Coronary angioplasty in identical twins

Cokkinos, Philip; Sbarouni, Eftihia; Kremastinos, Dimitrios Th.

doi:10.1016/j.ijcard.2005.03.068

Cited by 3 publications

(1 citation statement)

References 7 publications

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“…Several cases of coronary artery disease in identical twins have been reported [ 7 – 11 ], showing the similarities in the coronary anatomy and atherosclerotic lesions in identical twins, as in the present case report. Interestingly, Turley et al described a pair of identical twins presenting almost simultaneously with coronary artery disease and identical atherosclerotic lesions despite significant differences in their environmental risk factors and geographic location (12 000 miles apart) [ 9 ].…”

Section: Discussionsupporting

confidence: 80%

Vasospastic Angina in Identical Twins

et al. 2015

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Patient: Male, 58Final Diagnosis: Vasospastic anginaSymptoms: Chest painMedication: —Clinical Procedure: Medical treatmentSpecialty: CardiologyObjective:Rare diseaseBackground:The clinical conditions of various diseases, including coronary artery disease, are determined by genetics and the environment. Previous investigations noted the significance of genetic mutations and polymorphisms in cases of coronary spasm.Case Report:We report on monozygotic identical twins who almost simultaneously presented with vasospastic angina. The 58-year-old younger twin was admitted to our hospital because of persistent chest pain. An electrocardiogram showed an inverted T wave in the left precordial leads. Coronary angiographies revealed a short left main trunk (LMT) and 50% stenosis at the proximal portion of the left anterior descending artery (LAD). Infusion of acetylcholine to his left coronary artery caused marked vasoconstriction associated with a sensation of chest oppression. Nitroglycerine completely reversed this response. Based on these findings, we diagnosed Twin A with vasospastic angina. At nearly the same time, his identical twin brother was diagnosed with vasospastic angina at another hospital. Comparison of both coronary angiograms indicated similar structure of coronary vessels, including short LMT and mild stenosis at the proximal portion of LAD.Conclusions:These 2 cases highlight the importance of genetic factors in the pathogenesis of vasospastic angina. It may be important for individuals to receive medical attention if their identical twin presents with vasospastic angina.

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Section: Discussionsupporting

confidence: 80%

Vasospastic Angina in Identical Twins

et al. 2015

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Monozygotic Twins with Identical Cardiac Conditions

Sarmast¹,

Schussler²

2011

Baylor University Medical Center Proceedings

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Concomitant Coronary Artery Disease in Identical Twins: Case Report and Systematic Literature Review

Kamzolas,

Papazoglou,

Gemousakakis

et al. 2023

JCM

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Coronary artery disease (CAD) is multifactorial and strongly affected by genetic, epigenetic and environmental factors. Several studies have reported development of concomitant CAD in identical twins. We report a case in which a pair of Caucasian male monozygotic twins presented almost concomitantly with acute coronary syndrome (ACS) and had concordant coronary anatomy and identical site of occlusion. We performed a systematic literature review of PubMed, Web Of Science and Scopus databases from inception until 28 February 2023 of case reports/case series reporting the concomitant development of CAD in monozygotic twins. We found 25 eligible case reports with a total of 31 monozygotic twin pairs (including the case from our center) suffering from CAD and presenting (most of them simultaneously) with ACS (mean age of presentation: 45 ± 12 years, males: 81%). Coronary angiograms demonstrated lesion and anatomy concordance in 77% and 79% of the twin pairs, respectively. Screening for disease-related genetic mutations was performed in six twin pairs leading to the identification of five CAD-related genetic polymorphisms. This is the first systematic literature review of studies reporting identical twin pairs suffering from CAD. In summary, there is high concordance of coronary anatomy and clinical presentation between monozygotic twins. Future monozygotic twin studies—unbiased by age effects—can provide insights into CAD heritability being able to disentangle the traditional dyad of genetic and environmental factors and investigate the within-pair epigenetic drift.

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Coronary angioplasty in identical twins

Cited by 3 publications

References 7 publications

Vasospastic Angina in Identical Twins

Vasospastic Angina in Identical Twins

Monozygotic Twins with Identical Cardiac Conditions

Concomitant Coronary Artery Disease in Identical Twins: Case Report and Systematic Literature Review

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