

“…Inflammation and atherosclerosis are closely linked, and leucocyte activation is recognized as a key player in the development of atherosclerosis, the leading cause of thrombosis in the coronary arteries 5,6 . We have previously shown that patients with MPNs have a higher prevalence of severe coronary atherosclerosis, defined as a coronary artery calcium score (CACS) >400, as well as a higher prevalence of calcifications of the aortic valve (AVC) 7 . However, it is not known whether the JAK2V617F mutation is associated with a higher burden of cardiac calcifications in patients with MPNs.…”

Section: Introductionmentioning

confidence: 99%

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High JAK2V617F variant allele frequency is associated with coronary artery but not aortic valve calcifications in patients with Philadelphia‐negative myeloproliferative neoplasms

Solli

Chamat-Hedemand

Elming

et al. 2023

European J of Haematology

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Background Patients with Philadelphia‐negative myeloproliferative neoplasms (MPNs) have a higher burden of cardiac calcifications compared to the general population. It is not known whether the JAK2V617F mutation is associated with increased cardiac calcification. Aim To investigate if a higher JAK2V617F variant allele frequency (VAF) is associated with severe coronary atherosclerosis and the presence of aortic valve calcification (AVC). Methods Patients with MPNs were examined by cardiac computer tomography to establish coronary artery calcium score (CACS) and AVC score. The first VAF after diagnosis was registered. Severe coronary atherosclerosis was defined as a CACS >400 and AVC was defined as an AVC score >0. Results Among 161 patients, 137 were JAK2V617F mutation‐positive, with a median VAF of 26% (interquartile range 12%–52%). A VAF in the upper quartile range was associated with a CACS >400 [odds ratio (OR) 15.96, 95% confidence interval [CI] 2.13–119.53, p = .0070], after adjustment for cardiovascular risk factors and MPN subtype. An association was not found for the presence of AVC (OR 2.30, 95% CI 0.47–11.33, p = 0.31). Conclusion In patients with MPNs, there is a significant association between having a VAF in the upper quartile (>52%), and severe coronary atherosclerosis, defined as a CACS >400. The presence of AVC is not associated with VAF.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%