Coronary artery 18F-NaF PET analysis with the use of an elastic motion correction software

Bellinge, J.; Majeed, Kamran; Carr, Stuart S.; Jones, J.P.; Hong, Inki; Francis, Roslyn J.; Schultz, Carl

doi:10.1007/s12350-018-01587-7

Cited by 11 publications

(13 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nonetheless, a number of observations, listed below, may hold true, whereas other questions remain unanswered. Most 2019 papers on NaF-PET imaging focus on unstable or what is designated vulnerable plaque morphology and detection in predominantly the coronary arteries often employing advanced methodologies [49,56,[58][59][60][61][62][63]. In August 2019, the first study on the efficacy of therapy judged by NaF-PET imaging appeared.…”

Section: Limitationsmentioning

confidence: 99%

Atherosclerosis imaging with 18F-sodium fluoride PET: state-of-the-art review

Høilund‐Carlsen

Sturek

Alavi

et al. 2019

Eur J Nucl Med Mol Imaging

View full text Add to dashboard Cite

Purpose We examined the literature to elucidate the role of 18F-sodium fluoride (NaF)-PET in atherosclerosis. Methods Following a systematic search of PubMed/MEDLINE, Embase, and Cochrane Library included articles underwent subjective quality assessment with categories low, medium, and high. Of 2811 records, 1780 remained after removal of duplicates. Screening by title and abstract left 41 potentially eligible full-text articles, of which 8 (about the aortic valve (n = 1), PET/ MRI feasibility (n = 1), aortic aneurysms (n = 1), or quantification methodology (n = 5)) were dismissed, leaving 33 published 2010-2012 (n = 6), 2013-2015 (n = 11), and 2016-2018 (n = 16) for analysis. Results They focused on coronary (n = 8), carotid (n = 7), and femoral arteries (n = 1), thoracic aorta (n = 1), and infrarenal aorta (n = 1). The remaining 15 studies examined more than one arterial segment. The literature was heterogeneous: few studies were designed to investigate atherosclerosis, 13 were retrospective, 9 applied both FDG and NaF as tracers, 24 NaF only. Subjective quality was low in one, medium in 13, and high in 19 studies. The literature indicates that NaF is a very specific tracer that mimics active arterial wall microcalcification, which is positively associated with cardiovascular risk. Arterial NaF uptake often presents before CT-calcification, tends to decrease with increasing density of CT-calcification, and appears, rather than FDG-avid foci, to progress to CT-calcification. It is mainly surface localized, increases with age with a wide scatter but without an obvious sex difference. NaF-avid microcalcification can occur in fatty streaks, but the degree of progression to CT-calcification is unknown. It remains unknown whether medical therapy influences microcalcification. The literature held no therapeutic or randomized controlled trials. Conclusion The literature was heterogeneous and with few clear cut messages. NaF-PET is a new approach to detect and quantify microcalcification in early-stage atherosclerosis. NaF uptake correlates with cardiovascular risk factors and appears to be a good measure of the body's atherosclerotic burden, potentially suited also for assessment of anti-atherosclerotic therapy.

show abstract

Section: Limitationsmentioning

confidence: 99%

Atherosclerosis imaging with 18F-sodium fluoride PET: state-of-the-art review

Høilund‐Carlsen

Sturek

Alavi

et al. 2019

Eur J Nucl Med Mol Imaging

View full text Add to dashboard Cite

show abstract

“…Elastic motion correction (eMOCO) is usually used in PET/CT to correct for cardiac and respiratory motions in PET images, which has proven to be effective [24][25][26] .…”

Section: Discussionmentioning

confidence: 99%

“…This suggests a dependency of the cardiac and dual gating modes on the correction technique. One explanation is that the eMOCO algorithm, when applied to all phases of the cardiac cycle (8 phases), includes the counts of all cardiac gates into the reference gate 24 .…”

Section: Discussionmentioning

confidence: 99%

“…The eMOCO algorithm was implemented in the e7-toolbox (Siemens Molecular Imaging, Knoxville, USA) 24 and was used to correct the PET-data in phantom as well as patient data retrospectively. The technique produces a single deblurring kernel from the reference frame using the concept of mass preservation approach and applied to each gate as the motion model for respective correction 17 .…”

Section: Emoco Correctionmentioning

confidence: 99%

See 1 more Smart Citation

Respiratory and cardiac motion correction in PET using elastic motion approach for simultaneous abdomen and thorax PET/MRI.

Farag

Schaefferkoetter

Kohan

et al. 2022

Preprint

Self Cite

View full text Add to dashboard Cite

Background: Cardiac and respiratory motions in clinical positron emission tomography (PET) is a major contributor to inaccurate PET quantification and lesion characterisation. In this study, an elastic motion-correction (eMOCO) technique based on mass preservation optical flow is adapted and investigated for PET/MR applications. Methods: The eMOCO technique was investigated in a motion management QA phantom and in twenty-four patients who underwent PET/MR for dedicated liver imaging and nine patients for cardiac PET/MR evaluation. Data were acquired and then reconstructed with different gating modes and motion correction techniques and compared to static images. Standardized uptake value (SUV), signal-to-noise ratio (SNR) of lesions activities from each gating mode and correction technique were measured and there means/standard deviation (STD) were compared using 2-ways ANOVA analysis and post-hocTukey’s test.Results: Lesions’ s SNR are highly recovered from phantom and patient studies. The STD of the SUV resulted from the eMOCO technique was statistically significantly less (p<0.01) than the STD resulted from conventional gated and static SUVs at the liver, lung and heart.Conclusions: The eMOCO technique was successfully implemented in PET/MR imaging in a clinical setting and produced the lowest STD compared to gated and static images, and hence provided the least noisy PET images. Therefore, the eMOCO technique can potentially be used on PET/MRI for improved respiratory and cardiac motion correction.

show abstract

“…Motion correction of the aortic valve improves signal to noise ration and tissue-tobackground ratio compared to current standard approaches 15 Coronary motion correction technology improves image noise and improves lesion tissue-tobackground ratios 16,17 Partial volume effect correction of atherosclerotic lesions improves tissue-to-background ratios 18 Compensation for patient motion improves coronary lesion tissue-to-background ratios 19 Compensation for respiratory motion, cardiac motion and gross patient motion improves testretest reproducibility of coronary analysis 20 The current study shows that background correction of vertebral 18 F-NaF activity omits the requirement for manual exclusion of vertebral radiotracer activity from aortic analysis 5 unexpected finding. Regions of low or absent radiotracer activity may have arbitrary readings when quantified using standardized methods such as the maximum tissue-to-background ratio, in part due to the disproportionate effects of small variations in blood pool activity among other factors.…”

Section: Reconstruction Methods To Improve Analysis Of Arterial 18 F-mentioning

confidence: 99%