Coronal Suture Response to Distraction Osteogenesis in Rabbits With Delayed-Onset Craniosynostosis

Losken, H. Wolfgang; Mooney, P. Mark; Zoldos, Josef; Tschakaloff, Alexander; Burrows, Annie M.; Smith, Timothy D.; Cano, G.G.; Arnott, Richard; Sherwood, C.P.; Dechant, Jason; Cooper, Gregory M.; Kapucu, M. Ruşen; Siegel, Michael I.

doi:10.1097/00001665-199901000-00007

Cited by 20 publications

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“…1) at 10 days of age and the quantitative assessment of coronal suture growth from serial radiographs (Mooney et al, 1994b(Mooney et al, , 1996aBurrows et al, 1995;Losken et al, 1998Losken et al, , 1999. Cephalographs of the rabbits were taken at 10 and 25 days of age, and rabbits in which coronal suture marker separation fell below the 95% confidence interval of the mean for unaffected rabbits were classified as having delayed-onset synostosis.…”

Section: Surgerymentioning

confidence: 99%

“…Rabbits with delayed-onset synostosis average about 70 -75% of normal coronal suture growth, and usually fuse by 42 days of age ( Fig. 1) (Mooney et al, 1994a;Burrows et al, 1995;Losken et al, 1998Losken et al, , 1999.…”

Section: Surgerymentioning

confidence: 99%

“…Serial lateral and dorsoventral head radiographs were taken with the rabbits tranquilized with an IM injection (0.40 ml/kg) of a solution of 9l% Ketaset (ketamine hydrochloride, 100 mg/ ml; Aveco Co. Inc., Fort Dodge, IA) and 9% Rompun (xy- lazine, 20 mg/ml; Mobay Corp., Shawnee, KS). The heads were immobilized in a specially designed cephalostat, and a Philips Oralix 70 dental x-ray unit (Shelton, CT) was used at an exposure of 50kV, 7mA, with a .17-.50-sec exposure time, and a tube-to-cassette distance held constant at 152 cm (Mooney et al, 1994b;Burrows et al, 1995;Losken et al, 1998Losken et al, , 1999. The radiographs were viewed on a light box, and the amalgam markers at the coronal suture were identified and traced on acetate tracing paper (Figs.…”

Section: Data Collectionmentioning

confidence: 99%

“…In particular, a number of clinical (Reddy et al, 1990;Hoffman and Reddy, 1991;Cohen et al, 1993;Cohen and MacLean, 2000) and animal (Mooney et al, 1994a(Mooney et al, , 1996a(Mooney et al, , 2002bBurrows et al, 1995;Losken et al, 1998Losken et al, , 1999) studies have identified and described a subset of craniosynostotic individuals with familial, nonsyndromic, delayed-onset (i.e., postgestational) craniosynostosis. Although the pathogenesis of delayed-onset or progressive synostosis is not known, it has been suggested that this condition may be a variable phenotypic expression of a familial craniosynostotic condition, and may represent part of a synostotic continuum (Reddy et al, 1990;Hoffman and Reddy, 1991;Cohen et al, 1993;Mooney et al, 1994aMooney et al, , 1996aMooney et al, , 2002Losken et al, 1998Losken et al, , 1999. While the suture is not completely synostosed in craniosynostotic individuals, dense collagen bundles and small bony bridges have been observed crossing the suture (Mooney et al, 1996a,b;Losken et al, 1999).…”

mentioning

confidence: 99%

“…Although the pathogenesis of delayed-onset or progressive synostosis is not known, it has been suggested that this condition may be a variable phenotypic expression of a familial craniosynostotic condition, and may represent part of a synostotic continuum (Reddy et al, 1990;Hoffman and Reddy, 1991;Cohen et al, 1993;Mooney et al, 1994aMooney et al, , 1996aMooney et al, , 2002Losken et al, 1998Losken et al, , 1999. While the suture is not completely synostosed in craniosynostotic individuals, dense collagen bundles and small bony bridges have been observed crossing the suture (Mooney et al, 1996a,b;Losken et al, 1999). These structures could effectively immobilize the suture, and result in growth restrictions and altered brain growth vectors.…”

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Rescue of coronal suture fusion using transforming growth factor‐beta 3 (Tgf‐β3) in rabbits with delayed‐onset craniosynostosis

et al. 2003

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Craniosynostosis results in cranial deformities and increased intracranial pressure, which pose extensive and recurrent surgical management problems. Developmental studies in rodents have shown that low levels of transforming growth factor-␤3 (Tgf-␤3) are associated with normal fusion of the interfrontal (IF) suture, and that Tgf-␤3 prevents IF suture fusion in a dose-dependent fashion. The present study was designed to test the hypothesis that Tgf-␤3 can also prevent or "rescue" fusing sutures in a rabbit model with familial craniosynostosis. One hundred coronal sutures from 50 rabbits with delayed-onset, coronal suture synostosis were examined in the present study. The rabbits were divided into five groups of 10 rabbits each: 1) sham controls, 2) bovine serum albumin (BSA, 500 ng) low-dose protein controls, 3) low-dose Tgf-␤3 (500 ng), 4) high-dose BSA (1,000 ng) controls, and 5) high-dose Tgf-␤3 (1,000 ng). At 10 days of age, radiopaque amalgam markers were implanted in all of the rabbits on either side of the coronal suture to monitor sutural growth. At 25 days of age, the BSA or Tgf-␤3 was combined with a slow-absorbing collagen vehicle and injected subperiosteally above the coronal suture. Radiographic results revealed that high-dose Tgf-␤3 rabbits had significantly greater (P Ͻ 0.05) coronal suture marker separation than the other groups. Histomorphometric analysis revealed that high-dose Tgf-␤3 rabbits also had patent coronal sutures and significantly (P Ͻ 0.01) greater sutural widths and areas than the other groups. The results suggest that there is a dose-dependent effect of TGF-␤3 on suture morphology and area in these rabbits, and that the manipulation of such growth factors may have clinical applications in the treatment of craniosynostosis. Anat Rec Part A 274A: 962-971, 2003.

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Section: Surgerymentioning

confidence: 99%

Section: Surgerymentioning

confidence: 99%

Section: Data Collectionmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Rescue of coronal suture fusion using transforming growth factor‐beta 3 (Tgf‐β3) in rabbits with delayed‐onset craniosynostosis

et al. 2003

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The Effect of New Technologies on Plastic Surgery

Mustoe¹

1999

Arch Surg

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A Brief Introduction to the Biomechanics of Craniofacial Sutures

Marghoub

Hejazi

Cross

et al. 2021

The Sutures of the Skull

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The biomechanical studies on the craniofacial sutures can be classified to three groups, to understand: (1) the inherent mechanical properties of the sutures; (2) role and function of the sutures (using in vivo and in silico techniques) and (3) how sutures respond to mechanical loads (using in vitro or in vivo experiments). The aim of this chapter was to provide a short overview of the biomechanics of the sutures under the aforementioned categories. This chapter can be consider as an introduction to the biomechanics of the sutures and readers are encouraged to read throught the papers reviewed here.

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Coronal Suture Response to Distraction Osteogenesis in Rabbits With Delayed-Onset Craniosynostosis

Cited by 20 publications

References 0 publications

Rescue of coronal suture fusion using transforming growth factor‐beta 3 (Tgf‐β3) in rabbits with delayed‐onset craniosynostosis

Rescue of coronal suture fusion using transforming growth factor‐beta 3 (Tgf‐β3) in rabbits with delayed‐onset craniosynostosis

The Effect of New Technologies on Plastic Surgery

A Brief Introduction to the Biomechanics of Craniofacial Sutures

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