Coronarin D induces human oral cancer cell apoptosis though upregulate JNK1/2 signaling pathway

Abstract

The incidence of oral cancer is increasing all over the world, with rates particularly high in Southeast Asian countries, such as Taiwan. Coronarin D (CD) has been confirmed to have anti-inflammatory, anti-bacterial effects, and anti-apoptotic effects in human hepatocellular carcinoma and nasopharyngeal carcinoma. The purpose of this study is to explore whether CD has a suppression effect on oral cancer cells and the mechanisms involved. The results of our study revealed the significantly decreased cancer cell viability and increased activation of apoptosis via increased loss of mitochondrial membrane potential, increased death receptors, leading to the activation of caspase-8, -9, -3. Moreover, the rate of apoptosis of cells treated with CD plus JNK inhibitors was decreased compared to CD-treated cells. This is the first study to demonstrate that CD induces apoptosis in human oral cancer cells and can be expected to be a promising anticancer agent for oral cancer treatment. K E Y W O R D S apoptosis, caspase, Coronarin D, MAPK, oral cancer

Coronarin D Induces Apoptotic Cell Death and Cell Cycle Arrest in Human Glioblastoma Cell Line

“…Further, Coronarin D exhibits antiproliferative, pro-apoptotic, anti-invasive, antiangiogenic, antiosteoclast, and anti-inflammatory activity by suppressing NF-κB and the gene products regulated by this pathway of osteoclastogenesis [24]. Recently, Coronarin D has been described as inducing apoptosis in human hepatocellular carcinoma (HCC) [25] and in human oral cancer (OSCC) [26] through the c-Jun N-terminal kinases (JNK) pathway while it has induced reactive oxygen species-mediated cell death in human nasopharyngeal cancer cells (NPC) through inhibition of p38 mitogen-activated protein kinase (MAPK) and activation of JNK [27].…”

The Ginger Prophecy; A Review of the Underexplored Genus, Hedychium against Cancer

“…According to previous and latest reports, coronarin E is shown to have positive cytotoxic effect on HL-60 (leukemic), THP-1 (leukemic), A-375 (melanoma) and A549 (lung) cancer cell lines [106] . Similarly, coronarin D was found to have induced apoptosis and G2/M cell cycle arrest in human oral cancer cell lines SAS and SCC-9 [120] .…”

Advances in Small Molecular Agents against Oral Cancer

“…It can also effectively inhibit tumour formation in vivo in xenotransplantation models of oral cancer. Coronarin D (45) can significantly reduce cancer cell viability by increasing the loss of mitochondrial membrane potential and the expression of death receptors, resulting in the activation of caspase-3/8/9 [79]. It also induces the apoptosis of human SCC-9 and SAS cells by causing G2/M phase arrest, decreasing the activation of ERK1/2, p-38, and AKT, and increasing the activation of JNK1/2.…”